dc.creator | Rosillo Ramírez, María de los Ángeles | es |
dc.creator | Villegas Lama, Isabel | es |
dc.creator | Vázquez Román, María Victoria | es |
dc.creator | Fernández-Santos, José María | es |
dc.creator | Ortega Vidal, Juan | es |
dc.creator | Salido, Sofía | es |
dc.creator | González Rodríguez, María Luisa | es |
dc.creator | Alarcón de la Lastra Romero, Catalina | es |
dc.date.accessioned | 2024-06-06T07:34:31Z | |
dc.date.available | 2024-06-06T07:34:31Z | |
dc.date.issued | 2024 | |
dc.identifier.citation | Rosillo Ramírez, M.d.l.Á., Villegas Lama, I., Vázquez Román, M.V., Fernández-Santos, J.M., Ortega Vidal, J., Salido, S.,...,Alarcón de la Lastra Romero, C. (2024). Dietary oleacein, a secoiridoid from extra virgin olive oil, prevents collagen-induced arthritis in mice. Food & Function, 15 (2), 838-852. https://doi.org/10.1039/d3fo04240e. | |
dc.identifier.issn | 2042-650X (electrónico) | es |
dc.identifier.issn | 2042-6496 (impreso) | es |
dc.identifier.uri | https://hdl.handle.net/11441/159839 | |
dc.description.abstract | Olacein (OLA), one of the main secoiridoids derived from extra virgin olive oil (EVOO), has been shown to modulate oxidative and inflammatory responses in various pathological conditions; however, its potential benefit in joint disorders such as rheumatoid arthritis (RA) is unknown. Therefore, this study was designed to evaluate the preventive role of the effects of an OLA-supplemented diet in the murine model of collagen-induced arthritis (CIA), delving into the possible mechanisms and signaling pathways involved. Animals were fed an OLA-enriched preventive diet for 6 weeks prior to CIA induction and until the end of the experimental time course. On day 43 after the first immunization, mice were sacrificed: blood was collected, and paws were histologically and biochemically processed. Dietary OLA prevented collageninduced rheumatic bone, joint and cartilage conditions. Circulating matrix metalloproteinase (MMP)-3 and proinflammatory cytokine (IL-6, IL-1β, TNF-α, IL-17) levels were significantly decreased in the joint, as well as MMP-9 and cathepsin-K (CatK) expression in secoiridoid-fed animals. In addition, dietary OLA was able to decrease COX-2, mPGES-1 and iNOS protein expressions and, also, PGE2 levels. The mechanisms possibly involved in these protective effects could be related to the activation of the Nrf-2/HO-1 axis and the inhibition of proinflammatory signaling pathways, including JAK-STAT, MAPKs and NF-κB, involved in the production of inflammatory and oxidative mediators. These results support the interest of OLA, as a nutraceutical intervention, in the management of RA. | es |
dc.description.sponsorship | Junta de Andalucía US-1380592 | es |
dc.format | application/pdf | es |
dc.format.extent | 15 p. | es |
dc.language.iso | eng | es |
dc.publisher | ROYAL SOC CHEMISTRY | es |
dc.relation.ispartof | Food & Function, 15 (2), 838-852. | |
dc.rights | Atribución 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.title | Dietary oleacein, a secoiridoid from extra virgin olive oil, prevents collagen-induced arthritis in mice | es |
dc.type | info:eu-repo/semantics/article | es |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Citología e Histología Normal y Patológica | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Farmacia y Tecnología Farmacéutica | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Farmacología | es |
dc.relation.projectID | US-1380592 | es |
dc.relation.publisherversion | https://dx.doi.org/10.1039/d3fo04240e | es |
dc.identifier.doi | 10.1039/d3fo04240e | es |
dc.journaltitle | Food & Function | es |
dc.publication.volumen | 15 | es |
dc.publication.issue | 2 | es |
dc.publication.initialPage | 838 | es |
dc.publication.endPage | 852 | es |
dc.contributor.funder | Junta de Andalucía | es |