Artículo
Curcumin as a DNA Topoisomerase II Poison
Autor/es | Martín Cordero, Carmen
López Lázaro, Miguel Gálvez, Marina Ayuso, Maria Jesús |
Departamento | Universidad de Sevilla. Departamento de Farmacología |
Fecha de publicación | 2003 |
Fecha de depósito | 2022-04-08 |
Publicado en |
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Resumen | Curcumin, the major active component of the spice
turmeric, is recognised as a safe compound with great
potential for cancer chemoprevention and cancer therapy.
It induces apoptosis, but its initiation mechanism
remains ... Curcumin, the major active component of the spice turmeric, is recognised as a safe compound with great potential for cancer chemoprevention and cancer therapy. It induces apoptosis, but its initiation mechanism remains poorly understood. Curcumin has been assessed on the human cancer cell lines, TK-10, MCF-7 and UACC62, and their IC50 values were 12.16, 3.63, 4.28 mM respectively. The possibility of this compound being a topoisomerase II poison has also been studied and it was found that 50 mM of curcumin is active in a similar fashion to the antineoplastic agent etoposide. These results point to DNA damage induced by topoisomerase II poisoning as a possible mechanism by which curcumin initiates apoptosis, and increase the evidence suggesting its possible use in cancer therapy. |
Agencias financiadoras | Ministerio de Ciencia y Tecnología (MCYT). España |
Identificador del proyecto | SAF 2000-0167 |
Cita | Martín Cordero, C., López Lázaro, M., Gálvez, M. y Ayuso, M.J. (2003). Curcumin as a DNA Topoisomerase II Poison. Journal of Enzyme Inhibition and Medicinal Chemistry, 18 (6), 505-509. |
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