Recent Submissions

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    Response to "High CD44 expression is not a prognosis marker in patients with high-risk neuroblastoma"  [Article]

    Vega Moreno, Francisco Manuel; Colmenero Repiso, Ana; Gómez Muñoz, María A.; Rodríguez Prieto, Ismael; Aguilar Morante, Diana; Ramírez, Gema; Márquez, Catalina; Cabello, Rosa; Pardal, Ricardo (Elsevier, 2020)
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    Effect of DNA repair deficiencies on the cytotoxicity of resveratrol  [Article]

    López Lázaro, Miguel; Burgos Morón, Estefanía; Calderón Montaño, José Manuel; Orta Vázquez, Manuel Luis; Mateos Cordero, Santiago (2015)
    Numerous preclinical studies have shown that the naturally-occurring polyphenol resveratrol may produce health-beneficial effects in a variety of disorders, including cancer, diabetes, Alzheimer, and cardiovascular ...
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    Hypoxia in the Initiation and Progression of Neuroblastoma Tumours  [Article]

    Huertas Castaño, Carlos; Gómez Muñoz, María Ángeles; Pardal Redondo, Ricardo; Vega Moreno, Francisco Manuel (MDPI, 2019)
    Neuroblastoma is the most frequent extracranial solid tumour in children, causing 10% of all paediatric oncology deaths. It arises in the embryonic neural crest due to an uncontrolled behaviour of sympathetic nervous system ...
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    Neurotoxic assessment of Microcystin-LR, cylindrospermopsin andtheir combination on the human neuroblastoma SH-SY5Y cell line  [Article]

    Hinojosa Hidalgo, María Gracia; Prieto Ortega, Ana Isabel; Gutiérrez Praena, Daniel; Moreno Onorato, Francisco Javier; Cameán Fernández, Ana María; Jos Gallego, Ángeles Mencía (Elsevier, 2019-02-27)
    Microcystin-LR (MC-LR) and Cylindrospermopsin (CYN) are produced by cyanobacteria. Although being considered as a hepatotoxin and a cytotoxin, respectively, different studies have revealed neurotoxic properties for both ...
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    Nutraceutical Extract from Dulse (Palmaria palmata L.) Inhibits Primary Human Neutrophil Activation  [Article]

    Millán Linares, María del Carmen; Martín Rubio, María Esther; Rodríguez Martín, Noelia María; Toscano Sánchez, Mª del Rocío; Claro Cala, Carmen María; Bermúdez Pulgarín, Beatriz; Pedroche Jiménez, Justo Javier; Millán Rodríguez, Francisco; Montserrat de la Paz, Sergio (MDPI, 2019)
    Palmaria palmata L. (Palmariaceae), commonly known as "dulse", is a red alga that grows on the northern coasts of the Atlantic and Pacific oceans, and is widely used as source of fiber and protein. Dulse is reported to ...
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    CD44-high neural crest stem-like cells are associated with tumour aggressiveness and poor survival in neuroblastoma tumours  [Article]

    Vega Moreno, Francisco Manuel; Colmenero Repiso, Ana; Gómez Muñoz, María A.; Rodríguez Prieto, Ismael; Aguilar Morante, Diana; Pardal Redondo, Ricardo (Elsevier, 2019)
    BACKGROUND: Neuroblastoma is a paediatric tumour originated from sympathoadrenal precursors and characterized by its heterogeneity and poor outcome in advanced stages. Intra-tumoral cellular heterogeneity has emerged as ...
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    Endoplasmic Reticulum Export of GPI-Anchored Proteins  [Article]

    López Martín, Sergio; Rodríguez Gallardo, Sofía; Sabido Bozo, Susana; Muñiz Guinea, Manuel (MDPI, 2019)
    Protein export from the endoplasmic reticulum (ER) is an essential process in all eukaryotes driven by the cytosolic coat complex COPII, which forms vesicles at ER exit sites for transport of correctly assembled secretory ...
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    Long-Term Evaluation of Mesophilic Semi-Continuous Anaerobic Digestion of Olive Mill Solid Waste Pretreated with Steam-Explosion  [Article]

