Artículo
Flavonoids As DNA Topoisomerase I Poisons
Autor/es | López Lázaro, Miguel
Martín Cordero, Carmen Toro, M. V. Ayuso, María Jesús |
Departamento | Universidad de Sevilla. Departamento de Farmacología |
Fecha de publicación | 2002 |
Fecha de depósito | 2022-04-08 |
Publicado en |
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Resumen | The therapeutic anticancer potential of flavonoids shown
by recent research needs a greater understanding of these
compounds. They are antioxidants and antimutagenic
agents that can inhibit tumor promotion and transformation ... The therapeutic anticancer potential of flavonoids shown by recent research needs a greater understanding of these compounds. They are antioxidants and antimutagenic agents that can inhibit tumor promotion and transformation and can modify the activity of a large number of mammalian enzyme systems, such as human DNAtopoisomerases. Poisons of topoisomerases generate toxic DNA damage by stabilization of the covalent DNA-topoisomerase cleavage complex and some of them have therapeutic efficacy in human cancer. The present investigation has assayed ten flavonoids, isolated in our laboratory, as topoisomerase I poisons obtaining myricetin and myricetin-3-galactoside as two new topoiosomerase I poisons. These two flavonoids, and the plant extract from which they were isolated, were assayed for cytotoxic activity against three human cancer cell lines using the SRB assay. Taking into account our previous research, structural requisites implicated in the topoisomerase poisoning are discussed. |
Agencias financiadoras | Ministerio de Ciencia y Tecnología (MCYT). España |
Identificador del proyecto | SAF 2000-0167 |
Cita | López Lázaro, M., Martín Cordero, C., Toro, M.V. y Ayuso, M.J. (2002). Flavonoids As DNA Topoisomerase I Poisons. Journal of Enzyme Inhibition and Medicinal Chemistry, 17 (1), 25-29. |
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