Author profile: Pachón Díaz, Jerónimo
Institutional data
| Name | Pachón Díaz, Jerónimo |
| Department | Medicina |
| Knowledge area | Medicina |
| Professional category | Investigador Honorario |
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No. publications
80
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| Publications |
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Article
 Carbapenem Combinations for Infections Caused by Carbapenemase-Producing Pseudomonas aeruginosa: Experimental In Vitro and In Vivo Analysis
(MDPI, 2022-09-07)
In the context of difficult-to-treat carbapenem-resistant Pseudomonas aeruginosa infections, we evaluated imipenem, ... |
PhD Thesis
Neumonía adquirida en la comunidad de etiología viral: diversidad, especificidad diagnóstica y factores pronósticos
(2022-06-27)
La PCR en tiempo real para virus respiratorios ha ampliado el diagnóstico etiológico de la neumonía adquirida en la comunidad ... |
Article
Impact of early interferon-β treatment on the prognosis of patients with COVID-19 in the first wave: A post hoc analysis from a multicenter cohort
(Elsevier France - Editions scientifiques medicales Elsevier, 2022-01-01)
Background: Interferon-β is an attractive drug for repurposing and use in the treatment of COVID-19, based on its in vitro ... |
Article
Excretion and viability of SARS‑CoV‑2 in feces and its association with the clinical outcome of COVID‑19
(Nature Publishing Group, 2022-01-01)
The main objective was to evaluate the viability of the SARS-CoV-2 viral particles excreted in stools. In addition, we ... |
Article
Repurposing of the Tamoxifen Metabolites to Treat Methicillin-Resistant Staphylococcus epidermidis and Vancomycin-Resistant Enterococcus faecalis Infections
(American Society of Microbiology, 2021-10-20)
Repurposing drugs provides a new approach to the fight against multidrug-resistant (MDR) bacteria. We have reported that ... |
Article
Potential tamoxifen repurposing to combat infections by multidrug-resistant Gram-negative bacilli
(2021-05-26)
The development of new strategic therapies for multidrug-resistant bacteria, like the use of non-antimicrobial approaches ... |
Article
Repurposing of the tamoxifen metabolites to combat infections by multidrug-resistant gram-negative bacilli
(Multidisciplinary Digital Publishing Institute, 2021-03-22)
The development of new strategic antimicrobial therapeutic approaches, such as drug repurposing, has become an urgent need. ... |
Article
Impact of treating asymptomatic bacteriuria in kidney transplant recipients: a prospective cohort study
(MDPI, 2021-02-22)
This study aims to define the epidemiologic, clinical, and microbiological features of asymptomatic bacteriuria (AB) and ... |
Article
Efficacy of lysophosphatidylcholine as direct treatment in combination with colistin against acinetobacter baumannii in murine severe infections models
(MDPI, 2021-02-17)
The stimulation of the immune response to prevent the progression of an infection may be an adjuvant to antimicrobial ... |
Article
Discovery of a small molecule inhibitor of human adenovirus capable of preventing escape from the endosome
(MDPI, 2021-02-05)
Human adenoviruses (HAdVs) display a wide range of tissue tropism and can cause an array of symptoms from mild respiratory ... |
Article
SARS-CoV-2 viral load in nasopharyngeal swabs is not an independent predictor of unfavorable outcome
(NATURE PUBLISHING GROUP, 2021-01-01)
The aim was to assess the ability of nasopharyngeal SARS-CoV-2 viral load at frst patient’s hospital evaluation to predict ... |
Article
Efficacy of Fosfomycin and Its Combination With Aminoglycosides in an Experimental Sepsis Model by Carbapenemase-Producing Klebsiella pneumoniae Clinical Strains
(Frontiers Media, 2021-01-01)
Carbapenemase-producing Klebsiella pneumoniae infections are an increasing global threat with scarce and uncertain treatment ... |
Article
Development and validation of a prediction model for 30-day mortality in hospitalised patients with COVID-19: the COVID-19 SEIMC score
(BMJ PUBLISHING GROUP, 2021-01-01)
Objective: To develop and validate a prediction model of mortality in patients with COVID-19 attending hospital emergency ... |
Article
Risk factors for unfavorable outcome and impact of early post-transplant infection in solid organ recipients with COVID-19: a prospective multicenter cohort study
(Public Library Science, 2021-01-01)
The aim was to analyze the characteristics and predictors of unfavorable outcomes in solid organ transplant recipients ... |
Article
Treatment with tocilizumab or corticosteroids for COVID-19 patients with hyperinflammatory state: a multicentre cohort study (SAM-COVID-19)
(Science Direct, 2021-01-01)
Objectives The objective of this study was to estimate the association between tocilizumab or corticosteroids and the risk ... |
Article
AOA-2 Derivatives as Outer Membrane Protein A Inhibitors for Treatment of Gram-Negative Bacilli Infections
(Frontiers Media S.A., 2021-01-01)
Previously, we identified that a cyclic hexapeptide AOA-2 inhibited the interaction of Gram-negative bacilli (GNB) like ... |
Article
Efficacy of dual carbapenem treatment in a murine sepsis model of infection due to carbapenemase-producing Acinetobacter baumannii
