NameBachiller, Sara
DepartmentBioquímica Médica y Biología Molecular e Inmunología
Knowledge areaBioquímica y Biología Molecular
Professional categoryInvestigadora Contratada (Ramón y Cajal)
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LPS priming before plaque deposition impedes microglial activation and restrains Abeta pathology in the 5xFAD mouse model of Alzheimer's disease.

Yang, Yiyi; García Cruzado, Marta; Zeng, Hairuo; Camprubi Ferrer, Lluis; Bahatyrevich Kharitonik, Bazhena; Bachiller, Sara; Deierborg, Tomas (Elsevier, 2023)
Microglia have an innate immunity memory (IIM) with divergent functions in different animal models of neurodegenerative ...
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A metagenome-wide association study of HIV disease progression in HIV controllers

Real, Luis Miguel; Sáez, María E.; Corma Gómez, Anaïs; González Pérez, Antonio; Thorball, Christian; Ruiz Laza, Rocío; Jiménez León, María Reyes; González-Serna Martín, Manuel Alejandro; Bachiller, Sara; Ruiz Mateos, Ezequiel (Elsevier, 2023)
Some HIV controllers experience immunologic progression with CD4+ T cell decline. We aimed to identify genetic factors ...
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Targeting galectin-3 to counteract spike-phase uncoupling of fast-spiking interneurons to gamma oscillations in Alzheimer’s disease

Bachiller, Sara; Ruiz Laza, Rocío; Boza Serrano, Antonio; Rodríguez-Moreno, Antonio; Deierborg, Tomas; Fisahn, André (2023)
Background Alzheimer’s disease (AD) is a progressive multifaceted neurodegenerative disorder for which no disease-modifying ...
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Early-life stress elicits peripheral and brain immune activation differently in wild type and 5xFAD mice in a sex-specific manner

Bachiller, Sara; Hidalgo, Isabel; Garcia, M. G.; Boza Serrano, Antonio; Paulus, Agnes; Denis, Q.; Haikal, C.; Manouchehrian, O.; Klementieva, O.; Li, J. Y.; Pronk, C. J.; Gouras, G. K.; Deierborg, Tomas (BMC, 2022)
Background The risk of developing Alzheimer’s disease (AD) is modulated by genetic and environmental factors. Early-life ...
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Immune defects associated with lower SARS-CoV-2 BNT162b2 mRNA vaccine response in aged people

Vitalle, Joana; Pérez Gómez, Alberto; Ostos Marcos, Francisco José; Gasca-Capote, Carmen; Jiménez León, María Reyes; Bachiller, Sara; López Cortés, Luis Fernando; Rafii-El-Idrissi Benhnia, Mohammed; Ruiz Mateos, Ezequiel (Journal of clinical investigation, 2022)
The immune factors associated with impaired SARS-CoV-2 vaccine response in elderly people are mostly unknown. We studied ...
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Acute systemic LPS-exposure impairs perivascular CSF distribution in mice

Manouchehrian, O.; Ramos, M.; Bachiller, Sara; Lundgaard, I.; Deierborg, T. (Biomed Central LTD, 2021)
The exchange of cerebrospinal (CSF) and interstitial fluid is believed to be vital for waste clearance in the brain. The ...
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The Other Side of SARS-CoV-2 Infection: Neurological Sequelae in Patients

Alonso Bellido, Isabel María; Bachiller, Sara; Vázquez, Guillermo; Cruz Hernández, Luis; Martínez, Emilio; Ruiz Mateos, Ezequiel; Deierborg, Tomas; Venero Recio, José Luis; Real, Luis Miguel; Ruiz Laza, Rocío (Frontiers Media S.A., 2021)
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has spread around the globe causing coronavirus disease ...
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The effect of electroconvulsive therapy on neuroinflammation, behavior and amyloid plaques in the 5xFAD mouse model of Alzheimer's disease

Svensson, M; Olsson, G; Yang, YY; Bachiller, Sara; Ekemohn, M; Deierborg, T (Nature Publishing Group, 2021)
Microglial cells are affected in Alzheimer’s disease (AD) and interact with amyloid-beta (Aβ) plaques. Apart from memory ...
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The HERC proteins and the nervous system

Pérez Villegas, Eva María; Ruiz Laza, Rocío; Bachiller, Sara; Ventura, Francesc; Armengol, Jose A.; Rosa, Jose Luis (Elsevier, 2021)
The HERC protein family is one of three subfamilies of Homologous to E6AP C-terminus (HECT) E3 ubiquitin ligases. Six HERC ...
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The Ubiquitin Proteasome System in Neuromuscular Disorders: Moving Beyond Movement

Bachiller, Sara; Alonso Bellido, Isabel María; Real, Luis Miguel; Pérez Villegas, Eva María; Venero Recio, José Luis; Deierborg, Tomas; Armengol, José Ángel; Ruiz Laza, Rocío (Multidisciplinary Digital Publishing Institute (MDPI), 2020)
Neuromuscular disorders (NMDs) affect 1 in 3000 people worldwide. There are more than 150 different types of NMDs, where ...
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HERC1 Ubiquitin Ligase Is Required for Normal Axonal Myelination in the Peripheral Nervous System

Bachiller, Sara; Roca Ceballos, María Angustias; García Domínguez, Irene; Pérez Villegas, Eva María; Martos Carmona, David; Pérez Castro, Miguel Ángel; Real Navarrete, Luis Miguel; Rosa, José Luis; Tabares, Lucía; Venero Recio, José Luis; Armengol, José Ángel; Carrión, Ángel Manuel; Ruiz Laza, Rocío (Springer, 2018)
A missense mutation in HERC1 provokes loss of cerebellar Purkinje cells, tremor, and unstable gait in tambaleante (tbl) ...
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HERC 1 Ubiquitin Ligase Mutation Affects Neocortical, CA3 Hippocampal and Spinal Cord Projection Neurons: An Ultrastructural Study

Ruiz Laza, Rocío; Pérez Villegas, Eva María; Bachiller, Sara; Rosa, José Luis; Armengol, Jose Ángel (Frontiers Media, 2016)
The spontaneous mutation tambaleante is caused by the Gly483Glu substitution in the highly conserved N terminal RCC1-like ...