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Artículo
Two for the Price of One: A Neuroprotective Chaperone Kit within NAD Synthase Protein NMNAT2
(Public Library of Science, 2016-07-25)
One of the most fascinating properties of the brain is the ability to function smoothly across decades of a lifespan. Neurons are nondividing mature cells specialized in fast electrical and chemical communication at ...
Artículo
Effect of hypoxia on lung gene expression and proteomic profile: insights into the pulmonary surfactant response
(Elsevier, 2014)
Exposure of lung to hypoxia has been previously reported to be associated with significant alterations in the protein content of bronchoalveolar lavage (BAL) and lung tissue. In the present work we have used a proteomic ...
Artículo
Resistance of subventricular neural stem cells to chronic hypoxemia despite structural disorganization of the germinal center and impairment of neuronal and oligodendrocyte survival
(Dove Medical Press Ltd., 2015)
Chronic hypoxemia, as evidenced in de-acclimatized high-altitude residents or in patients with chronic obstructive respiratory disorders, is a common medical condition that can produce serious neurological alterations. ...
Artículo
Simvastatin and metformin inhibit cell growth in hepatitis C virus infected cells via mTOR increasing PTEN and autophagy
(2018-01-31)
Hepatitis C virus (HCV) infection has been related to increased risk of development of hepa tocellular carcinoma (HCC) while metformin (M) and statins treatment seemed to protect against HCC development. In this work, we ...
Artículo
Altered Intracellular Ca2+ Homeostasis in Nerve Terminals of Severe Spinal Muscular Atrophy Mice
(SOC NEUROSCIENCE, 2010)
Low levels of survival motor neuron (SMN) protein result in spinal muscular atrophy (SMA), a severe genetic disease characterized by motor impairment and premature lethality. Although SMN is a ubiquitous protein, motor ...
Artículo
Morphological and functional remodelling of the neuromuscular junction by skeletal muscle PGC-1 alpha
(NATURE PUBLISHING GROUP, 2014-04-04)
The neuromuscular junction (NMJ) exhibits high morphological and functional plasticity. In the mature muscle, the relative levels of physical activity are the major determinants of NMJ function. Classically, motor ...
Artículo
La plasticidad sináptica mediada por endocannabinoides y «trastornos por consumo de drogas»
(Elsevier, 2019)
Las drogas impactan en los circuitos de recompensa cerebrales y originan depen dencia y adicción, lo que se define actualmente como trastornos por consumo de drogas. Los mecanismos de plasticidad sináptica en dichos ...
Artículo
HIF-2a is essential for carotid body development and function
(eLife Sciences Publications, 2018-04-19)
Mammalian adaptation to oxygen flux occurs at many levels, from shifts in cellular metabolism to physiological adaptations facilitated by the sympathetic nervous system and carotid body (CB). Interactions between differing ...
Artículo
Editorial: Molecular nanomachines of the presynaptic terminal
(Frontiers Research Foundation, 2016)
Artículo
Selective accumulation of biotin in arterial chemoreceptors: requirement for carotid body exocytotic dopamine secretion
(2016-12)
Biotin is a water-soluble vitamin required for the function of carboxylases as well asfor the regulation of gene expression. Here, we report that biotin accumulates in unusually largeamounts in cells of arterial chemoreceptors, ...