Listar Artículos (Farmacología) por agencia financiadora "Junta de Andalucía"
Mostrando ítems 1-20 de 36
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5-Aza-2'-deoxycytidine causes replication lesions that require Fanconi anemia-dependent homologous recombination for repair
(Oxford University Press, 2013)5-Aza-2'-deoxycytidine (5-azadC) is a DNA methyltransferase (DNMT) inhibitor increasingly used in treatments of hematological ...
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A New Peracetylated Oleuropein Derivative Ameliorates Joint Inflammation and Destruction in a Murine Collagen-Induced Arthritis Model via Activation of the Nrf-2/Ho-1 Antioxidant Pathway and Suppression of MAPKs and NF-κB Activation
(MDPI, 2021-01)Oleuropein (OL), an olive tree secoiridoid and its peracetylated derivate (Per-OL) haveexhibited several beneficial effects ...
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Age-related changes in melatonin synthesis in rat extrapineal tissues
(Elsevier, 2009-05)In the search of new therapeutic targets improving the quality of life of elderly, melatonin, “the chemical expression of ...
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An Efficient and Practical Method for the Enantioselective Synthesis of Tertiary Trifluoromethyl Carbinols
(Wiley Online Library, 2018-03)An efficient sulfinamide/olefin based chiral ligand, MetSulfolefin, has been developed for the enantioselective rhodium-catalysed ...
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Anticancer Activities of Meroterpenoids Isolated from the Brown Alga Cystoseira usneoides against the Human Colon Cancer Cells HT-29
(MDPI, 2020)Colorectal cancer (CRC) is one of the most common types of cancers and a leading cause of cancer death worldwide. The ...
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Artificial Diets Based on Selective Amino Acid Restriction versus Capecitabine in Mice with Metastatic Colon Cancer
(MDPI, 2022)New therapies are needed to improve the low survival rates of patients with metastatic colon cancer. Evidence suggests ...
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Artificial Diets with Altered Levels of Sulfur Amino Acids Induce Anticancer Activity in Mice with Metastatic Colon Cancer, Ovarian Cancer and Renal Cell Carcinoma
(Multidisciplinary Digital Publishing Institute (MDPI), 2023)Sulfur-containing amino acids methionine (Met), cysteine (Cys) and taurine (Tau) are common dietary constituents with ...
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Artificial Diets with Selective Restriction of Amino Acids and Very Low Levels of Lipids Induce Anticancer Activity in Mice with Metastatic Triple-Negative Breast Cancer
(Multidisciplinary Digital Publishing Institute (MDPI), 2023)Current treatments for patients with metastatic triple negative breast cancer (TNBC) are generally ineffective. This ...
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Daidzein and Equol: Ex Vivo and In Silico Approaches Targeting COX-2, iNOS, and the Canonical Inflammasome Signaling Pathway
(Multidisciplinary Digital Publishing Institute (MDPI), 2024-05-16)Background: The inflammasome is a cytosolic multiprotein complex associated with multiple autoimmune diseases. Phytochemical ...
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Design, synthesis and biological studies of a library of NK1-Receptor Ligands Based on a 5-arylthiosubstituted 2-amino-4,6-diaryl-3-cyano-4H-pyran core: Switch from antagonist to agonist effect by chemical modification
(Elsevier, 2017)A library of 5-arylthiosubstituted 2-amino-4,6-diaryl-3-cyano-4H-pyrans has been synthesized as a new family of non-peptide ...
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Dietary oleacein, a secoiridoid from extra virgin olive oil, prevents collagen-induced arthritis in mice
(ROYAL SOC CHEMISTRY, 2024)Olacein (OLA), one of the main secoiridoids derived from extra virgin olive oil (EVOO), has been shown to modulate oxidative ...
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Effects of Dietary Oleacein Treatment on Endothelial Dysfunction and Lupus Nephritis in Balb/C Pristane-Induced Mice
(Multidisciplinary Digital Publishing Institute (MDPI), 2023)Systemic lupus erythematosus (SLE) is a chronic immune-inflammatory disease characterized by multiorgan affectation and ...
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Effects of Oleacein, a New Epinutraceutical Bioproduct from Extra Virgin Olive Oil, in LPS-Activated Murine Immune Cells
(MDPI, 2022)The present study was designed to evaluate the immunomodulatory effects of the secoiridoid from extra virgin olive oil, ...
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Evaluation of Anticancer Activity of 76 Plant Species Collected in Andalusia (Spain) against Lung Cancer Cells
(MDPI, 2023)Every year, cancer kills millions of people around the world. Finding more selective anticancer agents is essential to ...
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Evaluation of temocillin efficacy against KPC-2-producing Klebsiella pneumoniae isolates in a hollow-fibre infection model
(Oxford University Press, 2024-02-09)Background: Temocillin is an old antimicrobial that is resistant to hydrolysis by ESBLs but has variable activity against ...
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Extra-virgin olive oil and its phenolic extract prevent inflammatory response and joint damage in murine experimental arthritis
(Instituto de la Grasa, 2016)he consumption of EVOO in Mediterranean countries has shown beneficial effects. A wide range of evidence indicates that ...
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Functional Features of the Exopolysaccharide Extracts Produced by Lactiplantibacillus Strains Isolated from Table Olives
(Royal Society of Chemistry, 2024)This study evaluates the functional characteristics of the exopolysaccharide (EPS) extracts produced by various strains ...
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Immunomodulatory Effects of (R)-Sulforaphane on LPS-Activated Murine Immune Cells: Molecular Signaling Pathways and Epigenetic Changes in Histone Markers
(Multidisciplinary Digital Publishing Institute (MDPI), 2022)The aim of this study was to explore the immunomodulatory effects of the natural enantiomer (R)-Sulforaphane (SFN) and the ...
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Isolation and structural determination of cis- and trans-p-coumaroyl-secologanoside (comselogoside) from olive oil waste (alperujo). Photoisomerization with ultraviolet irradiation and antioxidant activities
(Elsevier, 2024-01-30)p-Coumaroyl-6́-secologanoside (comselogoside) is a secoiridoid identified in large amounts in olive fruits, although no ...
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Manipulation of Amino Acid Levels with Artificial Diets Induces a Marked Anticancer Activity in Mice with Renal Cell Carcinoma
(Multidisciplinary Digital Publishing Institute (MDPI), 2022)Targeted therapies with antiangiogenic drugs (e.g., sunitinib) and immune checkpoint inhibitors (e.g., anti-PD-1 antibodies) ...