Data

NameLópez Lázaro, Miguel
DepartmentFarmacología
Knowledge areaFarmacología
Professional categoryProfesor Titular de Universidad
E-mailRequest
           

  Statistics

  • Items

    36

  • Visits

    6063

  • Downloads

    8596

  Publications

 

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Carbohydrate-Based NK1R Antagonists with Broad-Spectrum Anticancer Activity

Recio Jiménez, Rocío; Lerena Pérez, Patricia; Pozo Torres, Esther; Calderón Montaño, José Manuel; Burgos Morón, Estefanía; López Lázaro, Miguel; Valdivia Giménez, Victoria Esther; Pernia Leal, Manuel; Mouillac, Bernard; Organero, Juan Ángel; Khiar, Noureddine; Fernández Fernández, Inmaculada (American Chemical Society, 2021-01-01)
NK1R antagonists, investigated for the treatment of several pathologies, have shown encouraging results in the treatment ...
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Screening for selective anticancer activity of 65 extracts of plants collected in Western Andalusia, Spain

Calderón Montaño, José Manuel; Martínez Sánchez, Sara María; Jiménez González, Víctor; Burgos Morón, Estefanía; Guillén Mancina, Emilio; Jiménez Alonso, Julio José; Díaz Ortega, Patricia; García Martín, Felipe José; Aparicio Martínez, Abelardo; López Lázaro, Miguel (Multidisciplinary Digital Publishing Institute (MDPI), 2021-01-01)
Finding cytotoxic drugs with a high selectivity towards cancer cells is crucial to improve the low survival rates of ...
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Cholesterol levels affect the performance of aunps-decorated thermo-sensitive liposomes as nanocarriers for controlled doxorubicin delivery

García, Mónica C.; Naitlho, Nabila; Calderón Montaño, José Manuel; Drago, Estrella; Rueda Rueda, Manuela; Longhi, Marcela; Rabasco Álvarez, Antonio María; López Lázaro, Miguel; Prieto Dapena, Francisco; González Rodríguez, María Luisa (Multidisciplinary Digital Publishing Institute (MDPI), 2021-01-01)
Stimulus-responsive liposomes (L) for triggering drug release to the target site are particularly useful in cancer therapy. ...
PhD Thesis
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Investigación de la selectividad anticancerosa de nuevos compuestos y estrategias contra el cáncer

López Lázaro, Miguel; Guillén Mancina, Emilio (2020-09-25)
El cáncer es una enfermedad muy común y muy difícil de tratar. Las estadísticas actuales sobre el cáncer muestran que una ...
Final Degree Project
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Farmacoterapia del cáncer de ovario epitelial. Posibles interacciones entre carboplatino y suplementos alimenticios

López Lázaro, Miguel; Rodríguez Barrera, Adrián (2020-06-01)
El cáncer de ovario es el quinto tipo de cáncer que afecta con más frecuencia a las mujeres, siendo el más letal dentro ...
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Meroterpenoids from the Brown Alga Cystoseira usneoides as Potential Anti-Inflammatory and Lung Anticancer Agents

Zbakh, Hanaa; Zubía, Eva; Reyes, Carolina de los; Calderón Montaño, José Manuel; López Lázaro, Miguel; Motilva Sánchez, Virginia (MDPI, 2020-01-01)
The anti-inflammatory and anticancer properties of eight meroterpenoids isolated from the brown seaweed Cystoseira usneoides ...
Final Degree Project
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Farmcoterapia del cáncer de colon metastásico

López Lázaro, Miguel; Laguna Rastrojo, Lucía (2019-06-01)
En España, más 37.000 personas son diagnosticadas de cáncer colorrectal al año. Es el cáncer con mayor incidencia teniendo ...
Final Degree Project
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Farmacoterapia del cáncer renal metastásico

López Lázaro, Miguel; Montijano Castillo, María (2019-01-01)
El cáncer renal es uno de los 10 cánceres más comunes del mundo , represe ntando aproximadamente ...
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The Cockayne syndrome protein B is involved in the repair of 5-AZA-2′-deoxycytidine-induced DNA lesions

Burgos Morón, Estefanía; Calderón Montaño, José Manuel; Pastor Carrillo, Nuria María; Ruiz Castizo, Ángel; Domínguez García, Inmaculada; López Lázaro, Miguel; Mateos Cordero, Santiago; Orta Vázquez, Manuel Luis (Impact Journals, 2018-01-01)
The Cockayne Syndrome Protein B (CSB) plays an essential role in Transcription-Coupled Nucleotide Excision Repair (TC-NER) ...
Final Degree Project
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Biología y terapia del retinoblastoma

López Lázaro, Miguel; Redondo Galán, Carmen (2017-07-01)
El retinoblastoma es un tumor intraocular poco frecuente en la infancia que se produce en las células de la retina en ...
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A local mechanism by which alcohol consumption causes cancer

López Lázaro, Miguel (2016-01-01)
Epidemiological data indicate that 5.8% of cancer deaths world-wide are attributable to alcohol consumption. The risk of ...
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Cells Deficient in the Fanconi Anemia Protein FANCD2 are Hypersensitive to the Cytotoxicity and DNA Damage Induced by Coffee and Caffeic Acid

Burgos Morón, Estefanía; Calderón Montaño, José Manuel; Orta Vázquez, Manuel Luis; Guillén Mancina, Emilio; Mateos Cordero, Santiago; López Lázaro, Miguel (MDPI AG, 2016-01-01)
Epidemiological studies have found a positive association between coffee consumption and a lower risk of cardiovascular ...
Final Degree Project
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Prevención del cáncer mediante el control del factor de crecimiento insulínico tipo I.

