dc.creator | Sánchez León, María Luisa | es |
dc.creator | Jiménez Cortegana, Carlos | es |
dc.creator | Silva Romeiro, Silvia | es |
dc.creator | Garnacho Montero, Carmen | es |
dc.creator | Cruz Merino, Luis de la | es |
dc.creator | García-Domínguez, Daniel J. | es |
dc.creator | Hontecillas-Prieto, Lourdes | es |
dc.creator | Sánchez Margalet, Víctor | es |
dc.date.accessioned | 2024-03-01T15:59:53Z | |
dc.date.available | 2024-03-01T15:59:53Z | |
dc.date.issued | 2023 | |
dc.identifier.citation | Sánchez León, M.L., Jiménez Cortegana, C., Silva Romeiro, S., Garnacho Montero, C., Cruz Merino, L.d.l., García-Domínguez, D.J.,...,Sánchez Margalet, V. (2023). Defining the Emergence of New Immunotherapy Approaches in Breast Cancer: Role of Myeloid-Derived Suppressor Cells. International Journal of Molecular Sciences, 24 (6), 5208. https://doi.org/10.3390/ijms24065208. | |
dc.identifier.issn | 1422-0067 | es |
dc.identifier.uri | https://hdl.handle.net/11441/155761 | |
dc.description.abstract | Breast cancer (BC) continues to be the most diagnosed tumor in women and a very
heterogeneous disease both inter- and intratumoral, mainly given by the variety of molecular profiles
with different biological and clinical characteristics. Despite the advancements in early detection
and therapeutic strategies, the survival rate is low in patients who develop metastatic disease.
Therefore, it is mandatory to explore new approaches to achieve better responses. In this regard,
immunotherapy arose as a promising alternative to conventional treatments due to its ability to
modulate the immune system, which may play a dual role in this disease since the relationship
between the immune system and BC cells depends on several factors: the tumor histology and size,
as well as the involvement of lymph nodes, immune cells, and molecules that are part of the tumor
microenvironment. Particularly, myeloid-derived suppressor cell (MDSC) expansion is one of the
major immunosuppressive mechanisms used by breast tumors since it has been associated with
worse clinical stage, metastatic burden, and poor efficacy of immunotherapies. This review focuses on
the new immunotherapies in BC in the last five years. Additionally, the role of MDSC as a therapeutic
target in breast cancer will be described. | es |
dc.format | application/pdf | es |
dc.format.extent | 28 p. | es |
dc.language.iso | eng | es |
dc.publisher | Mdpi Ag | es |
dc.relation.ispartof | International Journal of Molecular Sciences, 24 (6), 5208. | |
dc.rights | Atribución 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.subject | Breast cancer | es |
dc.subject | Tumor microenvironment | es |
dc.subject | Myeloid-derived suppressor cells | es |
dc.subject | Immunotherapy | es |
dc.title | Defining the Emergence of New Immunotherapy Approaches in Breast Cancer: Role of Myeloid-Derived Suppressor Cells | es |
dc.type | info:eu-repo/semantics/article | es |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Medicina | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Bioquímica Médica y Biología Molecular e Inmunología | es |
dc.relation.publisherversion | https://www.mdpi.com/1422-0067/24/6/5208 | es |
dc.identifier.doi | 10.3390/ijms24065208 | es |
dc.journaltitle | International Journal of Molecular Sciences | es |
dc.publication.volumen | 24 | es |
dc.publication.issue | 6 | es |
dc.publication.initialPage | 5208 | es |