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Artículo
LRH-1 agonism favours an immune-islet dialogue which protects against diabetes mellitus
Autor/es | Cobo Vuilleumier, Nadia
Lorenzo, Petra I. García Rodríguez, Noelia Herrera Gómez, Irene G. Fuente Martín, Esther López Noriega, Livia Mellado Gil, José Manuel Romero Zerbo, Silvana Y. Lachaud, Christian Hmadcha, Abdelkrim Sánchez Palazón, Luis Martín Montalvo, Alejandro Soria Escoms, Bernat Gauthier, Benoit R. |
Departamento | Centro Andaluz de Biología Molecular y Medicina Regenerativa (CABIMER) |
Fecha de publicación | 2018-04-16 |
Fecha de depósito | 2018-05-28 |
Publicado en |
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Resumen | Type 1 diabetes mellitus (T1DM) is due to the selective destruction of islet beta cells by immune cells. Current therapies focused on repressing the immune attack or stimulating beta cell regeneration still have limited ... Type 1 diabetes mellitus (T1DM) is due to the selective destruction of islet beta cells by immune cells. Current therapies focused on repressing the immune attack or stimulating beta cell regeneration still have limited clinical efficacy. Therefore, it is timely to identify innovative targets to dampen the immune process, while promoting beta cell survival and function. Liver receptor homologue-1 (LRH-1) is a nuclear receptor that represses inflammation in digestive organs, and protects pancreatic islets against apoptosis. Here, we show that BL001, a small LRH-1 agonist, impedes hyperglycemia progression and the immune-dependent inflammation of pancreas in murine models of T1DM, and beta cell apoptosis in islets of type 2 diabetic patients, while increasing beta cell mass and insulin secretion. Thus, we suggest that LRH-1 agonism favors a dialogue between immune and islet cells, which could be druggable to protect against diabetes mellitus. |
Identificador del proyecto | PI-0727-2010
P10CTS6505 P10.CTS.6359 PI10/00871 PI13/00593 BFU2017-83588-P PI14/01015 RD12/0019/0028 RD16/0011/0034 PI16/00259 GRK-1789 SCHI-505/ 6-1 CP14/ 00105 17-2013-372 3-RSC-2016-162-I-X |
Cita | Cobo Vuilleumier, N., Lorenzo, P.I., García Rodríguez, N., Herrera Gómez, I.G., Fuente-Martín, E., López-Noriega, L.,...,Gauthier, B.R. (2018). LRH-1 agonism favours an immune-islet dialogue which protects against diabetes mellitus. Nature Communications, 9 (1), 1488-1-1488-15. |
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LRH-1 agonism favours.pdf | 5.636Mb | [PDF] | Ver/ | |