Perfil del autor: Ruiz Laza, Rocío
Datos institucionales
| Nombre | Ruiz Laza, Rocío |
| Departamento | Bioquímica y Biología Molecular |
| Área de conocimiento | Bioquímica y Biología Molecular |
| Categoría profesional | Profesora Titular de Universidad |
| Correo electrónico | Solicitar |
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Estadísticas
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Nº publicaciones
36
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Nº visitas
4305
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Nº descargas
6449
| Publicaciones |
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Artículo
 Inflammatory bowel disease induces pathologicalα-synucleinaggregation in the human gut and brain
(Wiley, 2024)
Aims According to Braak's hypothesis, it is plausible that Parkinson's disease (PD) originates in the enteric nervous ... |
Artículo
Caecum OX40+CD4 T-cell subset associates with mucosal damage and key markers of disease in treated HIV-infection
(Elsevier, 2023)
Background Blood OX40-expressing CD4 T-cells from antiretroviral (ART)-treated people living with HIV (PWH) were found to ... |
Artículo
A metagenome-wide association study of HIV disease progression in HIV controllers
(Elsevier, 2023)
Some HIV controllers experience immunologic progression with CD4+ T cell decline. We aimed to identify genetic factors ... |
Artículo
 Galectin-3 shapes toxic alpha-synuclein strains in Parkinson's disease.
(Springer, 2023)
Parkinson’s Disease (PD) is a neurodegenerative and progressive disorder characterised by intracytoplasmic inclusions ... |
Artículo
Targeting galectin-3 to counteract spike-phase uncoupling of fast-spiking interneurons to gamma oscillations in Alzheimer’s disease
(2023)
Background Alzheimer’s disease (AD) is a progressive multifaceted neurodegenerative disorder for which no disease-modifying ... |
Artículo
Microglial Caspase-3 is essential for modulating hippocampal neurogenesis.
(Elsevier, 2023)
Adult hippocampal neurogenesis (AHN) is a process involved in numerous neurodegenerative diseases. Many researchers have ... |
Artículo
FarmaEscape El Retorno: el empleo de una Escape Room como herramienta de aprendizaje en los estudios de la Facultad de Farmacia de la Universidad de Sevilla
(Real e Ilustre Colegio Oficial de Farmacéuticos, 2023)
Una Escape Room es un juego de escapismo en el que un grupo de personas están “atrapadas” en una sala cerrada, debiendo ... |
Tesis Doctoral
Caracterización del modelo condicional neuronal de caspasa 3 en condiciones fisiológicas y patológicas
(2022)
La caspasa 3 (casp 3) es una proteasa ampliamente conocida por su papel clave como mediadora en la apoptosis neuronal. En ... |
Tesis Doctoral
Papeles no apoptóticos de las caspasas en la neurogénesis hipocampal y el desarrollo embrionario de la microglía
(2022)
Debido al aumento de la esperanza de vida, existe cada vez una mayor prevalencia de enfermedades neurodegerativas que, ... |
| Artículo |
Artículo
Galectin-3, a rising star in modulating microglia activation under conditions of neurodegeneration
(Springer Nature, 2022)
The advent of high-throughput single-cell transcriptomic analysis of microglia has revealed different phenotypes that are ... |
Artículo
The Absence of Caspase-8 in the Dopaminergic System Leads to Mild Autism-like Behavior
(Frontiers Media S.A., 2022)
In the last decade, new non-apoptotic roles have been ascribed to apoptotic caspases. This family of proteins plays an ... |
Artículo
Selective deletion of Caspase-3 gene in the dopaminergic system exhibits autistic-like behaviour
(Elsevier, 2021)
Apoptotic caspases are thought to play critical roles in elimination of excessive and non-functional synapses and removal ... |
Artículo
The Other Side of SARS-CoV-2 Infection: Neurological Sequelae in Patients
(Frontiers Media S.A., 2021)
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has spread around the globe causing coronavirus disease ... |
Artículo
The HERC proteins and the nervous system
(Elsevier, 2021)
The HERC protein family is one of three subfamilies of Homologous to E6AP C-terminus (HECT) E3 ubiquitin ligases. Six HERC ... |
| Trabajo Fin de Grado |
Artículo
HERC1 Ubiquitin Ligase Is Required for Hippocampal Learning and Memory
(Frontiers Media, 2020)
Mutations in the human HERC1 E3 ubiquitin ligase protein develop intellectual disability. The tambaleante (tbl) mouse ... |
Artículo
The Ubiquitin Proteasome System in Neuromuscular Disorders: Moving Beyond Movement
(Multidisciplinary Digital Publishing Institute (MDPI), 2020)