López Lázaro, Miguel; Medina Guerrero, Ana (2016-01-01)
Para prevenir el cáncer de forma eficaz es importante conocer cómo se origina y cómo se desarrolla la enfermedad. Evidencias ...
PhD Thesis
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Estudio del daño en el ADN inducido por compuestos polifenólicos de la dieta

López Lázaro, Miguel; Burgos Morón, Estefanía (2015-11-27)
El cáncer es una enfermedad causada por la acumulación de daño en el ADN . Las células cancerosas presentan numerosas ...
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Understanding why aspirin prevents cancer and why consuming very hot beverages and foods increases esophageal cancer risk. Controlling the division rates of stem cells is an important strategy to prevent cancer.

López Lázaro, Miguel (2015-01-01)
Cancer is, in essence, a stem cell disease. The main biological cause of cancer is that stem cells acquire DNA alterations ...
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The migration ability of stem cells can explain the existence of cancer of unknown primary site. Rethinking metastasis.

López Lázaro, Miguel (2015-01-01)
Cancers of unknown primary site are metastatic cancers for which primary tumors are not found after detailed investigations. ...
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Selective amino acid restriction therapy (SAART): a non-pharmacological strategy against all types of cancer cells

López Lázaro, Miguel (2015-01-01)
Metastasis will continue to be an incurable disease for most patients until we develop highly selective anticancer therapies. ...
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Two preclinical tests to evaluate anticancer activity and to help validate drug candidates for clinical trials.

López Lázaro, Miguel (2015-01-01)
Current approaches to assessing preclinical anticancer activity do not reliably predict drug efficacy in cancer patients. ...
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Effect of DNA repair deficiencies on the cytotoxicity of resveratrol

López Lázaro, Miguel; López Lázaro, Miguel; Burgos Morón, Estefanía; Calderón Montaño, José Manuel; Orta Vázquez, Manuel Luis; Mateos Cordero, Santiago (2015-01-01)
Numerous preclinical studies have shown that the naturally-occurring polyphenol resveratrol may produce health-beneficial ...
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Evaluating the cancer therapeutic potential of cardiac glycosides

Calderón Montaño, José Manuel; Burgos Morón, Estefanía; Orta Vázquez, Manuel Luis; Maldonado Navas, Dolores; García Domínguez, Irene; López Lázaro, Miguel (Hindawi Publishing Corporation, 2014-01-01)
Cardiac glycosides, also known as cardiotonic steroids, are a group of natural products that share a steroid-like structure ...
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The PARP inhibitor Olaparib disrupts base excision repair of 5-aza-2′-deoxycytidine lesions

Orta Vázquez, Manuel Luis; Calderón Montaño, José Manuel; Domínguez García, Inmaculada; Burgos Morón, Estefanía; Pastor Carrillo, Nuria María; López Lázaro, Miguel; Helleday, Thomas (Oxford University Press, 2014-01-01)
Decitabine (5-aza-21-deoxycytidine, 5-azadC) is used in the treatment of Myelodysplatic syndrome (MDS) and Acute Myeloid ...
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Sulforaphane homologues: Enantiodivergent synthesis of both enantiomers, activationof the Nrf2 transcription factor and selective cytotoxic activity

Elhalem, Eleonora; Recio Jiménez, Rocío; Werner, Sabine; Lieder, Franziska; Calderón Montaño, José Manuel; López Lázaro, Miguel; Fernández Fernández, Inmaculada; Khiar, Noureddine (Elsevier, 2014-01-01)
Reported is an enantiodivergent approach for the synthesis of both enantiomers of sulforaphane (SFN) homologues with ...
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Induction of Apoptosis and Cell Cycle Arrest in Human Colon Carcinoma Cells by Corema album Leaves

León González, Antonio José; Manson, Margaret M.; López Lázaro, Miguel; Navarro Zafra, Inmaculada; Martín Cordero, Carmen (SAGE Publications, 2014-01-01)
The leaves of Corema album (Ericaceae), an endemic shrub which grows in Atlantic coastal areas of the Iberian Peninsula, ...
PhD Thesis
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Evaluación de nuevas estrategias para el desarrollo de terapias anticancerosas selectivas

