dc.creator | Real, Luis Miguel | es |
dc.creator | Sáez, María E. | es |
dc.creator | Corma Gómez, Anaïs | es |
dc.creator | González Pérez, Antonio | es |
dc.creator | Thorball, Christian | es |
dc.creator | Ruiz Laza, Rocío | es |
dc.creator | Jiménez León, María Reyes | es |
dc.creator | González-Serna Martín, Manuel Alejandro | es |
dc.creator | Bachiller, Sara | es |
dc.creator | Ruiz Mateos, Ezequiel | es |
dc.date.accessioned | 2023-07-19T10:25:15Z | |
dc.date.available | 2023-07-19T10:25:15Z | |
dc.date.issued | 2023 | |
dc.identifier.citation | Real, L.M., Sáez, M.E., Corma Gómez, A., González Pérez, A., Thorball, C., Ruiz Laza, R.,...,Ruiz Mateos, E. (2023). A metagenome-wide association study of HIV disease progression in HIV controllers. iScience, 26 (7), 107214. https://doi.org/10.1016/j.isci.2023.107214. | |
dc.identifier.issn | 2589-0042 | es |
dc.identifier.uri | https://hdl.handle.net/11441/148082 | |
dc.description.abstract | Some HIV controllers experience immunologic progression with CD4+ T cell decline. We aimed to identify genetic factors associated with CD4+ T cell lost in HIV controllers. A total of 561 HIV controllers were included, 442 and 119 from the International HIV controllers Study Cohort and the Swiss HIV Cohort Study, respectively. No SNP or gene was associated with the long-term non-progressor HIV spontaneous control phenotype in the individual GWAS or in the meta-analysis. However, SNPs previously associated with natural HIV control linked to HLA-B (rs2395029 [p = 0.005; OR = 1.70], rs59440261 [p = 0.003; OR = 1.78]), MICA (rs112243036 [p = 0.011; OR = 1.45]), and PSORS1C1 loci (rs3815087 [p = 0.017; OR = 1.39]) showed nominal association with this phenotype. Genetic factors associated with the long-term HIV controllers without risk of immunologic progression are those previously related to the overall HIV controller phenotype. | es |
dc.description.sponsorship | Junta de Andalucía (PI-0001/2017) | es |
dc.description.sponsorship | Plan Nacional de I + D + I cofinanced by ISCIII-Subdirección General de Evaluación and Fondo Europeo de Desarrollo Regional (FEDER) co-funded by the European Union (RD16/0025/ 0040, RD12/0017/0012) | es |
dc.description.sponsorship | Instituto de Salud Carlos III, Fondos Europeos para el Desarrollo Regional, FEDER, co-funded by the European Union grants PI16/00684, PI19/01127, PI22/ 01796, PI10/02635, PI13/0796, PI16/00503 and PI19/01337 | es |
dc.description.sponsorship | RETICS, Red de Investigación en SIDA co-funded by the European Union (RD16/0025/0020, RD16/0025/0006-ISCIII-FEDER) | es |
dc.format | application/pdf | es |
dc.format.extent | 12 p. | es |
dc.language.iso | eng | es |
dc.publisher | Elsevier | es |
dc.relation.ispartof | iScience, 26 (7), 107214. | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.title | A metagenome-wide association study of HIV disease progression in HIV controllers | es |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Bioquímica y Biología Molecular | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Bioquímica Médica y Biología Molecular e Inmunología | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Fisiología | es |
dc.relation.projectID | PI-0001/2017 | es |
dc.relation.projectID | RD16/0025/0040 | es |
dc.relation.projectID | RD12/0017/0012 | es |
dc.relation.projectID | PI16/00684 | es |
dc.relation.projectID | PI19/01127 | es |
dc.relation.projectID | PI22/01796 | es |
dc.relation.projectID | PI10/02635 | es |
dc.relation.projectID | PI13/0796 | es |
dc.relation.projectID | PI16/00503 | es |
dc.relation.projectID | PI19/01337 | es |
dc.relation.projectID | RD16/0025/0020 | es |
dc.relation.projectID | RD16/0025/0006 | es |
dc.relation.publisherversion | https://dx.doi.org/10.1016/j.isci.2023.107214 | es |
dc.identifier.doi | 10.1016/j.isci.2023.107214 | es |
dc.journaltitle | iScience | es |
dc.publication.volumen | 26 | es |
dc.publication.issue | 7 | es |
dc.publication.initialPage | 107214 | es |
dc.contributor.funder | Junta de Andalucía | es |
dc.contributor.funder | European Union (UE) | es |
dc.contributor.funder | European Commission (EC). Fondo Europeo de Desarrollo Regional (FEDER) | es |
dc.contributor.funder | Instituto de Salud Carlos III | es |
dc.contributor.funder | Agencia Estatal de Investigación. España | es |