Article
Maternal Body-Mass Index and Cord Blood Circulating Endothelial Colony-Forming Cells
Author/s | Moreno Luna, Rafael
Muñoz Hernández, Rocío Lin, R.Z. Miranda Guisado, María Luisa Vallejo Vaz, Antonio Javier Stiefel García-Junco, Pablo Enrique Praena Fernández, Juan Manuel Bernal Bermejo, José Angel Jiménez Jiménez, Luis Manuel Villar, José Melero Martín, Juan M. |
Department | Universidad de Sevilla. Departamento de Fisiología Universidad de Sevilla. Departamento de Medicina |
Publication Date | 2014 |
Deposit Date | 2024-01-19 |
Published in |
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Abstract | Objective
Endothelial colony-forming cells (ECFCs) are a subset of circulating endothelial progenitor cells that are particularly abundant in umbilical cord blood. We sought to determine whether ECFC abundance in cord ... Objective Endothelial colony-forming cells (ECFCs) are a subset of circulating endothelial progenitor cells that are particularly abundant in umbilical cord blood. We sought to determine whether ECFC abundance in cord blood is associated with maternal body-mass index (BMI) in nonpathologic pregnancies. Study design We measured the level of ECFCs in the cord blood of neonates (n = 27) born from non-obese healthy mothers with nonpathologic pregnancies and examined whether ECFC abundance correlated with maternal BMI. We also examined the effect of maternal BMI on ECFC phenotype and function using angiogenic and vasculogenic assays. Results We observed variation in ECFC abundance among subjects and found a positive correlation between prepregnancy maternal BMI and ECFC content (r = 0.51, P = .007), which was independent of other obstetric factors. Despite this variation, ECFC phenotype and functionality were deemed normal and highly similar between subjects with maternal BMI <25 kg/m2 and BMI between 25-30 kg/m2, including the ability to form vascular networks in vivo. Conclusions This study underlines the need to consider maternal BMI as a potential confounding factor for cord blood levels of ECFCs in future comparative studies between healthy and pathologic pregnancies. |
Funding agencies | Junta de Andalucía National Institutes of Health. United States Instituto de Salud Carlos III |
Project ID. | SAS111241
R00EB009096 PI10/02473 |
Citation | Moreno Luna, R., Muñoz Hernández, R., Lin, R.Z., Miranda Guisado, M.L., Vallejo Vaz, A.J., Stiefel García-Junco, P.E.,...,Melero Martín, J.M. (2014). Maternal Body-Mass Index and Cord Blood Circulating Endothelial Colony-Forming Cells. The Journal of Pediatrics, 164 (3), 566-571. https://doi.org/10.1016/j.jpeds.2013.10.063. |
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