Article
Heteroleptic (S^C)-cyclometallated gold(III) complexes as novel antiviral agents
Author/s | Balsera-Manzanero, María
Soengas, Raquel G. Carretero-Ledesma, Marta Ratia, Carlos Iglesias, M. José Pachón Díaz, Jerónimo López-Ortiz, Fernando Cordero Matia, María Elisa Soto, Sara M. Sanchez Cespedes, Javier |
Department | Universidad de Sevilla. Departamento de Medicina Instituto de Biomedicina de Sevilla (IBIS) |
Publication Date | 2024-03 |
Deposit Date | 2024-04-02 |
Published in |
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Abstract | Despite the increasingly widespread clinical impact of adenovirus (HAdV) infections in healthy
individuals and the associated high morbidity in immunosuppressed patients, particularly among
the paediatric population, a ... Despite the increasingly widespread clinical impact of adenovirus (HAdV) infections in healthy individuals and the associated high morbidity in immunosuppressed patients, particularly among the paediatric population, a specific treatment for this virus has yet to be developed. In this study, we report the anti-HAdV activity of sub-micromolar concentrations of four heteroleptic (C^S)- cycloaurated complexes bearing a single thiophosphinamide [Au(dpta)Cl2, Au(dpta)(mrdtc), and Au(dpta)(dedtc)] or thiophosphonamide [Au(bpta)(dedtc)] chelating ligand and a dithiocarbamate moiety. In addition to their low cytotoxicity, the findings of mechanistic assays revealed that these molecules have antiviral activity by targeting stages of the viral replication cycle subsequent to DNA replication. Additionally, all four compounds showed a significant inhibition of human cytomegalovirus (HCMV) DNA replication, thereby providing evidence for potential broad-spectrum antiviral activity. |
Funding agencies | Instituto de Salud Carlos III Ministerio de Ciencia e Innovación |
Project ID. | PI18/01191
PI19/00478 |
Citation | Balsera-Manzanero, M., Soengas, R.G., Carretero-Ledesma, M., Ratia, C., Iglesias, M.J., Pachón Díaz, J.,...,Sanchez Cespedes, J. (2024). Heteroleptic (S^C)-cyclometallated gold(III) complexes as novel antiviral agents. Heliyon, 10 (6), e27601. https://doi.org/10.1016/j.heliyon.2024.e27601. |
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