Artículos (Instituto de Biomedicina de Sevilla (IBIS))
Recent Submissions
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Propuesta de nueva denominación: esteatosis hepática metabólica (EHmet)
(Arán Ediciones, S.L., 2021)El nombre de una enfermedad no sigue ningún protocolo definido y es habitual la aceptación por parte de la comunidad ...
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Selective expression of the neurexin substrate for presenilin in the adult forebrain causes deficits in associative memory and presynaptic plasticity
(Elsevier, 2021-10-15)Presenilins (PS) form the active subunit of the gamma-secretase complex, which mediates the proteolytic clearance of a ...
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Lupinus angustifolius Protein Hydrolysates Reduce Abdominal Adiposity and Ameliorate Metabolic Associated Fatty Liver Disease (MAFLD) in Western Diet Fed-ApoE−/− Mice
(MDPI, 2021-07-29)Metabolic-associated fatty liver disease (MAFLD) is the most important cause of liver disease worldwide. It is characterized ...
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SARAF and EFHB Modulate Store-Operated Ca2+ Entry and Are Required for Cell Proliferation, Migration and Viability in Breast Cancer Cells
(MDPI, 2021)Breast cancer is among the most common malignancies in women. From the molecular point of view, breast cancer can be ...
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Present and Future of Parkinson’s Disease in Spain: PARKINSON-2030 Delphi Project
(MDPI, 2021-07-31)Abstract: Parkinson’s disease (PD) is a chronic progressive and irreversible disease and the second most common ...
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Esclerosis múltiple y trastornos asociados al consumo de alcohol: mortalidad atribuible, prolongación de estancias y exceso de costes hospitalarios
(Sociedad Española de Neurología, 2016-10-22)Introducción: El objetivo de este estudio es el análisis del impacto de los trastornos asociados al consumo de alcohol(TCA) ...
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Prolyl Hydroxylase-dependent Modulation of Eukaryotic Elongation Factor 2 Activity and Protein Translation under Acute Hypoxia
(American Society for Biochemistry and Molecular Biology, 2012-02-03)Early adaptive responses to hypoxia are essential for cell survival, but their nature and underlying mechanisms are poorly ...
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Immunomodulatory and Antioxidant Properties of Wheat Gluten Protein Hydrolysates in Human Peripheral Blood Mononuclear Cells
(MDPI, 2020-06-04)Peptides from several plant food proteins not only maintain the nutritional values of the original protein and decrease ...
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Peripheral CD39-expressing T regulatory cells are increased and associated with relapsing-remitting multiple sclerosis in relapsing patients
(Nature Research, 2019-02-19)CD39, an ectonucleotidase that hydrolyses pro-infammatory ATP, is a marker of highly active and suppressive T regulatory ...
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Glucose sensing by carotid body glomus cells: potential implications in disease
(Frontiers Media, 2014-10-15)The carotid body (CB) is a key chemoreceptor organ in which glomus cells sense changes in blood O2, CO2, and pH levels. ...
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A variant in the MICA gene is associated with liver fbrosis progression in chronic hepatitis C through TGF-β1 dependent mechanisms
(Nature Research, 2019-02-05)Hepatocarcinogenesis is tightly linked to liver fibrosis. Recently, two GWAS variants, MICA rs2596542 and DEPDC5 rs1012068 ...
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Phosphorylated-insulin growth factor I receptor (p-IGF1R) and metalloproteinase-3 (MMP3) expression in advanced gastrointestinal stromal tumors (GIST). A GEIS 19 study
(BMC, 2016-06-29)Background: Most GISTs have mutations in KIT or PDGFRA. Patients with advanced GIST with KIT exon 9, PDGFRA mutation or ...
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Resistance of subventricular neural stem cells to chronic hypoxemia despite structural disorganization of the germinal center and impairment of neuronal and oligodendrocyte survival
(Dove Medical Press Ltd., 2015)Chronic hypoxemia, as evidenced in de-acclimatized high-altitude residents or in patients with chronic obstructive ...
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Neurocognitive Function in Acromegaly after Surgical Resection of GH-Secreting Adenoma versus Naïve Acromegaly
(Elsevier, 2013-04-04)Patients with active untreated acromegaly show mild to moderate neurocognitive disorders that are associated to chronic ...
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Integrated molecular signaling involving mitochondrial dysfunction and alteration of cell metabolism induced by tyrosine kinase inhibitors in cancer
(Elsevier, 2020-03-16)Cancer cells have unlimited replicative potential, insensitivity to growth-inhibitory signals, evasion of apoptosis,cellular ...
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Changing Trends in the Epidemiology and Risk Factors of Pneumocystis Pneumonia in Spain
(2019-10-04)Objective: The information about the epidemiology of Pneumocystis pneumonia (PcP) in Europe is scarce, and in Spain there ...
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Trends in the prevalence and distribution of HTLV-1 and HTLV-2 infections in Spain
(BMC, 2012)Background Although most HTLV infections in Spain have been found in native intravenous drug users carrying HTLV-2, the ...
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Parasites and malignancies, a review, with emphasis on digestive cancer induced by Cryptosporidium parvum (Alveolata: Apicomplexa)
(EDP Open, 2012-05-15)The International Agency for Research on Cancer (IARC) identifies ten infectious agents (viruses, bacteria, parasites) ...
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No difference in effectiveness of treatment simplification to boosted or unboosted atazanavir plus lamivudine in virologically suppressed in HIV-1-infected patients
(Public Library of Science, 2018-09-20)Background Simplification strategies of antiretroviral treatment represent effective tools for the reduction of drug-induced ...
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Liver Fibrosis, Host Genetic and Hepatitis C Virus Related Parameters as Predictive Factors of Response to Therapy against Hepatitis C Virus in HIV/HCV Coinfected Patients
(Public Library of Science, 2014-07-11)Objective: To establish the role of liver fibrosis as a predictive tool of response to pegylated interferon alpha (Peg-IFN) ...