dc.creator | López Lázaro, Miguel | es |
dc.creator | Martín Cordero, Carmen | es |
dc.creator | Toro, M. V. | es |
dc.creator | Ayuso, María Jesús | es |
dc.date.accessioned | 2022-04-08T11:55:26Z | |
dc.date.available | 2022-04-08T11:55:26Z | |
dc.date.issued | 2002 | |
dc.identifier.citation | López Lázaro, M., Martín Cordero, C., Toro, M.V. y Ayuso, M.J. (2002). Flavonoids As DNA Topoisomerase I Poisons. Journal of Enzyme Inhibition and Medicinal Chemistry, 17 (1), 25-29. | |
dc.identifier.issn | 1475-6366 | es |
dc.identifier.uri | https://hdl.handle.net/11441/131994 | |
dc.description.abstract | The therapeutic anticancer potential of flavonoids shown
by recent research needs a greater understanding of these
compounds. They are antioxidants and antimutagenic
agents that can inhibit tumor promotion and transformation and can modify the activity of a large number of
mammalian enzyme systems, such as human DNAtopoisomerases. Poisons of topoisomerases generate
toxic DNA damage by stabilization of the covalent
DNA-topoisomerase cleavage complex and some of them
have therapeutic efficacy in human cancer. The present
investigation has assayed ten flavonoids, isolated in our
laboratory, as topoisomerase I poisons obtaining myricetin and myricetin-3-galactoside as two new topoiosomerase I poisons. These two flavonoids, and the plant
extract from which they were isolated, were assayed for
cytotoxic activity against three human cancer cell lines
using the SRB assay. Taking into account our previous
research, structural requisites implicated in the
topoisomerase poisoning are discussed. | es |
dc.description.sponsorship | Ministerio de Ciencia y Tecnología de España. SAF 2000-0167 | es |
dc.format | application/pdf | es |
dc.format.extent | 5 p. | es |
dc.language.iso | eng | es |
dc.publisher | Taylor & Francis Open Access | es |
dc.relation.ispartof | Journal of Enzyme Inhibition and Medicinal Chemistry, 17 (1), 25-29. | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | Topoisomerase poisons | es |
dc.subject | SRB assay | es |
dc.subject | Flavonols | es |
dc.subject | Isoflavones | es |
dc.subject | Myricetin | es |
dc.title | Flavonoids As DNA Topoisomerase I Poisons | es |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Farmacología | es |
dc.relation.projectID | SAF 2000-0167 | es |
dc.relation.publisherversion | https://doi.org/10.1080/14756360290011744 | es |
dc.identifier.doi | 10.1080/14756360290011744 | es |
dc.journaltitle | Journal of Enzyme Inhibition and Medicinal Chemistry | es |
dc.publication.volumen | 17 | es |
dc.publication.issue | 1 | es |
dc.publication.initialPage | 25 | es |
dc.publication.endPage | 29 | es |
dc.identifier.sisius | 6609355 | es |
dc.contributor.funder | Ministerio de Ciencia y Tecnología (MCYT). España | es |