Neuromuscular disorders (NMDs) affect 1 in 3000 people worldwide. There are more than 150 different types of NMDs, where ... |
Artículo
TET2 Regulates the Neuroinflammatory Response in Microglia
(Elsevier, 2019)
Epigenomic mechanisms regulate distinct aspects of the inflammatory response in immune cells. Despite the central role for ... |
Ponencia
El uso de una escape room como recurso docente en la Facultad de Farmacia
(Editorial Universitat Politècnica de València, 2019)
Las Escape Rooms son un tipo de recurso que está siendo utilizado por muchos educadores, propiciando elementos de colaboración ... |
Artículo
Reformulating Pro-Oxidant Microglia in Neurodegeneration
(MDPI, 2019)
In neurodegenerative diseases, microglia-mediated neuroinflammation and oxidative stress are central events. Recent ... |
Artículo
HERC1 Ubiquitin Ligase Is Required for Normal Axonal Myelination in the Peripheral Nervous System
(Springer, 2018)
A missense mutation in HERC1 provokes loss of cerebellar Purkinje cells, tremor, and unstable gait in tambaleante (tbl) ... |
Artículo
CSPα, a molecular co-chaperone essential for short and long-term synaptic maintenance
(Frontiers Media S.A., 2017)
Cysteine string protein a (CSPα) is a vesicle protein located in the presynaptic terminal of most synapses. CSPα is an ... |
Trabajo Fin de Grado
Implicación de la Caspasa 8 en el desarrollo embrionario
(2017)
Caspase8 “knock out” - Embryo development- Dual role La apoptosis o muerte celular inducida es un proceso de muerte ... |
Artículo
HERC 1 Ubiquitin Ligase Mutation Affects Neocortical, CA3 Hippocampal and Spinal Cord Projection Neurons: An Ultrastructural Study
(Frontiers Media, 2016)
The spontaneous mutation tambaleante is caused by the Gly483Glu substitution in the highly conserved N terminal RCC1-like ... |
Artículo
The HERC2 ubiquitin ligase is essential for embryonic development and regulates motor coordination
(Impact Journals, 2016)
A mutation in the HERC2 gene has been linked to a severe neurodevelopmental disorder with similarities to the Angelman ... |
Artículo
Morphological and functional remodelling of the neuromuscular junction by skeletal muscle PGC-1 alpha
(NATURE PUBLISHING GROUP, 2014)
The neuromuscular junction (NMJ) exhibits high morphological and functional plasticity. In the mature muscle, the relative ... |
Artículo
Fast motor axon loss in SMARD1 does not correspond to morphological and functional alterations of the NMJ
(Elsevier, 2013)
Spinal muscular atrophy with respiratory distress type 1 (SMARD1) is a childhood motoneuron disease caused by mutations ... |
Artículo
Active zones and the readily releasable pool of synaptic vesicles at the neuromuscular junction of the mouse
(SOC NEUROSCIENCE, 2011)
Synchronous neurotransmitter releaseis a highly regulated processthattakes place at specializations atthe presynapticmembrane ... |
Artículo
Synaptic defects in spinal muscular atrophy animal models
(Wiley, 2011)
Proximal spinal muscular atrophy, the most frequent genetic cause of childhood lethality, is caused by homozygous loss or ... |
Artículo
Altered Intracellular Ca2+ Homeostasis in Nerve Terminals of Severe Spinal Muscular Atrophy Mice
(SOC NEUROSCIENCE, 2010)
Low levels of survival motor neuron (SMN) protein result in spinal muscular atrophy (SMA), a severe genetic disease ... |
Artículo
Ciliary neurotrophic factor-induced sprouting preserves motor function in a mouse model of mild spinal muscular atrophy
(OXFORD UNIV PRESS, 2010)
Proximal spinal muscular atrophy (SMA) is caused by homozygous loss or mutation of the SMN1 gene on human chromosome 5. ... |
Tesis Doctoral
Monitorización de la función sináptica normal y patológica en modelos animales
(2009)
El objetivo principal de esta Tesis Doctoral ha sido el estudio de la transmisión sináptica en la unión neuromuscular. El ... |
Artículo
Cysteine string protein-α is essential for the high calciumsensitivity of exocytosis in a vertebrate synapse
(Wiley, 2008)
Cysteine string protein (CSPa) is a synaptic vesicle protein present in most central and peripheral nervous system ... |
Artículo
Monitoring synaptic function at the neuromuscular junction of a mouse expressing synaptopHluorin
(2007)
We monitored presynaptic exocytosis and vesicle recycling at neuromuscular junctions of transgenic mice expressing ... |
Artículo
Treatment with trkC agonist antibodies delays disease progression in neuromuscular degeneration (nmd) mice
(OXFORD UNIV PRESS, 2005)
Spinal muscular atrophy with respiratory distress type 1 (SMARD1) is a fatal autosomal recessive disorder seen in infants. ... |