Tumor Immune Microenvironment in Lymphoma: Focus on Epigenetics
|Author/s||García Domínguez, Daniel
Hontecillas Prieto, Lourdes
Palazón Carrión, Natalia
Jiménez Cortegana, Carlos
Sánchez Margalet, Víctor
Cruz Merino, Luis de la
|Department||Universidad de Sevilla. Departamento de Bioquímica Médica y Biología Molecular e Inmunología
Universidad de Sevilla. Departamento de Medicina
|Abstract||Lymphoma is a neoplasm arising from B or T lymphocytes or natural killer cells characterized by clonal lymphoproliferation. This tumor comprises a diverse and heterogeneous group of malignancies with distinct clinical, ...
Lymphoma is a neoplasm arising from B or T lymphocytes or natural killer cells characterized by clonal lymphoproliferation. This tumor comprises a diverse and heterogeneous group of malignancies with distinct clinical, histopathological, and molecular characteristics. Despite advances in lymphoma treatment, clinical outcomes of patients with relapsed or refractory disease remain poor. Thus, a deeper understanding of molecular pathogenesis and tumor progression of lymphoma is required. Epigenetic alterations contribute to cancer initiation, progression, and drug resistance. In fact, over the past decade, dysregulation of epigenetic mechanisms has been identified in lymphomas, and the knowledge of the epigenetic aberrations has led to the emergence of the promising epigenetic therapy field in lymphoma tumors. However, epigenetic aberrations in lymphoma not only have been found in tumor cells, but also in cells from the tumor microenvironment, such as immune cells. Whereas the epigenetic dysregulation in lymphoma cells is being intensively investigated, there are limited studies regarding the epigenetic mechanisms that affect the functions of immune cells from the tumor microenvironment in lymphoma. Therefore, this review tries to provide a general overview of epigenetic alterations that affect both lymphoma cells and infiltrating immune cells within the tumor, as well as the epigenetic cross-talk between them.
|Citation||García Domínguez, D., Hontecillas Prieto, L., Palazón Carrión, N., Jiménez Cortegana, C., Sánchez Margalet, V. y Cruz Merino, L.d.l. (2022). Tumor Immune Microenvironment in Lymphoma: Focus on Epigenetics. Cancers, 14 (6), 1-30. https://doi.org/10.3390/cancers14061469.|