Artículo
Human Mesenchymal Stem Cells Prevent Neurological Complications of Radiotherapy
Autor/es | Soria Escoms, Bernat
Martín Montalvo, Alejandro Aguilera García, Yolanda Mellado, Nuria López Beas, Javier Herrera-Herrera, Isabel López, Escarlata Barcia, Juan A. Álvarez Dolado, Manuel Hmadcha, Abdelkrim Capilla González, Vivian |
Departamento | Centro Andaluz de Biología Molecular y Medicina Regenerativa (CABIMER) |
Fecha de publicación | 2019-05-16 |
Fecha de depósito | 2019-09-18 |
Publicado en |
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Resumen | Radiotherapy is a highly effective tool for the treatment of brain cancer. However, radiation also causes detrimental effects in the healthy tissue, leading to neurocognitive sequelae that compromise the quality of life ... Radiotherapy is a highly effective tool for the treatment of brain cancer. However, radiation also causes detrimental effects in the healthy tissue, leading to neurocognitive sequelae that compromise the quality of life of brain cancer patients. Despite the recognition of this serious complication, no satisfactory solutions exist at present. Here we investigated the effects of intranasal administration of human mesenchymal stem cells (hMSCs) as a neuroprotective strategy for cranial radiation in mice. Our results demonstrated that intranasally delivered hMSCs promote radiation-induced brain injury repair, improving neurological function. This intervention confers protection against inflammation, oxidative stress, and neuronal loss. hMSC administration reduces persistent activation of damage-induced c-AMP response element-binding signaling in irradiated brains. Furthermore, hMSC treatment did not compromise the survival of glioma-bearing mice. Our findings encourage the therapeutic use of hMSCs as a non-invasive approach to prevent neurological complications of radiotherapy, improving the quality of life of brain tumor patients. |
Identificador del proyecto | PI-0109-2014
PI-0272-2017 RD16/0011/0034 PI17/02104 PI18/01590 PI15/00134 PI16/00259 2018-000237 CP14/00105 CD16/00118 |
Cita | Soria Escoms, B., Martín Montalvo, A., Aguilera García, Y., Mellado, N., López Beas, J., Herrera-Herrera, I.,...,Capilla-González, V. (2019). Human Mesenchymal Stem Cells Prevent Neurological Complications of Radiotherapy. Frontiers in Cellular Neuroscience, 13, 204-1-204-14. |
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