    Serrano Moral, Antonio; González Fermoso, Fernando; Alonso Fariñas, Bernabé; Rodríguez Gutiérrez, Guillermo; López Martín, Sergio; Fernández Bolaños, Juan; Borja Padilla, Rafael (MDPI, 2019)
    Steam-explosion is a promising technology for recovering phenolic compounds from olive mill solid waste (OMSW) due to its high impact on the structure of the fibre. Moreover, the recovery of the phenols, which are ...
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    Neuroprotective Effects of Diets Containing Olive Oil and DHA/EPA in a Mouse Model of Cerebral Ischemia  [Article]

    Gonzalo Gobernado, Rafael; Ayuso, María Irene; Sansone, Loredana; Bernal Jiménez, Juan José; Ramos Herrero, Víctor Darío; Sánchez García, Enrique; Ramos, Teresa L.; Abia González, María del Rocío; García Muriana, Francisco José; Bermúdez Pulgarín, Beatriz; Montaner, Joan (MDPI, 2019)
    Stroke is one of the leading causes of death worldwide and while there is increasing evidence that a Mediterranean diet might decrease the risk of a stroke, the effects of dietary fat composition on stroke outcomes have ...
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    Sinorhizobium fredii HH103 RirA is required for oxidative stress resistance and efficient symbiosis with Soybean  [Article]

    Crespo Rivas, Juan Carlos; Navarro Gómez, Pilar; Alias Villegas, Cynthia Victoria; Moreno Onorato, Francisco Javier; Cubo Sánchez, María Teresa; Vinardell González, José María; Ruiz Sainz, José Enrique; Acosta Jurado, Sebastián (MDPI, 2019-02-12)
    Members of Rhizobiaceae contain a homologue of the iron-responsive regulatory protein RirA. In different bacteria, RirA acts as a repressor of iron uptake systems under iron-replete conditions and contributes to ameliorate ...
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    Sinorhizobium fredii Strains HH103 and NGR234 Form Nitrogen Fixing Nodules With Diverse Wild Soybeans (Glycine soja) From Central China but Are Ineffective on Northern China Accessions  [Article]

    Temprano Vera, Francisco Jesús; Rodríguez Navarro, Dulce Nombre; Acosta Jurado, Sebastián; Navarro Gómez, Pilar; Buendía Clavería, Ana María; Moreno Onorato, Francisco Javier; López Baena, Francisco Javier; Ruiz Sainz, José Enrique; Vinardell González, José María (Frontiers Media, 2018)
    Sinorhizobium fredii indigenous populations are prevalent in provinces of Central China whereas Bradyrhizobium species (Bradyrhizobium japonicum, B. diazoefficiens, B. elkanii, and others) are more abundant in northern and ...
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    The Cockayne syndrome protein B is involved in the repair of 5-AZA-2′-deoxycytidine-induced DNA lesions  [Article]

    Burgos Morón, Estefanía; Calderón Montaño, José Manuel; Pastor Carrillo, Nuria María; Ruiz Castizo, Ángel; Domínguez García, Inmaculada; López Lázaro, Miguel; Mateos Cordero, Santiago; Orta Vázquez, Manuel Luis (Impact Journals, 2018)
    The Cockayne Syndrome Protein B (CSB) plays an essential role in Transcription-Coupled Nucleotide Excision Repair (TC-NER) by recruiting repair proteins once transcription is blocked with a DNA lesion. In fact, CSB-deficient ...
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    Author Correction: Scutoids are a geometrical solution to three-dimensional packing of epithelia  [Article]

    Gómez Gálvez, Pedro; Vicente Munuera, Pablo; Tagua Jáñez, Antonio Jesús; Forja, Cristina; Castro Rodríguez, Ana María; Grima Ruiz, Clara Isabel; Bermúdez Gallardo, Marina; Márquez Pérez, Alberto; Escudero Cuadrado, Luis María (Nature Research, 2018)
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    Nintedanib decreases muscle fibrosis and improves muscle function in a murine model of dystrophinopathy  [Article]

