Artículo
Impact of transient down-regulation of DREAM in human embryonic stem cell pluripotency: The role of DREAM in the maintenance of hESCs
Autor/es | Fontán Lozano, Ángela del Carmen
Capilla González, Vivian Aguilera, Yolanda Mellado, Nuria Carrión Rodríguez, Ángel Manuel Soria Escoms, Bernat Hmadcha, Abdelkrim |
Departamento | Universidad de Sevilla. Departamento de Fisiología |
Fecha de publicación | 2016 |
Fecha de depósito | 2019-01-22 |
Publicado en |
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Resumen | Little is knownabout the functions of downstreamregulatory element antagonist modulator (DREAM) inembryonic
stem cells (ESCs). However, DREAM interacts with cAMP response element-binding protein (CREB) in a
Ca2+-dependent ... Little is knownabout the functions of downstreamregulatory element antagonist modulator (DREAM) inembryonic stem cells (ESCs). However, DREAM interacts with cAMP response element-binding protein (CREB) in a Ca2+-dependent manner, preventing CREB binding protein (CBP) recruitment. Furthermore, CREB and CBP are involved in maintaining ESC self-renewal and pluripotency. However, a previous knockout study revealed the protective function of DREAMdepletion in brain aging degeneration and that aging is accompanied by a progressive decline in stem cells (SCs) function. Interestingly, we found that DREAM is expressed in different cell types, including human ESCs (hESCs), human adipose-derived stromal cells (hASCs), human bone marrow-derived stromal cells (hBMSCs), and human newborn foreskin fibroblasts (hFFs), and that transitory inhibition of DREAMin hESCs reduces their pluripotency, increasing differentiation.We stipulate that these changes are partly mediated by increased CREB transcriptional activity. Overall, our data indicates that DREAMacts in the regulation of hESC pluripotency and could be a target to promote or prevent differentiation in embryonic cells. |
Identificador del proyecto | CTS-6505
INP-2011- 1615-900000 P10-CVI-6095 RD12/0019/0028 PI10/00964 PI14/01015 |
Cita | Fontán Lozano, Á.d.C., Capilla González, V., Aguilera, Y., Mellado, N., Carrión Rodríguez, Á.M., Soria Escoms, B. y Hmadcha, A. (2016). Impact of transient down-regulation of DREAM in human embryonic stem cell pluripotency: The role of DREAM in the maintenance of hESCs. Stem Cell Research, 16 (3), 568-578. |
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