Artículo
Manipulation of Amino Acid Levels with Artificial Diets Induces a Marked Anticancer Activity in Mice with Renal Cell Carcinoma
Autor/es | Calderón Montaño, José Manuel
Guillén Mancina, Emilio Jiménez Alonso, Julio José Jiménez González, Víctor Burgos Morón, Estefanía Mate Barrero, Alfonso Pérez Guerrero, María Concepción López Lázaro, Miguel |
Departamento | Universidad de Sevilla. Departamento de Farmacología Universidad de Sevilla. Departamento de Fisiología |
Fecha de publicación | 2022 |
Fecha de depósito | 2023-01-19 |
Publicado en |
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Resumen | Targeted therapies with antiangiogenic drugs (e.g., sunitinib) and immune checkpoint inhibitors (e.g., anti-PD-1 antibodies) are the standard of care for patients with metastatic renal cell carcinoma. Although these ... Targeted therapies with antiangiogenic drugs (e.g., sunitinib) and immune checkpoint inhibitors (e.g., anti-PD-1 antibodies) are the standard of care for patients with metastatic renal cell carcinoma. Although these treatments improve patient survival, they are rarely curative. We previously hypothesized that advanced cancers might be treated without drugs by using artificial diets in which the levels of specific amino acids (AAs) are manipulated. In this work, after showing that AA manipulation induces selective anticancer activity in renal cell carcinoma cells in vitro, we screened 18 artificial diets for anticancer activity in a challenging animal model of renal cell carcinoma. The model was established by injecting murine renal cell carcinoma (Renca) cells into the peritoneum of immunocompetent BALB/cAnNRj mice. Mice survival was markedly improved when their normal diet was replaced with our artificial diets. Mice fed a diet lacking six AAs (diet T2) lived longer than mice treated with sunitinib or anti-PD-1 immunotherapy; several animals lived very long or were cured. Controlling the levels of several AAs (e.g., cysteine, methionine, and leucine) and lipids was important for the anticancer activity of the diets. Additional studies are needed to further evaluate the therapeutic potential and mechanism of action of this simple and inexpensive anticancer strategy. |
Agencias financiadoras | Junta de Andalucía Universidad de Sevilla |
Identificador del proyecto | PRJ201803388
2017/CTS-657 2019/CTS-657 2021/CTS-657 VIPPIT-2019-I.5 VIPPIT-2020-I.5 VIPPIT-2021-I.5 VIPPIT-2020-II.3 |
Cita | Calderón Montaño, J.M., Guillén Mancina, E., Jiménez Alonso, J.J., Jiménez González, V., Burgos Morón, E., Mate Barrero, A.,...,López Lázaro, M. (2022). Manipulation of Amino Acid Levels with Artificial Diets Induces a Marked Anticancer Activity in Mice with Renal Cell Carcinoma. International Journal of Molecular Sciences, 23 (24), 16132. https://doi.org/10.3390/ijms232416132. |
Ficheros | Tamaño | Formato | Ver | Descripción |
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Manipulation of Amino.pdf | 5.401Mb | [PDF] | Ver/ | |
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