    Piñol Jurado, Patricia; Suárez Calvet, Xavier; Fernández Simón, Esther; Gómez Gálvez, Pedro; Escudero Cuadrado, Luis María; Díaz Manera, Jordi (Nature Publishing Group, 2018)
    Duchenne muscle dystrophy (DMD) is a genetic disorder characterized by progressive skeletal muscle weakness. Dystrophin deficiency induces instability of the sarcolemma during muscle contraction that leads to muscle necrosis ...
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    Scutoids are a geometrical solution to three-dimensional packing of epithelia  [Article]

    Gómez Gálvez, Pedro; Vicente Munuera, Pablo; Tagua Jáñez, Antonio; Forja Barbosa, Cristina; Castro Rodríguez, Ana María; Letrán, Marta; Grima Ruiz, Clara Isabel; Bermúdez Gallardo, Marina; Serrano Pérez-Higueras, Óscar; Márquez Pérez, Alberto; Escudero Cuadrado, Luis María (Nature Publishing Group, 2018)
    As animals develop, tissue bending contributes to shape the organs into complex three-dimensional structures. However, the architecture and packing of curved epithelia remains largely unknown. Here we show by means of ...
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    Sensing Cell-Culture Assays with Low-Cost Circuitry  [Article]

    Pérez García, Pablo; Huertas Sánchez, Gloria; Maldonado Jacobi, Andrés; Martín Rubio, María Esther; Serrano Viseas, Juan Alfonso; Olmo Fernández, Alberto; Daza Navarro, María Paula; Yúfera García, Alberto (Nature Publishing Group, 2018)
    An alternative approach for cell-culture end-point protocols is proposed herein. This new technique is suitable for real-time remote sensing. It is based on Electrical Cell-substrate Impedance Spectroscopy (ECIS) and employs ...
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    Epithelial organisation revealed by a network of cellular contacts  [Article]

    Escudero Cuadrado, Luis María; Costa, Luciano da F.; Kicheva, Anna; Briscoe, James; Freeman, Matthew; Babu, Madan (Nature Publishing Group, 2011)
    The emergence of differences in the arrangement of cells is the first step towards the establishment of many organs. Understanding this process is limited by the lack of systematic characterization of epithelial organisation. ...
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    Osh proteins regulate COPII-mediated vesicular transport of ceramide from the endoplasmic reticulum in budding yeast  [Article]

    Kajiwara, Kentaro; Ikeda, Atsuko; Aguilera Romero, María Auxiliadora; Castillon, Guillaume Alain; Muñiz Guinea, Manuel; Funato, Kouichi (Company of Biologists Ltd, 2014)
    Lipids synthesized at the endoplasmic reticulum (ER) are delivered to the Golgi by vesicular and non-vesicular pathways. ER-to-Golgi transport is crucial for maintaining the different membrane lipid composition and identities ...
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    Hydroxyurea-Stalled Replication Forks Become Progressively Inactivated and Require Two Different RAD51-Mediated Pathways for Restart and Repair  [Article]

    Petermann, Eva; Orta Vázquez, Manuel Luis; Issaeva, Natalia; Schultz, Niklas; Helleday, Thomas (Elsevier, 2010)
    Faithful DNA replication is essential to all life. Hydroxyurea (HU) depletes the cells of dNTPs, which initially results in stalled replication forks that, after prolonged treatment, collapse into DSBs. Here, we report ...
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    5-Aza-2'-deoxycytidine causes replication lesions that require Fanconi anemia-dependent homologous recombination for repair  [Article]

    Orta Vázquez, Manuel Luis; Calderón Montaño, José Manuel; Domínguez García, Inmaculada; Pastor Carrillo, Nuria María; Burgos Morón, Estefanía; López Lázaro, Miguel; Cortés, Felipe; Mateos Cordero, Santiago; Helleday, Thomas (Oxford University Press, 2013)
    5-Aza-2'-deoxycytidine (5-azadC) is a DNA methyltransferase (DNMT) inhibitor increasingly used in treatments of hematological diseases and works by being incorporated into DNA and trapping DNMT. It is unclear what DNA ...

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