Artículo
Cholesterol levels affect the performance of aunps-decorated thermo-sensitive liposomes as nanocarriers for controlled doxorubicin delivery
Autor/es | García, Mónica C.
Naitlho, Nabila Calderón Montaño, José Manuel Drago, Estrella Rueda Rueda, Manuela Longhi, Marcela Rabasco Álvarez, Antonio María López Lázaro, Miguel Prieto Dapena, Francisco González Rodríguez, María Luisa |
Departamento | Universidad de Sevilla. Departamento de Farmacia y Tecnología Farmacéutica Universidad de Sevilla. Departamento de Farmacología Universidad de Sevilla. Departamento de Química Física |
Fecha de publicación | 2021 |
Fecha de depósito | 2022-01-05 |
Publicado en |
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Resumen | Stimulus-responsive liposomes (L) for triggering drug release to the target site are particularly useful in cancer therapy. This research was focused on the evaluation of the effects of cholesterol levels in the performance ... Stimulus-responsive liposomes (L) for triggering drug release to the target site are particularly useful in cancer therapy. This research was focused on the evaluation of the effects of cholesterol levels in the performance of gold nanoparticles (AuNPs)-functionalized L for controlled doxorubicin (D) delivery. Their interfacial and morphological properties, drug release behavior against temperature changes and cytotoxic activity against breast and ovarian cancer cells were studied. Langmuir isotherms were performed to identify the most stable combination of lipid components. Two mole fractions of cholesterol (3.35 mol% and 40 mol%, L1 and L2 series, respectively) were evaluated. Thin-film hydration and transmembrane pH-gradient methods were used for preparing the L and for D loading, respectively. The cationic surface of L allowed the anchoring of negatively charged AuNPs by electrostatic interactions, even inducing a shift in the zeta potential of the L2 series. L exhibited nanometric sizes and spherical shape. The higher the proportion of cholesterol, the higher the drug loading. D was released in a controlled manner by diffusion-controlled mechanisms, and the proportions of cholesterol and temperature of release media influenced its release profiles. D-encapsulated L preserved its antiproliferative activity against cancer cells. The developed liposomal formulations exhibit promising properties for cancer treatment and potential for hyperthermia therapy. |
Identificador del proyecto | CTQ2014- 57515-C2-1 |
Cita | García, M.C., Naitlho, N., Calderón Montaño, J.M., Drago, E., Rueda Rueda, M., Longhi, M.,...,González Rodríguez, M.L. (2021). Cholesterol levels affect the performance of aunps-decorated thermo-sensitive liposomes as nanocarriers for controlled doxorubicin delivery. Pharmaceutics, 13 (7), 973. |
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