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Artículo
Research facilities and highlights at the Centro Nacional de Aceleradores (CNA)
(Springer, 2021)
The Centro Nacional de Aceleradores is a user-oriented accelerator facility in Seville, Spain. Its main facilities are a 3 MV tandem accelerator, an 18 MeV proton Cyclotron, a tandetron used for AMS, a compact accelerator ...
Artículo
CSPα, a molecular co-chaperone essential for short and long-term synaptic maintenance
(Frontiers Media S.A., 2017-02-10)
Cysteine string protein a (CSPα) is a vesicle protein located in the presynaptic terminal of most synapses. CSPα is an essential molecular co-chaperone that facilitates the correct folding of proteins and the assembly of ...
Artículo
Editorial: Molecular Components of Store-Operated Calcium Entry in Health and Disease
(Frontiers Media, 2021-10-05)
Store-Operated Calcium Entry (SOCE) is a ubiquitous Ca2+ influx mechanism first described in 1986 (Putney, 1986). This conserved mechanism results from the interaction between the tetraspanning ORAI1 channel located in ...
Artículo
Spike protein of SARS-CoV-2 Omicron variant An in-silico study evaluating spike interactions and immune evasion
(Frontiers Media, 2022-11-29)
Background: The fundamentals of the infectivity and immune evasion of the SARS-CoV-2 Omicron variant are not yet fully understood. Here, we carried out an in-silico study analyzing the spike protein, the protein electrostatic ...
Artículo
Microglia mitochondrial complex I deficiency during development induces glial dysfunction and early lethality
(Nature, 2024-07-24)
Primary mitochondrial diseases (PMDs) are associated with pediatric neurological disorders and are traditionally related to oxidative phosphorylation system (OXPHOS) defects in neurons. Interestingly, both PMD mouse models ...
Artículo
Presenilin/γ-Secretase Regulates Neurexin Processing at Synapses
(Public Library of Science, 2011-04-29)
Neurexins are a large family of neuronal plasma membrane proteins, which function as trans-synaptic receptors during synaptic differentiation. The binding of presynaptic neurexins to postsynaptic partners, such as neuroligins, ...
Artículo
Carotid body function in tyrosine hydroxylase conditional Olfr78 knockout mice
(Oxford University Press, 2024-02-22)
The Olfr78 gene encodes a G-protein-coupled olfactory receptor that is expressed in several ectopic sites. Olfr78 is one of the most abundant mRNA species in carotid body (CB) glomus cells. These cells are the prototypical ...