dc.creator | Sánchez-Ortega, Helena | es |
dc.creator | Jiménez Cortegana, Carlos | es |
dc.creator | Novalbos-Ruiz, José P. | es |
dc.creator | Gómez-Bastero, Ana | es |
dc.creator | Soto-Campos, José G. | es |
dc.creator | Sánchez Margalet, Víctor | es |
dc.date.accessioned | 2023-05-30T13:22:41Z | |
dc.date.available | 2023-05-30T13:22:41Z | |
dc.date.issued | 2022-12-29 | |
dc.identifier.citation | Sánchez-Ortega, H., Jiménez Cortegana, C., Novalbos-Ruiz, J.P., Gómez-Bastero, A., Soto-Campos, J.G. y Sánchez Margalet, V. (2022). Role of Leptin as a Link between Asthma and Obesity: A Systematic Review and Meta-Analysis. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 24 (1), 546. https://doi.org/10.3390/ijms24010546. | |
dc.identifier.issn | 1422-0067 | es |
dc.identifier.uri | https://hdl.handle.net/11441/146784 | |
dc.description.abstract | Asthma and obesity are considered as highly prevalent diseases with a great impact on
public health. Obesity has been demonstrated to be an aggravating factor in the pathogenesis of
asthma. Adipose tissue secretes proinflammatory cytokines and mediators, including leptin, which
may promote the development and severity of asthma in obese patients. This study is a systematic
review and a meta-analysis based on the relationship between leptin and asthma during obesity.
MEDLINE, Cochrane, EMBASE and CINAHL databases were used. Data heterogeneity was analyzed
using Cochran’s Q and treatment effect with the DerSimonian and Laird method. Random effect
analyses were carried out to test data sensitivity. Asymmetry was estimated using Begg’s and Egger’s
tests. All studies showed significant differences in leptin levels. The effect of the measures (p < 0.001),
data sensitivity (p < 0.05) and data asymmetry were statistically significant, as well as tBegg’s test
(p = 0.010) and Egge’s test (p < 0.001). Despite the existing limiting factors, the results of this study
support the relevant role of leptin in the pathophysiology of asthma in obese subjects. Nevertheless,
further studies are needed to obtain better insight in the relationship between leptin and asthma
in obesity | es |
dc.format | application/pdf | es |
dc.format.extent | 13 p. | es |
dc.language.iso | eng | es |
dc.publisher | MDPI | es |
dc.relation.ispartof | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 24 (1), 546. | |
dc.rights | Atribución 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.subject | Asthma | es |
dc.subject | Obesity | es |
dc.subject | Inflammation | es |
dc.subject | Adipokines | es |
dc.subject | Leptin | es |
dc.subject | Immune system | es |
dc.title | Role of Leptin as a Link between Asthma and Obesity: A Systematic Review and Meta-Analysis | es |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Bioquímica Médica y Biología Molecular e Inmunología | es |
dc.relation.projectID | CTS-151 | es |
dc.relation.publisherversion | https://www.mdpi.com/1422-0067/24/1/546 | es |
dc.identifier.doi | 10.3390/ijms24010546 | es |
dc.journaltitle | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | es |
dc.publication.volumen | 24 | es |
dc.publication.issue | 1 | es |
dc.publication.initialPage | 546 | es |
dc.contributor.funder | Plan Andaluz de Investigación. Junta de Andalucía. España | es |