Artículos (Fisiología)
Recent Submissions
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Muscle Progenitors Derived from Extraocular Muscles Express Higher Levels of Neurotrophins and their Receptors than other Cranial and Limb Muscles [Article]
(MDPI, 2020)Extraocular muscles (EOMs) show resistance to muscle dystrophies and sarcopenia. It has been recently demonstrated that they are endowed with different types of myogenic cells, all of which present an outstanding regenerative ...
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Purkinje cell-specific Grip1/2 knockout mice show increased repetitive self-grooming and enhanced mGluR5 signaling in cerebellum [Article]
(Elsevier, 2019)Cerebellar Purkinje cell (PC) loss is a consistent pathological finding in autism. However, neural mechanisms of PC-dysfunction in autism remain poorly characterized. Glutamate receptor interacting proteins 1/2 (Grip1/2) ...
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Beyond Clinical High-Risk State for Psychosis: The Network Structure of Multidimensional Psychosis Liability in Adolescents [Article]
(Frontiers Media, 2020)OBJECTIVES: The main goal of the present study was to analyze the network structure of schizotypy dimensions in a representative sample of adolescents from the general population. Moreover, the network structure between ...
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Extracellular Vesicle-Mediated Communication between the Glioblastoma and Its Microenvironment [Article]
(MDPI, 2019)The glioblastoma is the most malignant form of brain cancer. Glioblastoma cells use multiple ways of communication with the tumor microenvironment in order to tune it for their own benefit. Among these, extracellular ...
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Functional diversity of motoneurons in the oculomotor system [Article]
(National Academy of Sciences, 2019-02-26)Extraocular muscles contain two types of muscle fibers according to their innervation pattern: singly innervated muscle fibers (SIFs), similar to most skeletal muscle fibers, and multiply innervated muscle fibers (MIFs). ...
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Gender and Leadership: an Approach to the Differences between Women and Men in Management [Article]
(Hyperion University of Bucharest, 2014-03)When a group of persons begins to interact, various differences between the members begin to appear. The pattern of relationships change according to the nature of the task and the most influential person became to be the ...
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Predictive Value of Serum Antibodies and Point Mutations of AQP4, AQP1 and MOG in A Cohort of Spanish Patients with Neuromyelitis Optica Spectrum Disorders [Article]
(MDPI, 2019-11-19)The detection of IgG aquaporin-4 antibodies in the serum of patients with Neuromyelitis optica (NMO) has dramatically improved the diagnosis of this disease and its distinction from multiple sclerosis. Recently, a group ...
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Neural Stem Cells of the Subventricular Zone as the Origin of Human Glioblastoma Stem Cells. Therapeutic Implications [Article]
(Frontiers Media, 2019)Human glioblastoma is the most aggressive type of primary malignant brain tumors. Standard treatment includes surgical resection followed by radiation and chemotherapy but it only provides short-term benefits and the ...
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Maternal insulin therapy does not restore foetoplacental endothelial dysfunction in gestational diabetes mellitus [Article]
(Elsevier, 2017)Pregnant women diagnosed with gestational diabetes mellitus subjected to diet (GDMd) that do not reach normal glycaemia are passed to insulin therapy (GDMi). GDMd associates with increased human cationic amino acid transporter ...
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Intracellular acidification reduces L-arginine transport via system y + L but not via system y + /CATs and nitric oxide synthase activity in human umbilical vein endothelial cells [Article]
(Elsevier, 2018)L-Arginine is taken up via the cationic amino acid transporters (system y + /CATs) and system y + L in human umbilical vein endothelial cells (HUVECs). L-Arginine is the substrate for endothelial NO synthase (eNOS) which ...
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Small and large intestine express a truncated Dab1 isoform that assembles in cell-cell junctions and co-localizes with proteins involved in endocytosis [Article]
(Elsevier, 2018)Disabled-1 (Dab1) is an essential intracellular adaptor protein in the reelin pathway. Our previous studies in mice intestine showed that Dab1 transmits the reelin signal to cytosolic signalling pathways. Here, we determine ...
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Importancia curricular de los estudios de bioética en la formación de especialistas en biotecnología animal [Article]
(Universitat Autònoma de Barcelona, 2017)El presente proyecto docente incorpora para el alumnado del grado en Bioquímica de la Facultad de Biología de Sevilla, contenidos específicos de Bioética aplicados al campo de la Biotecnología animal. El objetivo de esta ...
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¿Existe un currículum divulgador? Sensibilización del alumnado de las titulaciones de Biología y Bioquímica ante la importancia social de la comunicación en ciencia [Article]
(Universidad de Valencia ; Universidad Autónoma de Barcelona, 2017)Transmitir conocimiento rigurosamente a la sociedad, es uno de los principales compromisos de la Universidad, en tanto que generadora de saber. Sin embargo, todavía hoy se detecta una implicación muy minoritaria en este ...
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Exosomes derived from monocytes and from endothelial cells mediate monocyte and endothelial cell activation under high d-glucose conditions [Article]
(Elsevier, 2019)Diabetes mellitus type 2 (DMT2) is characterized by hyperglycemia and associated with low grade inflammation affecting both endothelial cells and monocytes. Exosomes are nanovesicles, allow communication between endothelial ...
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Fetoplacental endothelial exosomes modulate high d-glucose-induced endothelial dysfunction [Article]
(Elsevier, 2018)Gestational diabetes mellitus (GDM) is associated with fetoplacental endothelial dysfunction, which may be induced by hyperglycemia. We hypothesized that endothelial exosomes, which are extracellular nanovesicles affecting ...
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Protein Kinase C: Targets to Regenerate Brain Injuries? [Article]
(Frontiers Media, 2019)Acute or chronic injury to the central nervous system (CNS), causes neuronal death and irreversible cognitive deficits or sensory-motor alteration. Despite the capacity of the adult CNS to generate new neurons from neural ...
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Reelin expression is up-regulated in mice colon in response to acute colitis and provides resistance against colitis [Article]
(Elsevier, 2017)Reelin is an extracellular matrix protein first known for its key role in neuronal migration. Studies in rodent small intestine suggested that reelin protects the organism from intestinal pathology. Here we determined in ...
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Reelin protects from colon pathology by maintaining the intestinal barrier integrity and repressing tumorigenic genes [Article]
(Elsevier, 2017)We previously reported that reelin, an extracellular matrix protein first known for its key role in neuronal migration, reduces the susceptibility to dextran sulphate sodium (DSS)-colitis. The aim of the current study was ...
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A Cholinergic Synaptically Triggered Event Participates in the Generation of Persistent Activity Necessary for Eye Fixation [Article]
(Society for Neuroscience, 2004)An exciting topic regarding integrative properties of the nervous system is how transient motor commands or brief sensory stimuli are able to evoke persistent neuronal changes, mainly as a sustained, tonic action potential ...
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Mechanisms of Action and Targets of Nitric Oxide in the Oculomotor System [Article]
(Society for Neuroscience, 1998)Nitric oxide (NO) production by neurons in the prepositus hypoglossi (PH) nucleus is necessary for the normal performance of eye movements in alert animals. In this study, the mechanism(s) of action of NO in the oculomotor ...