dc.creator | Vitalle, Joana | es |
dc.creator | Pérez Gómez, Alberto | es |
dc.creator | Ostos Marcos, Francisco José | es |
dc.creator | Gasca-Capote, Carmen | es |
dc.creator | Jiménez León, María Reyes | es |
dc.creator | Bachiller, Sara | es |
dc.creator | López Cortés, Luis Fernando | es |
dc.creator | Rafii-El-Idrissi Benhnia, Mohammed | es |
dc.creator | Ruiz Mateos, Ezequiel | es |
dc.date.accessioned | 2023-06-15T13:25:38Z | |
dc.date.available | 2023-06-15T13:25:38Z | |
dc.date.issued | 2022 | |
dc.identifier.citation | Vitalle, J., Pérez Gómez, A., Ostos Marcos, F.J., Gasca-Capote, C., Jiménez León, M.R., Bachiller, S.,...,Ruiz Mateos, E. (2022). Immune defects associated with lower SARS-CoV-2 BNT162b2 mRNA vaccine response in aged people. JCI insight, 7 (17), e161045. https://doi.org/10.1172/jci.insight.161045. | |
dc.identifier.issn | 2379-3708 | es |
dc.identifier.uri | https://hdl.handle.net/11441/147263 | |
dc.description.abstract | The immune factors associated with impaired SARS-CoV-2 vaccine response in elderly people are
mostly unknown. We studied individuals older than 60 and younger than 60 years, who had been
vaccinated with SARS-CoV-2 BNT162b2 mRNA, before and after the first and second dose. Aging
was associated with a lower anti–RBD IgG levels and a decreased magnitude and polyfunctionality
of SARS-CoV-2–specific T cell response. The dramatic decrease in thymic function in people >
60 years, which fueled alteration in T cell homeostasis, and their lower CD161+
T cell levels were
associated with decreased T cell response 2 months after vaccination. Additionally, deficient DC
homing, activation, and TLR-mediated function, along with a proinflammatory functional profile
in monocytes, were observed in the > 60-year-old group, which was also related to lower specific T
cell response after vaccination. These findings might be relevant for the improvement of the current
vaccination strategies and for the development of new vaccine prototypes. | es |
dc.description.sponsorship | Junta de Andalucía | es |
dc.format | application/pdf | es |
dc.format.extent | 21 p. | es |
dc.language.iso | eng | es |
dc.publisher | Journal of clinical investigation | es |
dc.relation.ispartof | JCI insight, 7 (17), e161045. | |
dc.rights | Atribución 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.subject | Immune defects | es |
dc.subject | SARS-CoV-2 BNT162b2 mRNA vaccine | es |
dc.subject | Aged people | es |
dc.subject | Vaccine | es |
dc.title | Immune defects associated with lower SARS-CoV-2 BNT162b2 mRNA vaccine response in aged people | es |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Bioquímica Médica y Biología Molecular e Inmunología | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Medicina | es |
dc.relation.projectID | PI19/01127 | es |
dc.relation.publisherversion | https://insight.jci.org/articles/view/161045 | es |
dc.identifier.doi | 10.1172/jci.insight.161045 | es |
dc.journaltitle | JCI insight | es |
dc.publication.volumen | 7 | es |
dc.publication.issue | 17 | es |
dc.publication.initialPage | e161045 | es |
dc.contributor.funder | Instituto de Salud Carlos III | es |
dc.contributor.funder | European Commission (EC). Fondo Europeo de Desarrollo Regional (FEDER) | es |