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  DDX47, MeCP2, and other functionally heterogeneous factors protect cells from harmful R loops 

  Marchena Cruz, Esther; Camino, Lola P.; Bhandari, Jay; Pinela Da Silva, Sonia Cristina; Marqueta Gracia, José Javier; Amdeen, Shahad A.; Guillén Mendoza, Cristina; García Rubio, María Luisa; Calderón Montaño, José Manuel; Xue, Xiaoyu; Luna Varo, Rosa María; Aguilera López, Andrés (Elsevier, 2023)

  Unscheduled R loops can be a source of genome instability, a hallmark of cancer cells. Although targeted proteomic ...

• Article
  

  Artificial Diets with Altered Levels of Sulfur Amino Acids Induce Anticancer Activity in Mice with Metastatic Colon Cancer, Ovarian Cancer and Renal Cell Carcinoma 

  Jiménez Alonso, Julio José; Guillén Mancina, Emilio; Calderón Montaño, José Manuel; Jiménez González, Víctor; Díaz Ortega, Patricia; Burgos Morón, Estefanía; López Lázaro, Miguel (Multidisciplinary Digital Publishing Institute (MDPI), 2023)

  Sulfur-containing amino acids methionine (Met), cysteine (Cys) and taurine (Tau) are common dietary constituents with ...

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  Artificial Diets with Selective Restriction of Amino Acids and Very Low Levels of Lipids Induce Anticancer Activity in Mice with Metastatic Triple-Negative Breast Cancer 

  Guillén Mancina, Emilio; Jiménez Alonso, Julio José; Calderón Montaño, José Manuel; Jiménez González, Víctor; Díaz Ortega, Patricia; Burgos Morón, Estefanía; López Lázaro, Miguel (Multidisciplinary Digital Publishing Institute (MDPI), 2023)

  Current treatments for patients with metastatic triple negative breast cancer (TNBC) are generally ineffective. This ...

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  Phytochemical Analysis and Anti-Inflammatory Potential of Acanthus mollis L. Rhizome Hexane Extract 

  Acero, Nuria; Muñoz Mingarro, Dolores; Navarro Zafra, Inmaculada; León González, Antonio José; Martín Cordero, Carmen (Multidisciplinary Digital Publishing Institute (MDPI), 2023)

  The rhizomes of Acanthus mollis have traditionally been used for the treatment of several ailments involving inflammation. ...

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  Impact of Frailty on Outcomes of First-Line Pembrolizumab Monotherapy in a Real-World Population with Advanced Non-Small Cell Lung Cancer 

  Jiménez Galán, Rocío; Prado-Mel, Elena; Álvarez de Sotomayor Paz, María; Abdel-Kader Martín, Laila (MDPI, 2023)

  ICIs have been able to improve overall survival in advanced-stage lung cancer. The benefit of this therapy is limited in ...

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  Population pharmacokinetics and pharmacodynamics of fosfomycin in non-critically ill patients with bacteremic urinary infection caused by multidrug-resistant Escherichia coli 

  Merino Bohórquez, Vicente; Docobo Pérez, Fernando; Sojo Dorado, Jesús; Morales, Isabel; Lupión Mendoza, Carmen; Martín, D.; Pascual Hernández, Álvaro; Rodríguez Baño, Jesús (Elsevier, 2018)

  Objectives: To describe the population pharmacokinetics of fosfomycin for patients with bacteraemic urinary tract infection ...

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  Manipulation of Amino Acid Levels with Artificial Diets Induces a Marked Anticancer Activity in Mice with Renal Cell Carcinoma 

  Calderón Montaño, José Manuel; Guillén Mancina, Emilio; Jiménez Alonso, Julio José; Jiménez González, Víctor; Burgos Morón, Estefanía; Mate Barrero, Alfonso; Pérez Guerrero, María Concepción; López Lázaro, Miguel (Multidisciplinary Digital Publishing Institute (MDPI), 2022)

  Targeted therapies with antiangiogenic drugs (e.g., sunitinib) and immune checkpoint inhibitors (e.g., anti-PD-1 antibodies) ...

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  9-PAHPA long term intake in DIO and db/db mice ameliorates insulin sensitivity but has few effects on obesity and associated metabolic disorders 

  Bonafos, Béatrice; Cortés Espinar, Antonio J.; Balas, Laurence; Pessemesse, Laurence; Lambert, Karen; Benlebna, Melha; Gaillet, Sylvie; Ávila Román, Francisco Javier; Feillet-Coudray, Christine (Elsevier, 2023)

  Branched fatty acid esters of hydroxy fatty acids are endogenous lipids reported to have antidiabetic and anti-inflammatory ...

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  Overexpressed c-Myc Sensitizes Cells to TH1579, a Mitotic Arrest and Oxidative DNA Damage Inducer 

  Henriksson, Sofia; Calderón Montaño, José Manuel; Solvie, Daniel; Warpman Berglund, Ulrika; Helleday, Thomas (Multidisciplinary Digital Publishing Institute (MDPI), 2022)

  Previously, we reported that MTH1 inhibitors TH588 and TH1579 selectively induce oxidative damage and kill Ras-expressing ...

• Article
  

  Zebularine induces replication-dependent double-strand breaks which are preferentially repaired by homologous recombination 

  Orta Vázquez, Manuel Luis; Pastor Carrillo, Nuria María; Burgos Morón, Estefanía; Domínguez García, Inmaculada; Calderón Montaño, José Manuel; Huertas Castaño, Carlos; López Lázaro, Miguel; Helleday, Thomas; Mateos Cordero, Santiago (Elsevier, 2017)

  Zebularine is a second-generation, highly stable hydrophilic inhibitor of DNA methylation with oral bioavailability that ...

