dc.creator | Jiménez Cortegana, Carlos | es |
dc.creator | Salamanca, Elena | es |
dc.creator | Palazón Carrión, Natalia | es |
dc.creator | Sánchez Jiménez, Flora | es |
dc.creator | Pérez Pérez, Antonio | es |
dc.creator | Vilariño García, Teresa | es |
dc.creator | Gutiérrez Gutiérrez, Belén | es |
dc.creator | Garnacho Montero, José | es |
dc.creator | Cruz Merino, Luis de la | es |
dc.creator | Rodríguez-Baño, Jesús | es |
dc.creator | Sánchez Margalet, Víctor | es |
dc.date.accessioned | 2024-03-01T14:34:20Z | |
dc.date.available | 2024-03-01T14:34:20Z | |
dc.date.issued | 2023 | |
dc.identifier.citation | Jiménez Cortegana, C., Salamanca, E., Palazón Carrión, N., Sánchez Jiménez, F., Pérez Pérez, A., Vilariño García, T.,...,Sánchez Margalet, V. (2023). Circulating myeloid-derived suppressor cells may be a useful biomarker in the follow-up of unvaccinated COVID-19 patients after hospitalization. Frontiers in Immunology, 14, 1266659. https://doi.org/10.3389/fimmu.2023.1266659. | |
dc.identifier.issn | 1664-3224 | es |
dc.identifier.uri | https://hdl.handle.net/11441/155757 | |
dc.description.abstract | SARS-CoV-2 infection is the cause of the disease named COVID-19, a major
public health challenge worldwide. Differences in the severity, complications and
outcomes of the COVID-19 are intriguing and, patients with similar baseline
clinical conditions may have very different evolution. Myeloid-derived suppressor
cells (MDSCs) have been previously found to be recruited by the SARS-CoV-2
infection and may be a marker of clinical evolution in these patients. We have
studied 90 consecutive patients admitted in the hospital before the vaccination
program started in the general population, to measure MDSCs and lymphocyte
subpopulations at admission and one week after to assess the possible
association with unfavorable outcomes (dead or Intensive Care Unit
admission). We analyzed MDSCs and lymphocyte subpopulations by flow
cytometry. In the 72 patients discharged from the hospital, there were
significant decreases in the monocytic and total MDSC populations measured
in peripheral blood after one week but, most importantly, the number of MDSCs (total and both monocytic and granulocytic subsets) were much higher in the 18
patients with unfavorable outcome. In conclusion, the number of circulating
MDSCs may be a good marker of evolution in the follow-up of unvaccinated
patients admitted in the hospital with the diagnosis of COVID-19. | es |
dc.format | application/pdf | es |
dc.format.extent | 9 p. | es |
dc.language.iso | eng | es |
dc.publisher | Frontiers Media S.A. | es |
dc.relation.ispartof | Frontiers in Immunology, 14, 1266659. | |
dc.rights | Atribución 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.subject | SARS-CoV-2 | es |
dc.subject | COVID-19 | es |
dc.subject | MDSCs | es |
dc.subject | T lymphocytes | es |
dc.subject | Biomarker | es |
dc.title | Circulating myeloid-derived suppressor cells may be a useful biomarker in the follow-up of unvaccinated COVID-19 patients after hospitalization | es |
dc.type | info:eu-repo/semantics/article | es |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Medicina | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Bioquímica Médica y Biología Molecular e Inmunología | es |
dc.relation.publisherversion | https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2023.1266659/full | es |
dc.identifier.doi | 10.3389/fimmu.2023.1266659 | es |
dc.journaltitle | Frontiers in Immunology | es |
dc.publication.volumen | 14 | es |
dc.publication.initialPage | 1266659 | es |
dc.description.awardwinning | Premio Mensual Publicación Científica Destacada de la US. Facultad de Medicina | |