Artículos (Biología Celular)
Recent Submissions
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Article
RNF212B E3 ligase is essential for crossover designation and maturation during male and female meiosis in the mouse
(National Academy of Sciences, 2024-06-12)Meiosis, a reductional cell division, relies on precise initiation, maturation, and resolution of crossovers (COs) during ...
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Dynamic modes of Notch transcription hubs conferring memory and stochastic activation revealed by live imaging the co-activator Mastermind
(eLife Sciences Publications Ltd., 2024-05-10)Developmental programming involves the accurate conversion of signalling levels and dynamics to transcriptional outputs. ...
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Real-life effectiveness of sofosbuvir/velpatasvir/voxilaprevir in hepatitis C patients previously treated with sofosbuvir/velpatasvir or glecaprevir/pibrentasvir
(Wiley, 2024-05-02)Background Sofosbuvir, velpatasvir and voxilaprevir (SOF/VEL/VOX) is the recommended rescue therapy for patients with ...
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Microglia mitochondrial complex I deficiency during development induces glial dysfunction and early lethality
(Nature, 2024-07-24)Primary mitochondrial diseases (PMDs) are associated with pediatric neurological disorders and are traditionally related ...
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Changes in the expression of inflammatory genes induced by chronic exercise in the adipose tissue: Differences by sex
(MDPI, 2024)The impact of obesity on adipose tissue function is well acknowledged, but the role of physical exercise in regulating ...
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Protein sorting upon exit from the endoplasmic reticulum dominates Golgi biogenesis in budding yeast
(Willey, 2023-02-24)Cells sense and control the number and quality of their organelles, but the underlying mechanisms of this regulation are ...
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Sacha Inchi (Plukenetia volubilis L.) Protein Hydrolysate as a New Ingredient of Functional Foods
(MDPI, 2024)Sacha inchi (Plukenetia volubilis L.) is an under-exploited crop with great potential due to its nutritional and medicinal ...
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UBE2D3 Facilitates NHEJ by Orchestrating ATM Signalling through Multi-level Control of RNF168
(Springer Nature, 2024)Maintenance of genome integrity requires tight control of DNA damage response (DDR) signalling and repair, with phosphorylation ...
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Rewiring of the epigenome and chromatin architecture by exogenously induced retinoic acid signaling during zebrafish embryonic development
(Oxford University Press, 2024-04-24)Retinoic acid (RA) is the ligand of RA receptors (RARs), transcription factors that bind to RA response elements. RA ...
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Physical interactions between specifically regulated subpopulations of the MCM and RNR complexes prevent genetic instability
(Public Library of Science, 2024-05-22)The helicase MCM and the ribonucleotide reductase RNR are the complexes that provide the substrates (ssDNA templates and ...
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Roles of Extracellular Vesicles Associated Non-coding RNAs in Diabetes Mellitus
(Frontiers Media SA, 2022)Extracellular vesicles (EVs), especially exosomes (50 to 150 nm), have been shown to play important roles in a wide range ...
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Physical Forces and Transient Nuclear Envelope Rupture During Metastasis: The Key for Success?
(Multidisciplinary Digital Publishing Institute (MDPI), 2022)During metastasis, invading tumor cells and circulating tumor cells (CTC) face multiple mechanical challenges during ...
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NR5A2/LRH-1 Regulates the PTGS2-PGE2-PTGER1 Pathway Contributing to Pancreatic Islet Survival and Function
(Elsevier, 2022)LRH-1/NR5A2 is implicated in islet morphogenesis postnatally, and its activation using the agonist BL001 protects islets ...
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The PTGS2/COX2-PGE2 Signaling Cascade in Inflammation: Pro or Anti? A Case Study with Type 1 Diabetes Mellitus
(Ivyspring International Publisher, 2023)Prostaglandins are lipid mediators involved in physiological processes, such as constriction or dilation of blood vessels, ...
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Metabolic Reprogramming by Acly Inhibition Using SB-204990 Alters Glucoregulation and Modulates Molecular Mechanisms Associated with Aging
(Springer Nature, 2023)ATP-citrate lyase is a central integrator of cellular metabolism in the interface of protein, carbohydrate, and lipid ...
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Article
Enzyme-Responsive Zr-Based Metal-Organic Frameworks for Controlled Drug Delivery: Taking Advantage of Clickable PEG-Phosphate Ligands
(American Chemical Society, 2023)We report for the first time the controlled drug release from a nanoscale Zr-based metal-organic framework (MOF), UiO-66, ...
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Article
dsRNAi-mediated silencing of PIAS2beta specifically kills anaplastic carcinomas by mitotic catastrophe
(Springer Nature, 2024-05-14)The E3 SUMO ligase PIAS2 is expressed at high levels in differentiated papillary thyroid carcinomas but at low levels in ...
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Article
BRCA1/BARD1 ubiquitinates PCNA in unperturbed conditions to promote continuous DNA synthesis
(Nature Research, 2024-05-20)Deficiencies in the BRCA1 tumor suppressor gene are the main cause of hereditary breast and ovarian cancer. BRCA1 is ...
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Article
RENEB Inter-Laboratory Comparison 2021: Inter-Assay Comparison of Eight Dosimetry Assays
(Radiation Research Society, 2023)Tools for radiation exposure reconstruction are required to support the medical management of radiation victims in ...
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Article
SUMO-activated Target Traps (SATTs) Enable the Identification of a Comprehensive E3-specific SUMO Proteome
(American Association for the Advancement of Science, 2023)Ubiquitin and ubiquitin-like conjugation cascades consist of dedicated E1, E2, and E3 enzymes with E3s providing substrate ...