Recent Submissions

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    Neocortical tissue recovery in severe congenital obstructive hydrocephalus after intraventricular administration of bone marrow-derived mesenchymal stem cells  [Article]

    García Bonilla, María; García Martín, María L.; Ojeda Pérez, Betsaida; Muñoz Hernández, Mª Carmen; Vitorica Ferrández, Francisco Javier; Jiménez Muñoz, Sebastián; Cifuentes, Manuel; Santos Ruíz, Leonor; Shumilov, Kirill; Claros, Silvia; Páez González, Patricia; Jiménez, Antonio J. (BMC, 2020)
    BACKGROUND: In obstructive congenital hydrocephalus, cerebrospinal fluid accumulation is associated with high intracranial pressure and the presence of periventricular edema, ischemia/hypoxia, damage of the white matter, ...
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    TET2, an ambiguous player in inflammation  [Article]

    Espinosa Oliva, Ana María; Burguillos García, Miguel Ángel (2020)
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    Microglial subtypes: diversity within the microglial community  [Article]

    Venero Recio, José Luis; Stratoulias, Vassilis; Tremblay, Marie-Ève; Joseph, Bertrand (EMBO Press, 2019)
    Microglia are brain-resident macrophages forming the first active immune barrier in the central nervous system. They fulfill multiple functions across development and adulthood and under disease conditions. Current ...
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    Brainiac Caspases: Beyond the Wall of Apoptosis  [Article]

    Espinosa Oliva, Ana María; García Revilla, Juan; Alonso Bellido, Isabel María; Burguillos García, Miguel Ángel (Frontiers Media, 2019)
    For the last two decades, caspases, a family of cysteine-aspartic proteases, have evolved from being considered solely as regulators of apoptosis or inflammation to having a wider range of functions. In this mini review, ...
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    Reformulating Pro-Oxidant Microglia in Neurodegeneration  [Article]

    García Revilla, Juan; Alonso Bellido, Isabel María; Burguillos García, Miguel Ángel; Herrera Carmona, Antonio José; Espinosa Oliva, Ana María; Cruz Hernández, Luis; García Domínguez, Irene; Roca Ceballos, María Angustias; Venero Recio, José Luis; Sarmiento Soto, Manuel (MDPI, 2019)
    In neurodegenerative diseases, microglia-mediated neuroinflammation and oxidative stress are central events. Recent genome-wide transcriptomic analyses of microglial cells under different disease conditions have uncovered ...
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    TET2 Regulates the Neuroinflammatory Response in Microglia  [Article]

    Carrillo Jiménez, Alejandro; Ruiz-Laza, Rocío; García Domínguez, Irene; García Revilla, Juan; Espinosa Oliva, Ana María; Venero Recio, José Luis; Burguillos García, Miguel Ángel; Tayara, Khadija (Elsevier, 2019)
    Epigenomic mechanisms regulate distinct aspects of the inflammatory response in immune cells. Despite the central role for microglia in neuroinflammation and neurodegeneration, little is known about their epigenomic ...
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    SIRT1 activation with neuroheal is neuroprotective but SIRT2 inhibition with AK7 is detrimental for disconnected motoneurons  [Article]

    Romeo Guitart, David; Leiva Rodríguez, Tatiana; Espinosa Alcantud, María; Sima, Núria; Vaquero, Alejandro; Domínguez Martín, Helena; Ruano Caballero, Diego; Casas, Catalina (Springer Nature, 2018)
    Sirtuin 1 (SIRT1) activity is neuroprotective, and we have recently demonstrated its role in the retrograde degenerative process in motoneurons (MNs) in the spinal cord of rats after peripheral nerve root avulsion (RA) ...
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    Magnetofection as a new tool to study microglia biology  [Article]

    Venero Recio, José Luis; Burguillos García, Miguel Ángel (Medknow Publications, 2019)
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    Uric acid enhances longevity and endurance and protects the brain against ischemia  [Article]

    Cutler, Roy G.; Camandola, Simonetta; Feldman, Neil H.; Seon Yoon, Jeong; Haran, James B.; Argüelles Castilla, Sandro; Mattsona, Mark P. (Elsevier, 2019)
    Among mammals, there is a positive correlation between serum uric acid (UA) levels and life span. Humans have high levels of UA because they lack a functional urate oxidase (UOX) enzyme that is present in shorter lived ...
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    Molecular Control of the Amount, Subcellular Location and Activity State of Translation Elongation Factor 2 (eEF-2) in Neurons Experiencing Stress  [Article]

    Argüelles Castilla, Sandro; Camandola, Simonetta; Hutchison, Emmette R.; Cutler, Roy G.; Ayala Gómez, Antonio (Eslsevier, 2013)
    Eukaryotic elongation factor 2 (eEF-2) is an important regulator of the protein translation machinery wherein it controls the movement of the ribosome along the mRNA. The activity of eEF-2 is regulated by changes in cellular ...
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    Stress Increases Vulnerability to Inflammation in the Rat Prefrontal Cortex  [Article]

    Martínez de Pablos, Rocío; Fernández Villarán, Ruth; Argüelles Castilla, Sandro; Herrera Carmona, Antonio José; Venero Recio, José Luis; Ayala Gómez, Antonio (Society for Neuroscience, 2006)
    Inflammation could be involved in some neurodegenerative disorders that accompany signs of inflammation. However, because sensitivity to inflammation is not equal in all brain structures, a direct relationship is not clear. ...
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    Elongation factor 2-diphthamide is critical for translation of two IRES-dependent protein targets, XIAP and FGF2, under oxidative stress conditions  [Article]