(Oxford University Press, 2021-01-01)
Objectives: To evaluate the in vivo efficacy of a dual carbapenem combination containing imipenem plus mero penem against ... |
Article
T-cells immune response controls the high incidence of adenovirus infection in adult allogenic hematopoietic transplantation recipients
(FERRATA STORTI FOUNDATION, 2021-01-01)
Human adenovirus (HAdV) can produce disseminated disease with high mortality in pediatric allogenic hematopoietic stem ... |
Article
Identification and validation of clinical phenotypes with prognostic implications in patients admitted to hospital with COVID-19: a multicentre cohort study
(Elsevier, 2021-01-01)
Background The clinical presentation of COVID-19 in patients admitted to hospital is heterogeneous. We aimed to determine ... |
Article
In vitro activity of pentamidine alone and in combination with antibiotics against multidrug-resistant clinical Pseudomonas aeruginosa strains
(MDPI, 2020-12-09)
Multidrug-resistant (MDR) Pseudomonas aeruginosa is a public health problem causing both community and hospital-acquired ... |
PhD Thesis
Reposicionamiento de fármacos para el tratamiento de infecciones causadas por bacilos gramnegativos multirresistentes
(2020-07-14)
El aumento de bacterias multirresistentes y la dificultad de encontrar un tratamiento eficaz para este tipo de infecciones, ... |
PhD Thesis
Integration of omics and bioinformatics to identify new therapeutic targets for Acinetobacter baumannii. Virulence role of CarO in Acinetobacter baumannii infections
(2020-07-06)
Acinetobacter baumannii remains a significant and difficult-to-treat pathogen that causes a range of interactions with the ... |
PhD Thesis
Indicaciones de la tomografía computerizada de tórax en el estudio de extensión del cáncer epidermoide de cabeza y cuello
(2020-06-17)
Antecedentes. Actualmente, la incidencia de metástasis pulmonares y nódulos pulmonares inespecíficos publicadas en el ... |
PhD Thesis
Bacteriemias por Escherichia coli: análisis clínico-epidemiológico, de factores de patogenicidad y mecanismos de resistencia a betalactámicos/inhibidores de betalactamasas
(2020-02-03)
Las infecciones por bacterias multirresistentes son un serio problema a nivel mundial. La aparición constante de mecanismos ... |
PhD Thesis
Respuesta inmunitaria celular y eficacia del tratamiento con células de memoria e IgM en la neumonía experimental por Pseudomonas aeruginosa y Acinetobacter baumannii
(2020-01-16)
Acinetobacter baumannii y Pseudomonas aeruginosa son bacilos Gram-negativos (BGN) no fermentadores, y paradigmas de las ... |
PhD Thesis
Uso de fármacos, con mecanismo de acción sobre la pared bacteriana, como adyuvante al tratamiento antimicrobiano para las infecciones causadas por bacilos Gram-negativos multirresistentes
(2019-12-11)
El aumento de las tasas de resistencia antimicrobiana ha dibujado un escenario global donde la dificultad de encontrar un ... |
PhD Thesis
Estudio de la incidencia de la infección por adenovirus, su cinética de replicación, y la respuesta inmune celular: impacto en la progresión clínica de pacientes adultos receptores de TPH
(2019-12-10)
El adenovirus humano (HAdV) destaca como el virus que mayor incremento ha experimentado en cuanto a su incidencia en ... |
Article
Prevalence and clinical impact of Streptococcus pneumoniae nasopharyngeal carriage in solid organ transplant recipients
(2019-08-06)
Background: S. pneumoniae is the leading cause of community-acquired pneumonia in the solid organ transplant recipient ... |
| PhD Thesis |
Article
Repositioning salicylanilide anthelmintic drugs to treat adenovirus infections
(Nature Research, 2019-01-09)
The repositioning of drugs already approved by regulatory agencies for other indications is an emerging alternative for ... |
Article
Phylogeny, Resistome, and Virulome of Escherichia coli Causing Biliary Tract Infections
(MDPI, 2019-01-01)
Escherichia coli is the most frequent Gram-negative bacilli involved in intra-abdominal infections. However, despite high ... |
Article
Relationship Between the Quorum Network (Sensing/Quenching) and Clinical Features of Pneumonia and Bacteraemia Caused by A. baumannii
(Frontiers Research Foundation, 2018-12-17)
Acinetobacter baumannii (Ab) is one of the most important pathogens associated with nosocomial infections, especially ... |
Article
Synergistic Activity of Niclosamide in Combination With Colistin Against Colistin-Susceptible and Colistin-Resistant Acinetobacter baumannii and Klebsiella pneumoniae
(Frontiers Research Foundation, 2018-10-03)
Colistin is among the few antibiotics effective against multidrug-resistant Acinetobacter baumannii and Klebsiella pneumoniae ... |
Article
Intracellular Trafficking and Persistence of Acinetobacter baumannii Requires Transcription Factor EB
(American Society for Microbiology, 2018-03-28)
Acinetobacter baumannii is a significant human pathogen associated with hospital-acquired infections. While adhesion, an ... |
PhD Thesis
 Hypoxia effect on genetic regulation and virulence in Acinetobacter baumannii and Pseudomonas aeruginosa, in vitro and in vivo, and on innate immune response in infections caused by both pathogens.
