Artículo
Dietary oleacein, a secoiridoid from extra virgin olive oil, prevents collagen-induced arthritis in mice
Autor/es | Rosillo Ramírez, María de los Ángeles
![]() ![]() ![]() ![]() ![]() ![]() ![]() Villegas Lama, Isabel ![]() ![]() ![]() ![]() ![]() ![]() ![]() Vázquez Román, María Victoria ![]() ![]() ![]() ![]() ![]() ![]() Fernández-Santos, José María ![]() ![]() ![]() ![]() ![]() Ortega Vidal, Juan Salido, Sofía González Rodríguez, María Luisa ![]() ![]() ![]() ![]() ![]() ![]() ![]() Alarcón de la Lastra Romero, Catalina ![]() ![]() ![]() ![]() ![]() ![]() ![]() |
Departamento | Universidad de Sevilla. Departamento de Citología e Histología Normal y Patológica Universidad de Sevilla. Departamento de Farmacia y Tecnología Farmacéutica Universidad de Sevilla. Departamento de Farmacología |
Fecha de publicación | 2024 |
Fecha de depósito | 2024-06-06 |
Publicado en |
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Resumen | Olacein (OLA), one of the main secoiridoids derived from extra virgin olive oil (EVOO), has been shown to modulate oxidative and inflammatory responses in various pathological conditions; however, its potential benefit in ... Olacein (OLA), one of the main secoiridoids derived from extra virgin olive oil (EVOO), has been shown to modulate oxidative and inflammatory responses in various pathological conditions; however, its potential benefit in joint disorders such as rheumatoid arthritis (RA) is unknown. Therefore, this study was designed to evaluate the preventive role of the effects of an OLA-supplemented diet in the murine model of collagen-induced arthritis (CIA), delving into the possible mechanisms and signaling pathways involved. Animals were fed an OLA-enriched preventive diet for 6 weeks prior to CIA induction and until the end of the experimental time course. On day 43 after the first immunization, mice were sacrificed: blood was collected, and paws were histologically and biochemically processed. Dietary OLA prevented collageninduced rheumatic bone, joint and cartilage conditions. Circulating matrix metalloproteinase (MMP)-3 and proinflammatory cytokine (IL-6, IL-1β, TNF-α, IL-17) levels were significantly decreased in the joint, as well as MMP-9 and cathepsin-K (CatK) expression in secoiridoid-fed animals. In addition, dietary OLA was able to decrease COX-2, mPGES-1 and iNOS protein expressions and, also, PGE2 levels. The mechanisms possibly involved in these protective effects could be related to the activation of the Nrf-2/HO-1 axis and the inhibition of proinflammatory signaling pathways, including JAK-STAT, MAPKs and NF-κB, involved in the production of inflammatory and oxidative mediators. These results support the interest of OLA, as a nutraceutical intervention, in the management of RA. |
Agencias financiadoras | Junta de Andalucía |
Identificador del proyecto | US-1380592
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Cita | Rosillo Ramírez, M.d.l.Á., Villegas Lama, I., Vázquez Román, M.V., Fernández-Santos, J.M., Ortega Vidal, J., Salido, S.,...,Alarcón de la Lastra Romero, C. (2024). Dietary oleacein, a secoiridoid from extra virgin olive oil, prevents collagen-induced arthritis in mice. Food & Function, 15 (2), 838-852. https://doi.org/10.1039/d3fo04240e. |
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Dietary oleacein_Rosillo.pdf | 1.950Mb | ![]() | Ver/ | |