    Argüelles Castilla, Sandro; Camandola, Simonetta; Cutler, Roy G.; Ayala Gómez, Antonio (Elsevier, 2013)
    Elongation factor-2 (eEF2) catalyzes the movement of the ribosome along the mRNA. A single histidine residue in eEF2 (H715) is modified to form diphthamide. A role for eEF2 in cellular stress responses is highlighted by ...
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    Distinct Microglial Responses in Two Transgenic Murine Models of TAU Pathology  [Article]

    Romero Molina, Carmen; Navarro Garrido, Victoria; Sánchez Varo, Raquel María; Jiménez Muñoz, Sebastián; Fernández Valenzuela, Juan José; Sánchez Mico, María; Muñoz Castro, Clara; Gutiérrez, Antonia; Vitorica Ferrández, Francisco Javier; Vizuete Chacón, María Luisa (Frontiers Media Research Foundation, 2018-11-14)
    Microglial cells are crucial players in the pathological process of neurodegenerative diseases, such as Alzheimer’s disease (AD). Microglial response in AD has been principally studied in relation to amyloid-beta pathology ...
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    Peripheral Inflammation Enhances Microglia Response and Nigral Dopaminergic Cell Death in an in vivo MPTP Model of Parkinson’s Disease  [Article]

    García Domínguez, Irene; Veselá, Karolina; García Revilla, Juan; Carrillo Jiménez, Alejandro; Roca Ceballos, María Angustias; Santiago, Marti; Martínez de Pablos, Rocío; Venero Recio, José Luis (Frontiers Media, 2018)
    The impact of systemic inflammation in nigral dopaminergic cell loss remains unclear. Here, we have investigated the role of peripheral inflammation induced by systemic lipopolysaccharide (LPS) administration in the ...
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    Divergent Effects of Metformin on an Inflammatory Model of Parkinson’s Disease  [Article]

    Tayara, Khadija; Espinosa Oliva, Ana María; García Domínguez, Irene; Ismaiel, Afrah Abdul; Boza Serrano, Antonio; Deierborg, Tomas; Martínez de Pablos, Rocío; Machado de la Quintana, Alberto; Herrera Carmona, Antonio José; Venero Recio, José Luis (Frontiers Media, 2018)
    The oral antidiabetic drug metformin is known to exhibit anti-inflammatory properties through activation of AMP kinase, thus protecting various brain tissues as cortical neurons, for example. However, the effect of metformin ...
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    The Multifarious Role of Microglia in Brain Metastasis  [Article]

    Sarmiento Soto, Manuel; Sibson, Nicola R. (Frontiers Media, 2018)
    The immune landscape in brain metastasis is a very heterogeneous framework. Amongst a broad plethora of cells within the tumor microenvironment, the presence of activated microglia has been perfectly described. The innate ...
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    Effective Knockdown of Gene Expression in Primary Microglia With siRNA and Magnetic Nanoparticles Without Cell Death or Inflammation  [Article]

    Carrillo Jiménez, Alejandro; Puigdellívol, Mar; Vilalta, Anna; Venero Recio, José Luis; Brown, Charles Guy; Burguillos García, Miguel Ángel (Frontiers Media, 2018)
    Microglia, the resident immune cells of the brain, have multiple functions in physiological and pathological conditions, including Alzheimer’s disease (AD). The use of primary microglial cell cultures has proved to be a ...
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    RIPK1 is a critical modulator of both tonic and TLR-responsive inflammatory and cell death pathways in human macrophage differentiation  [Article]

    Buchrieser, Julian; Oliva Martín, María José; Moore, Michael D.; Long, Joshua C. D.; Cowley, Sally A.; Long, Joshua C. D.; Pérez Simón, José Antonio; Venero Recio, José Luis (Springer Nature, 2018)
    In this study, we took advantage of human-induced pluripotent stem cells (hiPSC) and CRISPR/Cas9 technology to investigate the potential roles of RIPK1 in regulating hematopoiesis and macrophage differentiation, proinflammatory ...
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    Vasoactive intestinal peptide induces regulatory dendritic cells with therapeutic effects on autoimmune disorders  [Article]

    Chorny, Alejo; Gonzalez-Rey, Elena; Fernandez-Martin, Amelia; Pozo Pérez, David; Ganea, Doina; Delgado, Mario (National Academy of Sciences, 2005)
    The induction of antigen-specific tolerance is critical for the prevention of autoimmunity and maintenance of immune tolerance. In addition to their classical role as sentinels of the immune-response-inducing T cell ...
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    Regional difference in inflammatory response to LPS-injection in the brain: Role of microglia cell density  [Article]

    Pintado Losa, Cristina; Revilla Torres, María Elisa; Vizuete Chacón, María Luisa; García Cuervo, Luisa; Vitorica Ferrández, Francisco Javier; Ruano Caballero, Diego; Castaño Navarro, Angélica (Elsevier, 2011)
    To elucidate whether density of cells could contribute to the extent of microglial activation, we performed in vitro assays using three different densities of N13 microglia stimulated with LPS. Our results showed that ...

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