Artículo
Defining the Emergence of New Immunotherapy Approaches in Breast Cancer: Role of Myeloid-Derived Suppressor Cells
Autor/es | Sánchez León, María Luisa
Jiménez Cortegana, Carlos Silva Romeiro, Silvia Garnacho Montero, Carmen Cruz Merino, Luis de la García-Domínguez, Daniel J. Hontecillas-Prieto, Lourdes Sánchez Margalet, Víctor |
Departamento | Universidad de Sevilla. Departamento de Medicina Universidad de Sevilla. Departamento de Bioquímica Médica y Biología Molecular e Inmunología |
Fecha de publicación | 2023 |
Fecha de depósito | 2024-03-01 |
Publicado en |
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Resumen | Breast cancer (BC) continues to be the most diagnosed tumor in women and a very
heterogeneous disease both inter- and intratumoral, mainly given by the variety of molecular profiles
with different biological and clinical ... Breast cancer (BC) continues to be the most diagnosed tumor in women and a very heterogeneous disease both inter- and intratumoral, mainly given by the variety of molecular profiles with different biological and clinical characteristics. Despite the advancements in early detection and therapeutic strategies, the survival rate is low in patients who develop metastatic disease. Therefore, it is mandatory to explore new approaches to achieve better responses. In this regard, immunotherapy arose as a promising alternative to conventional treatments due to its ability to modulate the immune system, which may play a dual role in this disease since the relationship between the immune system and BC cells depends on several factors: the tumor histology and size, as well as the involvement of lymph nodes, immune cells, and molecules that are part of the tumor microenvironment. Particularly, myeloid-derived suppressor cell (MDSC) expansion is one of the major immunosuppressive mechanisms used by breast tumors since it has been associated with worse clinical stage, metastatic burden, and poor efficacy of immunotherapies. This review focuses on the new immunotherapies in BC in the last five years. Additionally, the role of MDSC as a therapeutic target in breast cancer will be described. |
Cita | Sánchez León, M.L., Jiménez Cortegana, C., Silva Romeiro, S., Garnacho Montero, C., Cruz Merino, L.d.l., García-Domínguez, D.J.,...,Sánchez Margalet, V. (2023). Defining the Emergence of New Immunotherapy Approaches in Breast Cancer: Role of Myeloid-Derived Suppressor Cells. International Journal of Molecular Sciences, 24 (6), 5208. https://doi.org/10.3390/ijms24065208. |
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