Artículo
Histone H3E73Q and H4E53A mutations cause recombinogenic DNA damage
Autor/es | Ortega Moreno, Pedro
García Pichardo, Desiré San Martín Alonso, Marta García Rondón, Ana Gómez González, Belén Aguilera López, Andrés |
Departamento | Universidad de Sevilla. Departamento de Genética |
Fecha de publicación | 2020 |
Fecha de depósito | 2020-09-28 |
Publicado en |
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Resumen | The stability and function of eukaryotic genomes is closely linked to histones and to chromatin structure. The state of the chromatin not only affects the probability of DNA to undergo damage but also DNA repair. DNA damage ... The stability and function of eukaryotic genomes is closely linked to histones and to chromatin structure. The state of the chromatin not only affects the probability of DNA to undergo damage but also DNA repair. DNA damage can result in genetic alterations and subsequent development of cancer and other genetic diseases. Here, we identified two mutations in conserved residues of histone H3 and histone H4 (H3E73Q and H4E53A) that increase recombinogenic DNA damage. Our results suggest that the accumulation of DNA damage in these histone mutants is largely independent on transcription and might arise as a consequence of problems occurring during DNA replication. This study uncovers the relevance of H3E73 and H4E53 residues in the protection of genome integrity. |
Identificador del proyecto | ERC2014 AdG669898 TARLOOP
BFU2016-75058-P |
Cita | Ortega Moreno, P., García Pichardo, D., San Martín Alonso, M., García Rondón, A., Gómez González, B.M. y Aguilera López, A. (2020). Histone H3E73Q and H4E53A mutations cause recombinogenic DNA damage. Microbial Cell, 7 (7), 190-198. |
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