Screening for selective anticancer activity of 65 extracts of plants collected in Western Andalusia, Spain
|Author||Calderón Montaño, José Manuel
Martínez Sánchez, Sara María
Jiménez González, Víctor
Burgos Morón, Estefanía
Guillén Mancina, Emilio
Jiménez Alonso, Julio José
Díaz Ortega, Patricia
García Martín, Felipe José
Aparicio Martínez, Abelardo
López Lázaro, Miguel
|Department||Universidad de Sevilla. Departamento de Farmacología
Universidad de Sevilla. Departamento de Biología Vegetal y Ecología
|Abstract||Finding cytotoxic drugs with a high selectivity towards cancer cells is crucial to improve the low survival rates of patients diagnosed with metastatic cancers. Since plants are an important source of anticancer drugs, we ...
Finding cytotoxic drugs with a high selectivity towards cancer cells is crucial to improve the low survival rates of patients diagnosed with metastatic cancers. Since plants are an important source of anticancer drugs, we have screened 65 extracts from 45 plants collected in several areas of Western Andalusia (Spain) for cytotoxic activity on lung cancer cells versus lung normal cells. An extract from the leaves of Tetraclinis articulata (Vahl) Mast. (Cupressaceae) showed a marked cytotoxicity (IC50 = 0.37 ± 0.03 µg/mL) and selectivity (selectivity index = 378.3) against the lung cancer cells; cisplatin, 5-fluorouracil, and an extract from the leaves of Taxus baccata L. (Taxaceae) were less cytotoxic and selective. Extracts from Cascabela thevetia (L.) Lippold (Apocynaceae), Frangula alnus Mill. (Rhamnaceae), Iberis ciliata subsp. contracta (Pers.) Moreno (Brassicaceae), Juniperus macrocarpa Sm (Cupressaceae), and Pancratium maritimum L. (Amaryllidaceae) also showed selective cytotoxicity (selectivity index > 10). Active extracts were also tested against a panel of cancer cell lines from a variety tissues. The plants identified in this work are potential sources of natural compounds with selective toxicity towards cancer cells.
|Citation||Calderón Montaño, J.M., Martínez Sánchez, S.M., Jiménez González, V., Burgos Morón, E., Guillén Mancina, E., Jiménez Alonso, J.J.,...,López Lázaro, M. (2021). Screening for selective anticancer activity of 65 extracts of plants collected in Western Andalusia, Spain. Plants, 10 (10), 2193.|