(2018-01-01)
The emergence of multi-drug resistant Gram-negative bacilli infections is a well-recognized global health challenge in ... |
Article
Protective Effects of Human and Mouse Soluble Scavenger-Like CD6 Lymphocyte Receptor in a Lethal Model of Polymicrobial Sepsis
(American Society for Microbiology, 2017-11-01)
Sepsis still constitutes an unmet clinical need, which could benefit from novel adjunctive strategies to conventional ... |
| PhD Thesis |
PhD Thesis
Non-antimicrobial strategies for the prevention and treatment of infections by multidrug-resistant gram-negative bacilli
(2017-05-19)
Due to the increased of antimicrobial resistance rates and the difficulty of having effective treatment for infections ... |
Article
Pathogenic Acinetobacter species have a functional type I secretion system and contact-dependent inhibition systems
(American Society for Biochemistry and Molecular Biology, Inc., 2017-04-03)
Pathogenic Acinetobacter species, including Acinetobacter baumannii and Acinetobacter nosocomialis, are opportunistic human ... |
Article
Combating virulence of Gramnegative bacilli by OmpA inhibition
(Nature Research, 2017-01-01)
Preventing the adhesion of pathogens to host cells provides an innovative approach to tackling multidrug-resistant bacteria. ... |
PhD Thesis
Nuevas alternativas terapéuticas para el tratamiento de infecciones por adenovirus: síntesis y evaluación de pequeñas moléculas antivirales
(2016-12-16)
El adenovirus humano (HAdV) es un patógeno oportunista común raramente relacionado con sintomatología grave en individuos ... |
PhD Thesis
Influencia de la resistencia a imipenen y de diferentes mecanismos de virulencia en acinetobacter baumannii en la colonización o infección de vías respiratorias y la mortalidad en pacientes con ventilación mecánica en cuidados intensivos
(2016-03-14)
Acinetobacter baumannii es un bacilo gramnegativo no fermentador con gran importancia clínica por su capacidad para colonizar ... |
PhD Thesis
Cambios en el espectro etiológico de la fiebre de duración intermedia en el sur de Europa
(2016-02-02)
La Fiebre de Duración Intermedia (FDI) es un motivo de consulta frecuente en Andalucía, de pronóstico generalmente favorable ... |
Article
Phosphorylation of gH2AX as a novel prognostic biomarker for laryngoesophageal dysfunction-free survival
(Impact Journals, 2016-01-04)
Current larynx preservation treatments have achieved an improvement of laryngoesophageal dysfunction-free survival (LDS) ... |
Article
Colistin Dosage without Loading Dose Is Efficacious when Treating Carbapenem- Resistant Acinetobacter baumannii Ventilator- Associated Pneumonia Caused by Strains with High Susceptibility to Colistin
(Public Library Of Science., 2016-01-01)
Objectives This study aims to analyze the mortality and the length of ICU stay (LOS) of A. baumannii VAP compared to ... |
Article
Genomic Evolution of Two Acinetobacter baumannii Clinical Strains from ST-2 Clones Isolated in 2000 and 2010 (ST-2_clon_2000 and ST-2_clon_2010)
(2016-01-01)
Acinetobacter baumannii is a successful nosocomial pathogen due to its ability to persist in hospital environments by ... |
PhD Thesis
Impacto de la lecitina de unión a la manosa (MBL) y beta-defensina 2 en la susceptibilidad frente a infecciones en neonatos prematuros extremos
(2015-09-14)
Introducción: Los recién nacidos prematuros extremos (< 32 semanas de edad gestacional, EG) son una población de riesgo ... |
Patent
Uso de la lisofosfatidilcolina para la prevención y/o tratamiento de infecciones causadas por Acinetobacter baumannii
(Oficina Española de Patentes y Marcas , 2015-05-26)
Uso de la lisofosfatidilcolina, de sus composiciones y de sus formas farmacéuticas en la elaboración de un medicamento ... |
Article
Evaluación de la actividad anti-adenovirus de diferentes librerías químicas de pequeñas moléculas y caracterización de su mecanismo de acción
(Universidad Pablo de Olavide, 2015-01-01)
Motivación: El adenovirus humano (HAdV) es un virus que causa infecciones autolimitadas y leves en ... |
PhD Thesis
La enfermedad grave por el virus influenza A (H1N1) pdm09. Epidemiología, presentación clínica y factores de riesgo para mortalidad.