• Article
  

  Selective cytotoxic activity and DNA damage by an epoxyalkyl galactopyranoside 

  Burgos Morón, Estefanía; Pastor Carrillo, Nuria María; Orta Vázquez, Manuel Luis; Jiménez Alonso, Julio José; Vega Holm, Margarita; Vega Pérez, José Manuel; Iglesias Guerra, Fernando; Mateos Cordero, Santiago; López Lázaro, Miguel; Calderón Montaño, José Manuel (Wiley, 2018)

  Several clinically useful anticancer drugs selectively kill cancer cells by inducing DNA damage; the genomic instability ...

• Article
  

  Effects of Oleacein, a New Epinutraceutical Bioproduct from Extra Virgin Olive Oil, in LPS-Activated Murine Immune Cells 

  Muñoz García, Rocío; Sánchez Hidalgo, Marina; Montoya García, Tatiana; Alcarranza Saucedo, Manuel; Ortega Vidal, Juan; Altarejos, Joaquin; Alarcón de la Lastra Romero, Catalina (MDPI, 2022)

  The present study was designed to evaluate the immunomodulatory effects of the secoiridoid from extra virgin olive oil, ...

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  Drug–drug interactions between treatment specific pharmacotherapy and concomitant medication in patients with COVID-19 in the first wave in Spain 

  Cantudo-Cuenca, M. D.; Gutiérrez-Pizarraya, Antonio; Pinilla-Fernández, Ana; Contreras-Macías, Enrique; Fernández‑Fuertes, M.; Pineda Vergara, Juan Antonio; Macías Sánchez, Juan; Morillo Verdugo, Ramón Alejandro (NATURE PUBLISHING GROUP, 2021)

  Primary aim was to assess prevalence and severity of potential and real drug–drug interactions (DDIs) among therapies for ...

• Article
  

  pH-temperature dual-sensitive nucleolipid-containing stealth liposomes anchored with PEGylated AuNPs for triggering delivery of doxorubicin 

  García, Mónica C.; Calderón Montaño, José Manuel; Rueda Rueda, Manuela; Longhi, Marcela; Rabasco Álvarez, Antonio María; López Lázaro, Miguel; Prieto Dapena, Francisco; González Rodríguez, María Luisa (Elsevier, 2022)

  Liposomes (Lip) are useful nanocarriers for drug delivery and cancer nanomedicine because of their ability to efficiently ...

• Article
  

  ¿Reducen las estatinas el riesgo de glaucoma? revisión de las evidencias 

  Álvarez de Sotomayor Paz, María; Pastor Plana, Laura (Universidad de Granada, 2021)

  Introducción: Los objetivos de este trabajo son revisar y resumir los datos publicados hasta el momento que relacionen el ...

• Article
  

  Plantas medicinales que actúan sobre el sistema inmune 

  Perejón Rubio, Inmaculada del Rocío; García Giménez, María Dolores (Universidad de Granada, 2022)

  Introducción: El sistema inmune puede verse afectado por distintos factores, por lo que en ocasiones el ...

• Article
  

  Outpatients’ Opinion And Experience Regarding Telepharmacy During The COVID-19 Pandemic: The Enopex Project 

  Margusino Framiñán, Luis; Fernández Llamazares, Cecilia M.; Negro Vega, Eva; Tortajada Goitia, Begoña; Lizeaga, Garbiñe; Mercadal Orfila, Gabriel; Almeida González, Carmen V.; Morillo Verdugo, Ramón Alejandro (Taylor and Francis Group, 2021)

  Background: Telepharmacy, as a remote pharmaceutical care procedure, is being used worldwide during the COVID-19 pandemic, ...

• Article
  

  Preparation, characterization and evaluation of the anti-inflammatory activity of epichlorohydrin-β-cyclodextrin/curcumin binary systems embedded in a pluronic® /hyaluronate hydrogel 

  Fernández Romero, Ana María; Maestrelli, Francesca; García Gil, Sara; Talero Barrientos, Elena Mª; Mura, Paola Angela; Rabasco Álvarez, Antonio María; González Rodríguez, María Luisa (Multidisciplinary Digital Publishing Institute (MDPI), 2021)

  Curcumin (Cur) is an anti-inflammatory polyphenol that can be complexed with polymeric cyclodextrin (CD) to improve ...

• Article
  

  Effectiveness of Fosfomycin for the Treatment of Multidrug-Resistant Escherichia coli Bacteremic Urinary Tract Infections A Randomized Clinical Trial 

  Sojo Dorado, Jesús; López Hernández, Inmaculada; Rosso Fernández, Clara; Morales, Isabel; Palacios-Baena, Zaira R.; Hernández Torres, Alicia; Lobo Acosta, María Ángeles; Merino Bohórquez, Vicente; Pascual Hernández, Álvaro; Rodríguez-Baño, Jesús; Retamar Gentil, Pilar (Jama Nerwork Open, 2022)

  Importance The consumption of broad-spectrum drugs has increased as a consequence of the spread of multidrug-resistant ...

• Article
  

  Artificial Diets Based on Selective Amino Acid Restriction versus Capecitabine in Mice with Metastatic Colon Cancer 

  Jiménez Alonso, Julio José; Guillén Mancina, Emilio; Calderón Montaño, José Manuel; Jiménez González, Víctor; Díaz Ortega, Patricia; Burgos Morón, Estefanía; López Lázaro, Miguel (MDPI, 2022)

  New therapies are needed to improve the low survival rates of patients with metastatic colon cancer. Evidence suggests ...

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