Artículo
Decreased Level of Cord Blood Circulating Endothelial Colony-Forming Cells in Preeclampsia
Autor/es | Muñoz Hernández, Rocío
Miranda Guisado, María Luisa Stiefel García-Junco, Pablo Enrique Lin, R.Z. Praena Fernández, Juan Manuel Domínguez Simeón, María J. Villar, José Moreno Luna, Rafael Melero Martín, Juan M. |
Departamento | Universidad de Sevilla. Departamento de Fisiología Universidad de Sevilla. Departamento de Medicina |
Fecha de publicación | 2014 |
Fecha de depósito | 2024-01-19 |
Publicado en |
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Resumen | Preeclampsia is a pregnancy-related disorder associated with increased cardiovascular risk for the offspring. Endothelial colony–forming cells (ECFCs) are a subset of circulating endothelial progenitor cells that participate ... Preeclampsia is a pregnancy-related disorder associated with increased cardiovascular risk for the offspring. Endothelial colony–forming cells (ECFCs) are a subset of circulating endothelial progenitor cells that participate in the formation of vasculature during development. However, the effect of preeclampsia on fetal levels of ECFCs is largely unknown. In this study, we sought to determine whether cord blood ECFC abundance and function are altered in preeclampsia. We conducted a prospective cohort study that included women with normal (n=35) and preeclamptic (n=15) pregnancies. We measured ECFC levels in the umbilical cord blood of neonates and characterized ECFC phenotype, cloning-forming ability, proliferation, and migration toward vascular endothelial growth factor-A and fibroblast growth factor-2, in vitro formation of capillary-like structures, and in vivo vasculogenic ability in immunodeficient mice. We found that the level of cord blood ECFCs was statistically lower in preeclampsia than in control pregnancies (P=0.04), a reduction that was independent of other obstetric factors. In addition, cord blood ECFCs from preeclamptic pregnancies required more time to emerge in culture than control ECFCs. However, once derived in culture, ECFC function was deemed normal and highly similar between preeclampsia and control, including the ability to form vascular networks in vivo. This study demonstrates that preeclampsia affects ECFC abundance in neonates. A reduced level of ECFCs during preeclamptic pregnancies may contribute to an increased risk of developing future cardiovascular events. |
Agencias financiadoras | National Institutes of Health. United States Junta de Andalucía Instituto de Salud Carlos III |
Identificador del proyecto | R00EB009096
SAS111241 P08-CVI-4352 PI10/02473 |
Cita | Muñoz Hernández, R., Miranda Guisado, M.L., Stiefel García-Junco, P.E., Lin, R.Z., Praena Fernández, J.M., Domínguez Simeón, M.J.,...,Melero Martín, J.M. (2014). Decreased Level of Cord Blood Circulating Endothelial Colony-Forming Cells in Preeclampsia. Hypertension, 64 (1), 165-171. https://doi.org/10.1161/HYPERTENSIONAHA.113.03058. |
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