• Article
  

  Editorial: The Role of the Immune Response in Brain Metastasis 

  Sibson, Nicola R.; Thorsen, F.; Sarmiento Soto, Manuel (Frontiers Media S.A., 2022-05-10)
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  Update on Anti-Inflammatory Molecular Mechanisms Induced by Oleic Acid 

  Santa-María Pérez, Consuelo; López Enriquez, Soledad; Montserrat de la Paz, Sergio; Geniz, Isabel; Reyes-Quiroz, Maria Edith; Moreno, Manuela; Palomares, Francisca; Sobrino Beneyto, Francisco; Alba Jiménez, Gonzalo (Multidisciplinary Digital Publishing Institute (MDPI), 2023)

  In 2010, the Mediterranean diet was recognized by UNESCO as an Intangible Cultural Heritage of Humanity. Olive oil is the ...

• Article
  

  Antiproliferative effect of boldine on neural progenitor cells and on glioblastoma cells 

  Jiménez Madrona, Enrique; Morado Díaz, Camilo José; Talaverón Aguilocho, Rocío; Tabernero, Arantxa; Pastor Loro, Ángel Manuel; Sáez, Juan C.; Rodríguez Matarredona, Esperanza (Frontiers Media, 2023)

  The subventricular zone (SVZ) is a brain region that contains neural stem cells and progenitor cells (NSCs/NPCs) from ...

• Article
  

  A metagenome-wide association study of HIV disease progression in HIV controllers 

  Real, Luis Miguel; Sáez, María E.; Corma Gómez, Anaïs; González Pérez, Antonio; Thorball, Christian; Ruiz Laza, Rocío; Jiménez León, María Reyes; González-Serna Martín, Manuel Alejandro; Bachiller, Sara; Ruiz Mateos, Ezequiel (Elsevier, 2023)

  Some HIV controllers experience immunologic progression with CD4+ T cell decline. We aimed to identify genetic factors ...

• Article
  

  Blockade of the Interaction of Calcineurin with FOXO in Astrocytes Protects Against Amyloid-β-Induced Neuronal Death 

  Fernández, Ana M.; Hervás, Rubén; Domínguez Fraile, Manuel; Garrido Navarro, Victoria; Gómez Gutiérrez, Patricia; Vega, Miguel; Torres Alemán, Ignacio; Vitorica Ferrández, Francisco Javier (IOS Press, 2016-06-07)

  Astrocytes actively participate in neuro-inflammatory processes associated to Alzheimer’s disease (AD), and other brain ...

• Article
  

  Docosahexaenoic acid reduces microglia phagocytic activity via miR-124 and induces neuroprotection in rodent models of spinal cord contusion injury 

  Burguillos García, Miguel Ángel; Kei Yip, Ping; Bowes, Amy L.; Hall, Jodie C.E.; Richard Ip, T.H.; Baskerville, Tracey; Liu, Zhuo Hao; Michael-Titus, Adina T. (Oxford University Press, 2019-07-15)

  Microglia are activated after spinal cord injury (SCI), but their phagocytic mechanisms and link to neuroprotection remain ...

• Article
  

  Apoptosis-inducing factor mediates dopaminergic cell death in response to LPS-induced inflammatory stimulus: Evidence in Parkinson's disease patients 

  Burguillos García, Miguel Ángel; Hajji, Nabil; Englund, Elisabet; Persson, Annette; Cenci, Maria Angela; Machado, Alberto; Cano, Josefina; Joseph, Bertrand; Venero Recio, José Luis (Elsevier, 2011-01)

  We show that intranigral lipopolysaccharide (LPS) injection, which provokes specific degeneration of DA neurons, induced ...

• Article
  

  Genetic Rescue of Mitochondrial and Skeletal Muscle Impairment in an Induced Pluripotent Stem Cells Model of Coenzyme Q10 Deficiency 

  Romero Moya, Damià; Santos Ocaña, Carlos; Castaño, Julio; Garrabou, Gloria; Rodríguez Gómez, José Antonio; Ruiz Bonilla, Vanesa; Bueno, Clara; González Rodríguez, Patricia; Giorgetti, Alessandra; Perdiguero, Eusebio; Prieto, Cristina; Moren Núñez, Constanza; Fernández Ayala, Daniel J.; Victoria Cascajo, María; Velasco, Iván; Canals, Josep María; Montero, Raquel; Yubero, Delia; Jou, Cristina; López Barneo, José; Cardellac, Francesc; Muñoz Cánoves, Pura; Artuch, Rafael; Navas, Plácido; Menéndez, Pablo (Wiley-Blackwell, 2017-07)

  Coenzyme Q10 (CoQ10) plays a crucial role in mitochondria as an electron carrier within the mitochondrial respiratory chain ...

• Article
  

  Metabolomic screening of regional brain alterations in the APP/PS1 transgenic model of Alzheimer's disease by direct infusion mass spectrometry 

  Vitorica Ferrández, Francisco Javier; González Domínguez, Raúl; García Barrera, Tamara; Gómez Ariza, José Luis (Elsevier, 2015-01-05)

  The identification of pathological mechanisms underlying to Alzheimer's disease is of great importance for the discovery ...

• Article
  

  Microglial Caspase-3 is essential for modulating hippocampal neurogenesis. 

