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PhD Thesis
Estudio neurofisiológico del bulbo caudal de la rata papel en la quimiosensibilidad central
(2003)
En el siglo XIX, el fisiólogo francés Claude Bernard estableció una de las hipótesis de mayor relevancia en el área de la Fisiología y que ha perdurado hasta la fecha: "La condición para la vida libre viene determinada por ...
Patent
Evaluación en tiempo real de dosis de neutrones en pacientes en tratamiento con radioterapia y detector para llevar a cabo el procedimiento
(Oficina Española de Patentes y Marcas , 2015-06-11)
Evaluación en tiempo real de dosis de neutrones en pacientes en tratamiento con radioterapia y detector para llevar a cabo el procedimiento.Procedimiento y detector para calcular las dosis equivalentes de neutrones en ...
Article
Combined treatment of graft versus host disease using donor regulatory T cells and ruxolitinib
(Nature Publishing Group, 2022)
Donor derived regulatory T lymphocytes and the JAK1/2 kinase inhibitor ruxolitinib are currently being evaluated as therapeutic options in the treatment of chronic graft versus host disease (cGvHD). In this work, we ...
Article
Protection and repair of the nigrostriatal pathway with stem-cell-derived carotid body glomus cell transplants in chronic MPTP Parkinsonian model
(MDPI, 2023-03-14)
Antiparkinsonian carotid body (CB) cell therapy has been proven to be effective in rodent and nonhuman primate models of Parkinson’s disease (PD), exerting trophic protection and restoration of the dopaminergic nigrostriatal ...
Article
Mitochondria and T2D: Role of Autophagy, ER Stress, and Inflammasome
(Cell Press, 2020)
Type 2 diabetes (T2D) is one of the main current threats to human health. Both T2D and its numerous clinical complications are related to mitochondrial dysfunction and oxidative stress. Over the past decade, great progress ...
Article
Cholinergic deficits selectively boost cortical intratelencephalic control of striatum in male Huntington's disease model mice
(NATURE PUBLISHING GROUP, 2023)
Huntington’s disease (HD) is a progressive, neurodegenerative disease caused by a CAG triplet expansion in huntingtin. Although corticostriatal dysfunction has long been implicated in HD, the determinants and pathway ...
Patent
Método para el diagnóstico de la enfermedad de parkinson en estadios tempranos
(Oficina Española de Patentes y Marcas , 2014-07-30)
Método para el diagnóstico de la enfermedad de Parkinson en estadios tempranos.La presente invención se relaciona con un método in vitro para el diagnóstico de la enfermedad de Parkinson que comprende la cuantificación en ...
Article
Two for the Price of One: A Neuroprotective Chaperone Kit within NAD Synthase Protein NMNAT2
(Public Library of Science, 2016-07-25)
One of the most fascinating properties of the brain is the ability to function smoothly across decades of a lifespan. Neurons are nondividing mature cells specialized in fast electrical and chemical communication at ...
PhD Thesis
Fisiología del Sistema Motor del párpado
(1999-11-17)
Article
Proteomic characterization of spinal cord synaptoneurosomes from Tg-SOD1/G93A mice supports a role for MNK1 and local translation in the early stages of amyotrophic lateral sclerosis
(Elsevier, 2022-11)
The isolation of synaptoneurosomes (SNs) represents a useful means to study synaptic events. However, the size and density of synapses varies in different regions of the central nervous system (CNS), and this also depends ...