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Tesis Doctoral
Caracterización del papel de las poblaciones inflamatorias en el infarto revascularizado y sus implicaciones en el remodelado adverso
(2023-07-13)
La revascularización temprana después del infarto permite reestablecer el flujo sanguíneo a la zona infartada del corazón limitando el daño producido durante la isquemia. Sin embargo, se sabe que la revascularización ...
Artículo
Orai2 Modulates Store-Operated Ca2+ Entry and Cell Cycle Progression in Breast Cancer Cells
(MDPI, 2021-12-27)
Breast cancer is a heterogeneous disease from the histological and molecular expression point of view, and this heterogeneity determines cancer aggressiveness. Store-operated Ca2+ entry (SOCE), a major mechanism for Ca2+ ...
Artículo
Store-operated calcium entry in breast cancer cells is insensitive to Orai1 and STIM1 N-linked glycosylation
(MDPI, 2022-12-29)
N-linked glycosylation is a post-translational modification that affects protein function, structure, and interaction with other proteins. The store-operated Ca2+ entry (SOCE) core proteins, Orai1 and STIM1, exhibit ...
Artículo
Podoplanin Gene Disruption in Mice Promotes in vivo Neural Progenitor Cells Proliferation, Selectively Impairs Dentate Gyrus Synaptic Depression and Induces Anxiety-Like Behaviors.
(2020-01-15)
Podoplanin (Pdpn), a brain-tumor-related glycoprotein identified in humans and animals, is endogenously expressed in several organs critical for life support such as kidney, lung, heart and brain. In the brain, Pdpn has ...
Tesis Doctoral
Artículo
Editorial: Involvements of TRP channels, oxidative stress and apoptosis in neurodegenerative diseases
(Fontiers Media SA, 2021)
The oxygen free radicals generated during metabolism can cause cumulative oxidative damage to nucleic acids, lipids, and protein, resulting in structural degeneration, apoptosis, functional decline, and age-related ...
Tesis Doctoral
Remodelado de la entrada de calcio en la angiogénesis: papel de las proteínas ORAI1 Y SARAF
(2022-07-04)
La angiogénesis se define como el proceso llevado a cabo por las células endoteliales (CE) por el cual se forman nuevos vasos sanguíneos a partir de otros preexistentes. Su regulación es precisa y está controlada por ...
Artículo
Urocortin Role in Ischemia Cardioprotection and the Adverse Cardiac Remodeling
(MDPI, 2021-11-09)
Despite the considerable progress in strategies of myocardial protection, ischemic heart diseases (IHD) and consequent heart failure (HF) remain the main cause of mortality worldwide. Several procedures are used routinely ...
Tesis Doctoral
Remodelado ventricular adverso tras reperfusión aguda. Efecto cardioprotector de la Urocortina-2
(2021-07-02)
Las enfermedades cardiovasculares son la principal causa de muerte en el mundo desarrollado, siendo tres de ellas las más prevalentes para ambos sexos; cardiopatía isquémica (13 % de la mortalidad mundial), ictus (12 %) e ...
Artículo
Orai1 and TRPC1 Proteins Co-localize with CaV1.2 Channels to Form a Signal Complex in Vascular Smooth Muscle Cells
(American Society for Biochemistry and Molecular Biology, 2016)
Voltage-dependent CaV1.2 L-type Ca2 channels (LTCC) are the main route for calcium entry in vascular smooth muscle cells (VSMC). Several studies have also determined the relevant role of store-operated Ca2 channels ...