López Lázaro, Miguel; Calderón Montaño, José Manuel (2013-07-01)
Evaluación de nuevas estrategias para el desarrollo de terapias anticancerosas selectivas El cáncer es una enfermedad ...
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Dichloroacetate, 2-Deoxyglucose and a Hydroalcoholic Extract from the Skin of the Fruit of Solanum melongena (Aubergine) Induce Selective Anticancer Activity against Melanoma Cells

Calderón Montaño, José Manuel; Burgos Morón, Estefanía; Martínez Sánchez, Sara María; López Lázaro, Miguel (Biomedical Publisher, 2013-01-01)
Prognosis of melanoma patients with metastatic disease is very poor. For example, over 95% of melanoma patients with three ...
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Comment on ‘Quiescence and γH2AX in neuroblastoma are regulated by Ouabain/Na,K-ATPase': ouabain and cáncer

Calderón Montaño, José Manuel; Burgos Morón, Estefanía; López Lázaro, Miguel (Nature Publishing Group, 2013-01-01)
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Vitamin C and the Red Wine Polyphenol Resveratrol - but not Curcumin and the Glycolysis Inhibitors 2- Deoxyglucose, Dichloroacetate and 3-Bromopyruvate - Induce Selective Cytotoxicity against Lung Cancer Cells.

Calderón Montaño, José Manuel; Burgos Morón, Estefanía; Martínez Sánchez, Sara María; López Lázaro, Miguel (Biomedical Publisher, 2013-01-01)
Cancer statistics show that the most commonly diagnosed cancer in the world is lung cancer, that over 50% of patients ...
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A hydroalcoholic extract from the leaves of Nerium oleander inhibits glycolysis and induces selective killing of lung cancer cells

Calderón Montaño, José Manuel; Burgos Morón, Estefanía; Orta Vázquez, Manuel Luis; Mateos Cordero, Santiago; López Lázaro, Miguel (Georg Thieme Verlag, 2013-01-01)
Recent evidence suggests that cardiac glycosides might be used for the treatment of cancer. The ornamental shrub Nerium ...
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The Cardiac Glycosides Digitoxin, Digoxin and Ouabain Induce a Potent Inhibition of Glycolysis in Lung Cancer Cells

Calderón Montaño, José Manuel; Burgos Morón, Estefanía; López Lázaro, Miguel (Biomedical Publisher, 2013-01-01)
Cardiac glycosides are promising anticancer drugs. We have recently shown that the cardiac glycosides digitoxin, digoxin ...
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5-Aza-2'-deoxycytidine causes replication lesions that require Fanconi anemia-dependent homologous recombination for repair

Orta Vázquez, Manuel Luis; Calderón Montaño, José Manuel; Domínguez García, Inmaculada; Pastor Carrillo, Nuria María; Burgos Morón, Estefanía; López Lázaro, Miguel; Cortés, Felipe; Mateos Cordero, Santiago; Helleday, Thomas (Oxford University Press, 2013-01-01)
5-Aza-2'-deoxycytidine (5-azadC) is a DNA methyltransferase (DNMT) inhibitor increasingly used in treatments of hematological ...
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Consumption of the Dietary Flavonoids Quercetin, Luteolin and Kaempferol and Overall Risk of Cancer - A Review and Meta-Analysis of the Epidemiological Data

López Lázaro, Miguel; Burgos Morón, Estefanía; Tena, J.D.; Sanz, I.; Sainz, J; Calderón Montaño, José Manuel (Biomedical Publisher, 2013-01-01)
Numerous epidemiological and preclinical studies suggest that flavonoids may play an important role in the decreased risk ...
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Role of the Intracellular pH in the Metabolic Switch between Oxidative Phosphorylation and AerobicGlycolysis - Relevance to Cancer

Calderón Montaño, José Manuel; Burgos Morón, Estefanía; Pérez Guerrero, María Concepción; Salvador Bofill, Francisco Javier; Robles Frías, Antonio; López Lázaro, Miguel (Biomedical Publisher, 2011-01-01)
Cellular energy in the form of ATP can be produced through oxidative phosphorylation and through glycolysis. Since oxidative ...
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Digoxin, HIF-1, and cancer

López Lázaro, Miguel (National Academy of Sciences, 2009-01-01)
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Cytotoxic activity of methanolic extract and two alkaloids extracted from seeds of Peganum harmala L.

Berrougui, Hicham; López Lázaro, Miguel; Martín Cordero, Carmen; Mamouchi, Mohamed; Ettaib, Abdelkader; Herrera González, María Dolores (Natural Remedies Pvt Ltd, 2005-01-01)
To study the cytotoxic activity of P. harmala. Materials and method: The alkaloids harmine and harmaline have been isolated ...
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Anti-tumour activity of Digitalis purpurea L. subsp. heywoodii

López Lázaro, Miguel; Palma de la Peña, Nieves; Pastor Carrillo, Nuria María; Martín Cordero, Carmen; Navarro, Eduardo; Cortés Benavides, Felipe; Ayuso, María Jesús; Toro Sainz, María Victoria (Georg Thieme Verlag, 2003-01-01)
Recent research has shown the anticancer effects of digitalis compounds suggesting their possible use in medical oncology. ...