Artículo
Immune defects associated with lower SARS-CoV-2 BNT162b2 mRNA vaccine response in aged people
Autor/es | Vitalle, Joana
Pérez Gómez, Alberto Ostos Marcos, Francisco José ![]() ![]() ![]() ![]() ![]() ![]() ![]() Gasca-Capote, Carmen Jiménez León, María Reyes Bachiller, Sara ![]() ![]() ![]() ![]() ![]() ![]() López Cortés, Luis Fernando ![]() ![]() ![]() ![]() ![]() ![]() Rafii-El-Idrissi Benhnia, Mohammed ![]() ![]() ![]() ![]() ![]() ![]() ![]() Ruiz Mateos, Ezequiel |
Departamento | Universidad de Sevilla. Departamento de Bioquímica Médica y Biología Molecular e Inmunología Universidad de Sevilla. Departamento de Medicina |
Fecha de publicación | 2022 |
Fecha de depósito | 2023-06-15 |
Publicado en |
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Resumen | The immune factors associated with impaired SARS-CoV-2 vaccine response in elderly people are
mostly unknown. We studied individuals older than 60 and younger than 60 years, who had been
vaccinated with SARS-CoV-2 ... The immune factors associated with impaired SARS-CoV-2 vaccine response in elderly people are mostly unknown. We studied individuals older than 60 and younger than 60 years, who had been vaccinated with SARS-CoV-2 BNT162b2 mRNA, before and after the first and second dose. Aging was associated with a lower anti–RBD IgG levels and a decreased magnitude and polyfunctionality of SARS-CoV-2–specific T cell response. The dramatic decrease in thymic function in people > 60 years, which fueled alteration in T cell homeostasis, and their lower CD161+ T cell levels were associated with decreased T cell response 2 months after vaccination. Additionally, deficient DC homing, activation, and TLR-mediated function, along with a proinflammatory functional profile in monocytes, were observed in the > 60-year-old group, which was also related to lower specific T cell response after vaccination. These findings might be relevant for the improvement of the current vaccination strategies and for the development of new vaccine prototypes. |
Agencias financiadoras | Instituto de Salud Carlos III European Commission (EC). Fondo Europeo de Desarrollo Regional (FEDER) |
Identificador del proyecto | PI19/01127
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Cita | Vitalle, J., Pérez Gómez, A., Ostos Marcos, F.J., Gasca-Capote, C., Jiménez León, M.R., Bachiller, S.,...,Ruiz Mateos, E. (2022). Immune defects associated with lower SARS-CoV-2 BNT162b2 mRNA vaccine response in aged people. JCI insight, 7 (17), e161045. https://doi.org/10.1172/jci.insight.161045. |
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