Now showing items 1-5 of 5
Rotenone selectively occludes sensitivity to hypoxia in rat carotid body glomus cells
(Wiley-Blackwell Publishing Ltd., 2003)
Carotid body glomus cells release transmitters in response to hypoxia due to the increase of excitability resulting from inhibition of O2 -regulated K+ channels. However, the mechanisms involved in the detection of changes ...
Physiological Plasticity of Neural-Crest-Derived Stem Cells in the Adult Mammalian Carotid Body
(Cell Press, 2017)
Adult stem cell plasticity, or the ability of somatic stem cells to cross boundaries and differentiate into unrelated cell types, has been amatter of debate in the last decade. Neural-crest-derived stem cells (NCSCs) ...
Gene expression profiling supports the neural crest origin of adult rodent carotid body stem cells and identifies CD10 as a marker for mesectoderm-committed progenitors
Neural stem cells (NSCs) are promising tools for understanding nervous system plasticity and repair, but their use is hampered by the lack of markers suitable for their prospective isolation and characterization. The carotid ...
Neurotransmitter Modulation of Carotid Body Germinal Niche
(MDPI AG, 2020-11-03)
The carotid body (CB), a neural-crest-derived organ and the main arterial chemoreceptor in mammals, is composed of clusters of cells called glomeruli. Each glomerulus contains neuron-like, O2-sensing glomus cells, which ...
The carotid body: a physiologically relevant germinal niche in the adult peripheral nervous system
Oxygen constitutes a vital element for the survival of every single cell in multicellular aerobic organisms like mammals. A complex homeostatic oxygen-sensing system has evolved in these organisms, including detectors and ...