Artículo
A metagenome-wide association study of HIV disease progression in HIV controllers
Autor/es | Real, Luis Miguel
Sáez, María E. Corma Gómez, Anaïs González Pérez, Antonio Thorball, Christian Ruiz Laza, Rocío Jiménez León, María Reyes González-Serna Martín, Manuel Alejandro Bachiller, Sara Ruiz Mateos, Ezequiel |
Departamento | Universidad de Sevilla. Departamento de Bioquímica y Biología Molecular Universidad de Sevilla. Departamento de Bioquímica Médica y Biología Molecular e Inmunología Universidad de Sevilla. Departamento de Fisiología |
Fecha de publicación | 2023 |
Fecha de depósito | 2023-07-19 |
Publicado en |
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Resumen | Some HIV controllers experience immunologic progression with CD4+ T cell decline. We aimed to identify genetic factors associated with CD4+ T cell lost in HIV controllers. A total of 561 HIV controllers were included, 442 ... Some HIV controllers experience immunologic progression with CD4+ T cell decline. We aimed to identify genetic factors associated with CD4+ T cell lost in HIV controllers. A total of 561 HIV controllers were included, 442 and 119 from the International HIV controllers Study Cohort and the Swiss HIV Cohort Study, respectively. No SNP or gene was associated with the long-term non-progressor HIV spontaneous control phenotype in the individual GWAS or in the meta-analysis. However, SNPs previously associated with natural HIV control linked to HLA-B (rs2395029 [p = 0.005; OR = 1.70], rs59440261 [p = 0.003; OR = 1.78]), MICA (rs112243036 [p = 0.011; OR = 1.45]), and PSORS1C1 loci (rs3815087 [p = 0.017; OR = 1.39]) showed nominal association with this phenotype. Genetic factors associated with the long-term HIV controllers without risk of immunologic progression are those previously related to the overall HIV controller phenotype. |
Agencias financiadoras | Junta de Andalucía European Union (UE) European Commission (EC). Fondo Europeo de Desarrollo Regional (FEDER) Instituto de Salud Carlos III Agencia Estatal de Investigación. España |
Identificador del proyecto | PI-0001/2017
RD16/0025/0040 RD12/0017/0012 PI16/00684 PI19/01127 PI22/01796 PI10/02635 PI13/0796 PI16/00503 PI19/01337 RD16/0025/0020 RD16/0025/0006 |
Cita | Real, L.M., Sáez, M.E., Corma Gómez, A., González Pérez, A., Thorball, C., Ruiz Laza, R.,...,Ruiz Mateos, E. (2023). A metagenome-wide association study of HIV disease progression in HIV controllers. iScience, 26 (7), 107214. https://doi.org/10.1016/j.isci.2023.107214. |
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