Circulating immune biomarkers in peripheral blood correlate with clinical outcomes in advanced breast cancer
|Author/s||Palazón Carrión, Natalia
Jiménez Cortegana, Carlos
Sánchez León, María Luisa
Nieto García, María Adoración
Sánchez Margalet, Víctor
Cruz Merino, Luis de la
|Department||Universidad de Sevilla. Departamento de Bioquímica Médica y Biología Molecular e Inmunología
Universidad de Sevilla. Departamento de Medicina Preventiva y Salud Pública
Universidad de Sevilla. Departamento de Medicina
|Abstract||Identification of the different elements intervening at the tumor microenvironment seems key to explain clinical evolution in several tumor types. In this study, a set of immune biomarkers (myeloid derived suppressor cells, ...
Identification of the different elements intervening at the tumor microenvironment seems key to explain clinical evolution in several tumor types. In this study, a set of immune biomarkers (myeloid derived suppressor cells, regulatory T cells, and OX40 + and PD-1 + T lymphocytes counts) in peripheral blood of patients diagnosed with advanced breast cancer were analyzed along of first line antineoplastic therapy. Subsequently, a comparison between groups with clinical benefit versus progression of disease and with a healthy women cohort was executed. Results reflected that patients showed higher basal levels of myeloid derived suppressor cells (35.43, IR = 180.73 vs 17.53, IR = 16.96 cells/μl; p = 0.001) and regulatory T cells (32.05, IR = 29.84 vs 22.61, IR = 13.57 cells/μl; p = 0.001) in comparison with healthy women. Furthermore, an increase in the number of activated T lymphocytes (expressing OX40), a decrease of immune inhibitory cells (MDSCs and Tregs) and inhibited T lymphocytes (expressing PD-1) were observed along the treatment in patients with clinical benefit (p ≤ 0.001). The opposite trend was observed in the case of disease progression. These findings suggest that some critical immune elements can be easily detected and measured in peripheral blood, which open a new opportunity for translational research, as they seem to be correlated with clinical evolution, at least in ABC.
|Citation||Palazón Carrión, N., Jiménez Cortegana, C., Sánchez León, M.L., Nieto García, M.A., Sánchez Margalet, V. y Cruz Merino, L.d.l. (2021). Circulating immune biomarkers in peripheral blood correlate with clinical outcomes in advanced breast cancer. Scientific Reports, 11 (1), 17639. https://doi.org/10.1038/s41598-021-93838-w.|