Artículo
Role of Leptin as a Link between Asthma and Obesity: A Systematic Review and Meta-Analysis
Autor/es | Sánchez-Ortega, Helena
Jiménez Cortegana, Carlos Novalbos-Ruiz, José P. Gómez-Bastero, Ana Soto-Campos, José G. Sánchez Margalet, Víctor |
Departamento | Universidad de Sevilla. Departamento de Bioquímica Médica y Biología Molecular e Inmunología |
Fecha de publicación | 2022-12-29 |
Fecha de depósito | 2023-05-30 |
Publicado en |
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Resumen | Asthma and obesity are considered as highly prevalent diseases with a great impact on
public health. Obesity has been demonstrated to be an aggravating factor in the pathogenesis of
asthma. Adipose tissue secretes ... Asthma and obesity are considered as highly prevalent diseases with a great impact on public health. Obesity has been demonstrated to be an aggravating factor in the pathogenesis of asthma. Adipose tissue secretes proinflammatory cytokines and mediators, including leptin, which may promote the development and severity of asthma in obese patients. This study is a systematic review and a meta-analysis based on the relationship between leptin and asthma during obesity. MEDLINE, Cochrane, EMBASE and CINAHL databases were used. Data heterogeneity was analyzed using Cochran’s Q and treatment effect with the DerSimonian and Laird method. Random effect analyses were carried out to test data sensitivity. Asymmetry was estimated using Begg’s and Egger’s tests. All studies showed significant differences in leptin levels. The effect of the measures (p < 0.001), data sensitivity (p < 0.05) and data asymmetry were statistically significant, as well as tBegg’s test (p = 0.010) and Egge’s test (p < 0.001). Despite the existing limiting factors, the results of this study support the relevant role of leptin in the pathophysiology of asthma in obese subjects. Nevertheless, further studies are needed to obtain better insight in the relationship between leptin and asthma in obesity |
Agencias financiadoras | Plan Andaluz de Investigación. Junta de Andalucía. España |
Identificador del proyecto | CTS-151 |
Cita | Sánchez-Ortega, H., Jiménez Cortegana, C., Novalbos-Ruiz, J.P., Gómez-Bastero, A., Soto-Campos, J.G. y Sánchez Margalet, V. (2022). Role of Leptin as a Link between Asthma and Obesity: A Systematic Review and Meta-Analysis. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 24 (1), 546. https://doi.org/10.3390/ijms24010546. |
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