Artículo
Artificial Diets Based on Selective Amino Acid Restriction versus Capecitabine in Mice with Metastatic Colon Cancer
Autor/es | Jiménez Alonso, Julio José
Guillén Mancina, Emilio Calderón Montaño, José Manuel Jiménez González, Víctor Díaz Ortega, Patricia Burgos Morón, Estefanía López Lázaro, Miguel |
Departamento | Universidad de Sevilla. Departamento de Farmacología |
Fecha de publicación | 2022 |
Fecha de depósito | 2022-09-30 |
Publicado en |
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Resumen | New therapies are needed to improve the low survival rates of patients with metastatic colon cancer. Evidence suggests that amino acid (AA) restriction can be used to target the altered metabolism of cancer cells. In this ... New therapies are needed to improve the low survival rates of patients with metastatic colon cancer. Evidence suggests that amino acid (AA) restriction can be used to target the altered metabolism of cancer cells. In this work, we evaluated the therapeutic potential of selective AA restriction in colon cancer. After observing anticancer activity in vitro, we prepared several artificial diets and evaluated their anticancer activity in two challenging animal models of metastatic colon cancer. These models were established by injecting CT26.WT murine colon cancer cells in the peritoneum (peritoneal dissemination) or in the tail vein (pulmonary metastases) of immunocompetent BALB/cAnNRj mice. Capecitabine, which is a first-line treatment for patients with metastatic colon cancer, was also evaluated in these models. Mice fed diet TC1 (a diet lacking 10 AAs) and diet TC5 (a diet with 6% casein, 5% glutamine, and 2.5% leucine) lived longer than untreated mice in both models; several mice survived the treatment. Diet TC5 was better than several cycles of capecitabine in both cancer models. Cysteine supplementation blocked the activity of diets TC1 and TC5, but cysteine restriction was not sufficient for activity. Our results indicated that artificial diets based on selective AA restriction have therapeutic potential for colon cancer. |
Agencias financiadoras | Junta de Andalucía Universidad de Sevilla |
Identificador del proyecto | 2017/CTS-657; 2019/CTS-657; 2021/CTS657
grant numbers VIPPIT2019-I.5, VIPPIT-2020-I.5, VIPPIT-2021-I.5, and VIPPIT-2020-II.3 |
Cita | Jiménez Alonso, J.J., Guillén Mancina, E., Calderón Montaño, J.M., Jiménez González, V., Díaz Ortega, P., Burgos Morón, E. y López Lázaro, M. (2022). Artificial Diets Based on Selective Amino Acid Restriction versus Capecitabine in Mice with Metastatic Colon Cancer. Nutrients, 14 (16), 3378. |
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