Artículo
Cytotoxicity studies of a stilbene extract and its main components intended to be used as preservative in the wine industry
Autor/es | Medrano Padial, Concepción
Puerto Rodríguez, María Merchán Gragero, María del Mar Moreno Onorato, Francisco Javier Richard, Tristan Cantos Villar, Emma Pichardo Sánchez, Silvia |
Departamento | Universidad de Sevilla. Departamento de Nutrición y Bromatología, Toxicología y Medicina Legal Universidad de Sevilla. Departamento de Biología Celular |
Fecha de publicación | 2020 |
Fecha de depósito | 2021-12-21 |
Publicado en |
|
Resumen | The use of stilbenes has been proposed as an alternative to sulfur dioxide in wine. Provided the feasibility from a technological approach, the cytotoxicity of an extract from grapevine shoots containing a stilbene richness ... The use of stilbenes has been proposed as an alternative to sulfur dioxide in wine. Provided the feasibility from a technological approach, the cytotoxicity of an extract from grapevine shoots containing a stilbene richness of 99% (ST-99 extract) was assessed in the human cell lines HepG2 and Caco-2. In addition, the effects of the main stilbenes found in ST-99, trans-resveratrol and trans-ε-viniferin were studied, as well as its mixture. Similar cytotoxic effects were obtained in the exposures to trans-ε-viniferin, ST-99 and the mixture; however, trans-resveratrol alone exerted less toxicity. When HepG2 cells were exposed to trans-ε-viniferin, ST-99 and the mixture, the mean effective concentration (EC50) were 28.28 ± 2.15, 31.91 ± 1.55 and 29.47 ± 3.54 µg/mL, respectively. However, in the exposure to trans-resveratrol, the EC50 was higher 50 µg/mL. The morphological study evidenced damage at ultrastructural level in HepG2 cells, highlighting the inhibition of cell proliferation and the induction of apoptosis. The type of interaction produced by trans-ε-viniferin and trans-resveratrol mixtures was assessed by an isobologram analysis using the CalcuSyn software, evidencing an antagonist effect. These data comprise a starting point in the toxicological assessment; further studies are needed in this field to assure the safety of the extract ST-99. |
Agencias financiadoras | Ministerio de Economia, Industria y Competitividad (MINECO). España Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA) |
Identificador del proyecto | RTA2015-00005-C02-02
ANR-11-INBS-0010 |
Cita | Medrano Padial, C., Puerto Rodríguez, M., Merchán Gragero, M.d.M., Moreno Onorato, F.J., Richard, T., Cantos Villar, E. y Pichardo Sánchez, S. (2020). Cytotoxicity studies of a stilbene extract and its main components intended to be used as preservative in the wine industry. Food Research International, 137, 109738. |
Ficheros | Tamaño | Formato | Ver | Descripción |
---|---|---|---|---|
10.1016_j.foodres.2020.109738.pdf | 2.519Mb | [PDF] | Ver/ | Postprint |