  Alonso Bellido, Isabel María; Posada Pérez, Mercedes; Hernández Rasco, Francisco; Vázquez Reyes, Sandra; Cabanillas, María; Herrera Carmona, Antonio José; Soldán Hidalgo, Jesús; Espinosa Oliva, Ana María; Martínez de Pablos, Rocío; Venero Recio, José Luis; Ruiz Laza, Rocío (Elsevier, 2023)

  Adult hippocampal neurogenesis (AHN) is a process involved in numerous neurodegenerative diseases. Many researchers have ...

• Article
  

  Galectin-3 shapes toxic alpha-synuclein strains in Parkinson's disease. 

  García Revilla, Juan; Boza Serrano, Antonio; Jin, Yiyun; Vadukul, Devkee M.; Soldán Hidalgo, Jesús; Camprubí Ferrer, Lluís; Ruiz Laza, Rocío; Venero Recio, José Luis (Springer, 2023)

  Parkinson’s Disease (PD) is a neurodegenerative and progressive disorder characterised by intracytoplasmic inclusions ...

• Article
  

  Impact of evening carbohydrate intake on the resolution of persistent night sweats in patients with long COVID: a case series 

  García Quintanilla, Alberto; Rivera Izquierdo, Mario; García Quintanilla, Meritxell de Jesús (Taylor & Francis, 2023)

  Up to 25% of patients with long COVID experience persistent night sweats. However, in most cases they remain untreated ...

• Article
  

  Galectin-3 is elevated in CSF and is associated with A beta deposits and tau aggregates in brain tissue in Alzheimer's disease 

  Boza Serrano, Antonio; Vrillon, Agathe; Minta, Karolina; Paulus, Agnes; Camprubí Ferrer, Lluís; García, Megg; Vitorica Ferrández, Francisco Javier; Venero Recio, José Luis; Deierborg, Tomas (Springer, 2022)

  Galectin-3 (Gal-3) is a beta-galactosidase binding protein involved in microglial activation in the central nervous ...

• Article
  

  The combined partial knockdown of CBS and MPST genes induces inflammation, impairs adipocyte function-related gene expression and disrupts protein persulfidation in human adipocytes 

  Latorre, Jessica; Aroca Aguilar, Ángeles; Fernández Real, José Manuel; Romero , Luis C.; Moreno Navarrete, José María (MDPI, 2022)

  Recent studies in mice and humans demonstrated the relevance of H2S synthesising enzymes, such as CTH, CBS, and MPST, in ...

• Article
  

  Cysteine string protein-α is essential for the high calciumsensitivity of exocytosis in a vertebrate synapse 

  Ruiz Laza, Rocío; Casañas, J. J.; Südhof, T. C.; Tabares, Lucía (Wiley, 2008)

  Cysteine string protein (CSPa) is a synaptic vesicle protein present in most central and peripheral nervous system ...

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  ARG1-expressing microglia show a distinct molecular signature and modulate postnatal development and function of the mouse brain 

  Stratoulias, Vassilis; Ruiz Laza, Agustín; Kanatani, Shigeaki; Osman, Ahmed Mohamed; Keane, Lily; Armengol, Jose A.; García Domínguez, Irene; Alonso Bellido, Isabel María; Venero Recio, José Luis; Joseph, Bertrand (Nature Research, 2023)

  Molecular diversity of microglia, the resident immune cells in the CNS, is reported. Whether microglial subsets characterized ...

• Article
  

  Synaptic defects in spinal muscular atrophy animal models 

  Torres-Benito, Laura; Ruiz Laza, Rocío; Tabares, Lucía (Wiley, 2011)

  Proximal spinal muscular atrophy, the most frequent genetic cause of childhood lethality, is caused by homozygous loss ...

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  Monocyte-derived Cells Invade Brain Parenchyma and Amyloid Plaques in Human Alzheimer’s Disease Hippocampus 

  Muñoz-Castro, Clara; Mejías Ortega, Marina; Sánchez Mejías, Elisabeth; Navarro Garrido, Victoria; Trujillo Estrada, Laura; Jiménez, Sebastián; García León, Juan Antonio; Fernández Valenzuela, Juan José; Sánchez Mico, María Virtudes; Romero Molina, Carmen; Moreno González, Inés; Baglietto Vargas, David; Vizuete Chacón, María Luisa; Gutiérrez, Antonia; Vitorica Ferrández, Francisco Javier (Springer Nature, 2023)

  Microglia are brain-resident myeloid cells and play a major role in the innate immune responses of the CNS and the ...

• Article
  

  Morphological and functional remodelling of the neuromuscular junction by skeletal muscle PGC-1 alpha 

  Arnold, Anne Sophie; Gill, Jonathan; Christe, Martine; Ruiz Laza, Rocío; McGuirk, Shawn; St-Pierre, Julie; Tabares, Lucía; Handschin, Christoph (NATURE PUBLISHING GROUP, 2014-04-04)

  The neuromuscular junction (NMJ) exhibits high morphological and functional plasticity. In the mature muscle, the relative ...

• Article
  

  Active zones and the readily releasable pool of synaptic vesicles at the neuromuscular junction of the mouse 

  Ruiz Laza, Rocío; Cano, Raquel; Casañas, Juan José; Gaffield, Michael A.; Betz, William J.; Tabares, Lucía (SOC NEUROSCIENCE, 2011-02-09)

  Synchronous neurotransmitter releaseis a highly regulated processthattakes place at specializations atthe presynapticmembrane ...

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