dc.creator | Martín Cordero, Carmen | es |
dc.creator | López Lázaro, Miguel | es |
dc.creator | Gálvez, Marina | es |
dc.creator | Ayuso, Maria Jesús | es |
dc.date.accessioned | 2022-04-08T11:40:46Z | |
dc.date.available | 2022-04-08T11:40:46Z | |
dc.date.issued | 2003 | |
dc.identifier.citation | Martín Cordero, C., López Lázaro, M., Gálvez, M. y Ayuso, M.J. (2003). Curcumin as a DNA Topoisomerase II Poison. Journal of Enzyme Inhibition and Medicinal Chemistry, 18 (6), 505-509. | |
dc.identifier.issn | 1475-6366 | es |
dc.identifier.uri | https://hdl.handle.net/11441/131993 | |
dc.description.abstract | Curcumin, the major active component of the spice
turmeric, is recognised as a safe compound with great
potential for cancer chemoprevention and cancer therapy.
It induces apoptosis, but its initiation mechanism
remains poorly understood. Curcumin has been assessed
on the human cancer cell lines, TK-10, MCF-7 and UACC62, and their IC50 values were 12.16, 3.63, 4.28 mM
respectively. The possibility of this compound being a
topoisomerase II poison has also been studied and it was
found that 50 mM of curcumin is active in a similar
fashion to the antineoplastic agent etoposide. These
results point to DNA damage induced by topoisomerase
II poisoning as a possible mechanism by which curcumin
initiates apoptosis, and increase the evidence suggesting
its possible use in cancer therapy. | es |
dc.description.sponsorship | Ministerio de Ciencia y Tecnología de España. SAF 2000-0167 | es |
dc.format | application/pdf | es |
dc.format.extent | 5 p. | es |
dc.language.iso | eng | es |
dc.publisher | Taylor & Francis Open Access | es |
dc.relation.ispartof | Journal of Enzyme Inhibition and Medicinal Chemistry, 18 (6), 505-509. | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | curcumin | es |
dc.subject | SRB assay | es |
dc.subject | cytotoxicity | es |
dc.subject | topoisomerase poison | es |
dc.subject | topoisomerase II | es |
dc.title | Curcumin as a DNA Topoisomerase II Poison | es |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Farmacología | es |
dc.relation.projectID | SAF 2000-0167 | es |
dc.relation.publisherversion | https://doi.org/10.1080/14756360310001613085 | es |
dc.identifier.doi | 10.1080/14756360310001613085 | es |
dc.journaltitle | Journal of Enzyme Inhibition and Medicinal Chemistry | es |
dc.publication.volumen | 18 | es |
dc.publication.issue | 6 | es |
dc.publication.initialPage | 505 | es |
dc.publication.endPage | 509 | es |
dc.identifier.sisius | 6609353 | es |
dc.contributor.funder | Ministerio de Ciencia y Tecnología (MCYT). España | es |