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Artículo
Tension in secretory granule membranes causes extensive membrane transfer through the exocytotic fusion pore
(The National Academy of Science, 1990)
or fusion to occur the repulsive forces between two interacting phospholipid bilayers must be reduced. In model systems, this can be achieved by increasing the surface tension of at least one of the membranes. However, ...
Artículo
Preservation of KCC2 expression in axotomized abducens motoneurons and its enhancement by VEGF
(Springer Nature, 2023)
The potassium chloride cotransporter 2 (KCC2) is the main Cl− extruder in neurons. Any alteration in KCC2 levels leads to changes in Cl− homeostasis and, consequently, in the polarity and amplitude of inhibitory synaptic ...
Artículo
Increased novelty-induced locomotion, sensitivity to amphetamine, and extracellular dopamine in striatum of Zdhhc15-deficient mice
(Springer Nature, 2021)
Novelty-seeking behaviors and impulsivity are personality traits associated with several psychiatric illnesses including attention deficits hyperactivity disorders. The underlying neural mechanisms remain poorly understood. ...
Artículo
Decreased Level of Cord Blood Circulating Endothelial Colony-Forming Cells in Preeclampsia
(American Heart Association, 2014)
Preeclampsia is a pregnancy-related disorder associated with increased cardiovascular risk for the offspring. Endothelial colony–forming cells (ECFCs) are a subset of circulating endothelial progenitor cells that participate ...
Artículo
Maternal Body-Mass Index and Cord Blood Circulating Endothelial Colony-Forming Cells
(Elsevier, 2014)
Objective Endothelial colony-forming cells (ECFCs) are a subset of circulating endothelial progenitor cells that are particularly abundant in umbilical cord blood. We sought to determine whether ECFC abundance in cord ...
Artículo
Altered Cortical Palmitoylation Induces Widespread Molecular Disturbances in Parkinson’s Disease
(MDPI, 2022)
The relationship between Parkinson’s disease (PD), the second-most common neurodegenerative disease after Alzheimer’s disease, and palmitoylation, a post-translational lipid modification, is not well understood. In this ...
Artículo
Human white adipose tissue vasculature contains endothelial colony-forming cells with robust in vivo vasculogenic potential
(Springer, 2013)
Blood-derived endothelial colony-forming cells (ECFCs) have robust vasculogenic potential that can be exploited to bioengineer long-lasting human vascular networks in vivo. However, circulating ECFCs are exceedingly rare ...
Artículo
Perturbing HIV-1 Ribosomal Frameshifting Frequency Reveals a cis Preference for Gag-Pol Incorporation into Assembling Virions
(American Society for Microbiology, 2022)
HIV-1 virion production is driven by Gag and Gag-Pol (GP) proteins, with Gag forming the bulk of the capsid and driving budding, while GP binds Gag to deliver the essential virion enzymes protease, reverse transcriptase, ...