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dc.creatorYáñez Vilches, Auroraes
dc.creatorRomero, Antonia M.es
dc.creatorBarrientos Moreno, Martaes
dc.creatorCruz, Estheres
dc.creatorGonzález Prieto, Románes
dc.creatorSharma, Sushmaes
dc.creatorVertegaal, Alfred C.O.es
dc.creatorPrado, Félixes
dc.date.accessioned2024-06-18T14:10:33Z
dc.date.available2024-06-18T14:10:33Z
dc.date.issued2024-05-22
dc.identifier.citationYáñez Vilches, A., Romero, A.M., Barrientos Moreno, M., Cruz, E., González Prieto, R., Sharma, S.,...,Prado, F. (2024). Physical interactions between specifically regulated subpopulations of the MCM and RNR complexes prevent genetic instability. PLoS Genetics, 20 (5), e1011148. https://doi.org/10.1371/journal.pgen.1011148.
dc.identifier.issn1553-7390es
dc.identifier.issn1553-7404es
dc.identifier.urihttps://hdl.handle.net/11441/160648
dc.description.abstractThe helicase MCM and the ribonucleotide reductase RNR are the complexes that provide the substrates (ssDNA templates and dNTPs, respectively) for DNA replication. Here, we demonstrate that MCM interacts physically with RNR and some of its regulators, including the kinase Dun1. These physical interactions encompass small subpopulations of MCM and RNR, are independent of the major subcellular locations of these two complexes, augment in response to DNA damage and, in the case of the Rnr2 and Rnr4 subunits of RNR, depend on Dun1. Partial disruption of the MCM/RNR interactions impairs the release of Rad52 -but not RPA-from the DNA repair centers despite the lesions are repaired, a phenotype that is associated with hypermutagenesis but not with alterations in the levels of dNTPs. These results suggest that a specifically regulated pool of MCM and RNR complexes plays noncanonical roles in genetic stability preventing persistent Rad52 centers and hypermutagenesis.es
dc.formatapplication/pdfes
dc.format.extent27 p.es
dc.language.isoenges
dc.publisherPublic Library of Sciencees
dc.relation.ispartofPLoS Genetics, 20 (5), e1011148.
dc.rightsAtribución 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.titlePhysical interactions between specifically regulated subpopulations of the MCM and RNR complexes prevent genetic instabilityes
dc.typeinfo:eu-repo/semantics/articlees
dc.type.versioninfo:eu-repo/semantics/publishedVersiones
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses
dc.contributor.affiliationUniversidad de Sevilla. Departamento de Biología Celulares
dc.relation.publisherversionhttps://doi.org/10.1371/journal.pgen.1011148es
dc.identifier.doi10.1371/journal.pgen.1011148es
dc.journaltitlePLoS Geneticses
dc.publication.volumen20es
dc.publication.issue5es
dc.publication.initialPagee1011148es

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