Artículo
Editorial: Involvements of TRP channels, oxidative stress and apoptosis in neurodegenerative diseases
Autor/es | Braidy, Nady
Smani Hajami, Tarik ![]() ![]() ![]() ![]() ![]() ![]() ![]() Naziroglu, Mustafa |
Departamento | Universidad de Sevilla. Departamento de Fisiología Médica y Biofísica |
Fecha de publicación | 2021 |
Fecha de depósito | 2022-10-17 |
Publicado en |
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Resumen | The oxygen free radicals generated during metabolism can cause cumulative oxidative damage to
nucleic acids, lipids, and protein, resulting in structural degeneration, apoptosis, functional decline,
and age-related ... The oxygen free radicals generated during metabolism can cause cumulative oxidative damage to nucleic acids, lipids, and protein, resulting in structural degeneration, apoptosis, functional decline, and age-related degenerative diseases involving the cardiovascular, endocrine, neurologic, immune, respiratory, gastrointestinal, and reproductive systems. The transient receptor potential (TRP) protein superfamily is composed of several cation-permeable channels that are widely distributed in mammalian cells. TRP channels can be divided into six subfamilies that are dependent on their sequence identity. These channels play a crucial role in the regulation of oxidative stress and should be considered as likely targets for the treatment of age-related neurodegenerative diseases associated with chronic oxidative stress, decreases in metabolic regulation, and cell viability. |
Cita | Braidy, N., Smani Hajami, T. y Naziroglu, M. (2021). Editorial: Involvements of TRP channels, oxidative stress and apoptosis in neurodegenerative diseases. Frontiers in Physiology, 12. https://doi.org/10.3389/fphys.2021.649230. |
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