Buscar
Mostrando ítems 1-10 de 12
Artículo
miR-7 Modulates hESC Differentiation into Insulin-Producing Beta-like Cells and Contributes to Cell Maturation
(The American Society of Gene and Cell Therapy, 2018-09-07)
Human pluripotent stem cells retain the extraordinary capacity to differentiate into pancreatic beta cells. For this particular lineage, more effort is still required to stress the importance of developing an efficient, ...
Artículo
LRH-1 agonism favours an immune-islet dialogue which protects against diabetes mellitus
(Nature Publishing Group, 2018-04-16)
Type 1 diabetes mellitus (T1DM) is due to the selective destruction of islet beta cells by immune cells. Current therapies focused on repressing the immune attack or stimulating beta cell regeneration still have limited ...
Artículo
Oestrogen receptor β mediates the actions of bisphenol-A on ion channel expression in mouse pancreatic beta cells
(Springer Nature, 2019-09)
Aims/hypothesis: Bisphenol-A (BPA) is a widespread endocrine-disrupting chemical that has been associated with type 2 diabetes development. Low doses of BPA modify pancreatic beta cell function and induce insulin resistance; ...
Artículo
Gene-Diet Interactions in Type 2 Diabetes: The Chicken and Egg Debate
(MDPI, 2017)
Consistent evidence from both experimental and human studies indicates that Type 2 diabetes mellitus (T2DM) is a complex disease resulting from the interaction of genetic, epigenetic, environmental, and lifestyle factors. ...
Artículo
EGF-induced adipose tissue mesothelial cells undergo functional vascular smooth muscle differentiation
(Nature Publishing Group, 2014)
Recent studies suggested that the post-natal mesothelium retain differentiative potential of the embryonic mesothelium, which generates fibroblasts and vascular smooth muscle cells (VSMCs), in developing coelomic organs ...
Artículo
Human Mesenchymal Stem Cells Prevent Neurological Complications of Radiotherapy
(Frontiers Media S.A., 2019-05-16)
Radiotherapy is a highly effective tool for the treatment of brain cancer. However, radiation also causes detrimental effects in the healthy tissue, leading to neurocognitive sequelae that compromise the quality of life ...
Artículo
Impact of transient down-regulation of DREAM in human embryonic stem cell pluripotency: The role of DREAM in the maintenance of hESCs
(Elsevier, 2016)
Little is knownabout the functions of downstreamregulatory element antagonist modulator (DREAM) inembryonic stem cells (ESCs). However, DREAM interacts with cAMP response element-binding protein (CREB) in a Ca2+-dependent ...
Artículo
Zn2+ chelation by serum albumin improves hexameric Zn2+ -insulin dissociation into monomers after exocytosis
(Public Library of Science, 2017)
β-cells release hexameric Zn2+-insulin into the extracellular space, but monomeric Zn2+-free insulin appears to be the only biologically active form. The mechanisms implicated in dissociation of the hexamer remain unclear, ...
Artículo
Artículo
Therapeutic Potential of Mesenchymal Stem Cells for Cancer Therapy
(Frontiers Media S.A., 2020)
Mesenchymal stem cells (MSCs) are among the most frequently used cell type for regenerative medicine. A large number of studies have shown the beneficial effects of MSC-based therapies to treat different pathologies, ...