dc.creator | Balsera-Manzanero, María | es |
dc.creator | Soengas, Raquel G. | es |
dc.creator | Carretero-Ledesma, Marta | es |
dc.creator | Ratia, Carlos | es |
dc.creator | Iglesias, M. José | es |
dc.creator | Pachón Díaz, Jerónimo | es |
dc.creator | López-Ortiz, Fernando | es |
dc.creator | Cordero Matia, María Elisa | es |
dc.creator | Soto, Sara M. | es |
dc.creator | Sanchez Cespedes, Javier | es |
dc.date.accessioned | 2024-04-02T13:07:31Z | |
dc.date.available | 2024-04-02T13:07:31Z | |
dc.date.issued | 2024-03 | |
dc.identifier.citation | Balsera-Manzanero, M., Soengas, R.G., Carretero-Ledesma, M., Ratia, C., Iglesias, M.J., Pachón Díaz, J.,...,Sanchez Cespedes, J. (2024). Heteroleptic (S^C)-cyclometallated gold(III) complexes as novel antiviral agents. Heliyon, 10 (6), e27601. https://doi.org/10.1016/j.heliyon.2024.e27601. | |
dc.identifier.issn | 2405-8440 | es |
dc.identifier.uri | https://hdl.handle.net/11441/156611 | |
dc.description.abstract | Despite the increasingly widespread clinical impact of adenovirus (HAdV) infections in healthy
individuals and the associated high morbidity in immunosuppressed patients, particularly among
the paediatric population, a specific treatment for this virus has yet to be developed. In this study,
we report the anti-HAdV activity of sub-micromolar concentrations of four heteroleptic (C^S)-
cycloaurated complexes bearing a single thiophosphinamide [Au(dpta)Cl2, Au(dpta)(mrdtc),
and Au(dpta)(dedtc)] or thiophosphonamide [Au(bpta)(dedtc)] chelating ligand and a dithiocarbamate moiety. In addition to their low cytotoxicity, the findings of mechanistic assays
revealed that these molecules have antiviral activity by targeting stages of the viral replication
cycle subsequent to DNA replication. Additionally, all four compounds showed a significant inhibition of human cytomegalovirus (HCMV) DNA replication, thereby providing evidence for
potential broad-spectrum antiviral activity. | es |
dc.format | application/pdf | es |
dc.format.extent | 10 p. | es |
dc.language.iso | eng | es |
dc.publisher | Elsevier | es |
dc.relation.ispartof | Heliyon, 10 (6), e27601. | |
dc.rights | Atribución-NoComercial 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc/4.0/ | * |
dc.subject | Adenovirus | es |
dc.subject | Cycloaurated complexes | es |
dc.subject | Antivirals | es |
dc.subject | Metallodrugs | es |
dc.title | Heteroleptic (S^C)-cyclometallated gold(III) complexes as novel antiviral agents | es |
dc.type | info:eu-repo/semantics/article | es |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Medicina | es |
dc.contributor.affiliation | Instituto de Biomedicina de Sevilla (IBIS) | es |
dc.relation.projectID | PI18/01191 | es |
dc.relation.projectID | PI19/00478 | es |
dc.relation.publisherversion | https://www.sciencedirect.com/science/article/pii/S2405844024036326?via%3Dihub | es |
dc.identifier.doi | 10.1016/j.heliyon.2024.e27601 | es |
dc.journaltitle | Heliyon | es |
dc.publication.volumen | 10 | es |
dc.publication.issue | 6 | es |
dc.publication.initialPage | e27601 | es |
dc.contributor.funder | Instituto de Salud Carlos III | es |
dc.contributor.funder | Ministerio de Ciencia e Innovación | es |