(2014-05-01)
El objetivo principal del trabajo de investigación objeto de esta tesis ha sido describir las características de la infección ... |
Article
Immunization with Lipopolysaccharide-Deficient Whole Cells Provides Protective Immunity in an Experimental Mouse Model of Acinetobacter baumannii Infection
(2014-01-01)
The increasing clinical importance of infections caused by multidrug resistant Acinetobacter baumannii warrants the ... |
Article
Contribution of Efflux Pumps, Porins, and B-Lactamases to Multidrug Resistance in Clinical Isolates of Acinetobacter baumannii
(American Society for Microbiology, 2013-11-01)
Weinvestigated the mechanisms of resistance to carbapenems, aminoglycosides, glycylcyclines, tetracyclines, and quinolones ... |
PhD Thesis
Concentraciones plasmáticas de Peginterferón-a 2a y Ribavirina y polimorfismo de la IL-28B en la cinética viral y respuesta al tratamiento de la hepatopatía crónica por virus C en pacientes coinfectados por VIH y VHC genotipos 1-4
(2013-09-26)
Justificación del estudio. Las concentraciones plasmáticas, tanto de interferón pegilado-alfa (PegIFN-alfa) como ribavirina ... |
Article
Inoculum Effect on the Efficacies of Amoxicillin-Clavulanate, Piperacillin-Tazobactam, and Imipenem against Extended-Spectrum -Lactamase (ESBL)-Producing and Non-ESBL-Producing Escherichia coli in an Experimental Murine Sepsis Model
(American Society for Microbiology, 2013-04-01)
Escherichia coli is commonly involved in infections with a heavy bacterial burden. Piperacillin-tazobactam and carbapenems ... |
Article
Platelet-activating Factor Receptor Initiates Contact of Acinetobacter baumannii Expressing Phosphorylcholine with Host Cells
(2012-06-01)
Adhesion is an initial and important step in Acinetobacter baumannii causing infections. However, the exact molecular ... |
Patent
Vacuna frente a acinetobacter baumannii.
(Oficina Española de Patentes y Marcas , 2011-10-25)
Vacuna frente a Acinetobacter baumannii.La presente invención se refiere a una composición que comprende proteínas de la ... |
Article
In vitro effect of qnrA1, qnrB1, and qnrS1 genes on fluoroquinolone activity against isogenic Escherichia coli isolates with mutations in gyrA and parC
(American Society for Microbiology, 2011-03-01)
This article provides an analysis of the in vitro effect of qnrA1, qnrB1, and qnrS1 genes, combined with quinolone-resistant ... |
PhD Thesis
Nuevas alternativas terapéuticas frente a acinetobacter baumannii. Estudios pre-clínicos de péptidos híbridos de cecropina A-melitina, una quinolona de nueva generación (UB-8902) y ácido clavulánico
(2011-01-11)
Acinetobacter baumannii se ha convertido en un paradigma de microorganismo nosocomial emergente, debido a la importancia ... |
Article
Impaired Virulence and In Vivo Fitness of Colistin-Resistant Acinetobacter baumannii
(Oxford University Press, 2011-01-07)
Acinetobacter baumannii (American Type Culture Collection strain 19606) acquires mutations in the pmrB gene during the in ... |
Article
Clinical Features of Infections and Colonization by Acinetobacter Genospecies 3
(American Society for Microbiology, 2010-12-01)
Two hundred twenty-one isolates of Acinetobacter baumannii and 15 of Acinetobacter genospecies 3 (AG3) were consecutively ... |
Article
Infección por virus pandémico (H1N1) 2009 en Andalucía
(2010-01-01)
Desde que en abril de 2009 la Organización Mundial de la Salud (OMS) alertó de la existencia de casos de infección humana ... |
Article
Nosocomial outbreak of infection with pan-drug-resistant Acinetobacter baumannii in a tertiary care university hospital
(Slack, 2009-03-01)
TO describe what is, to our knowledge, the first nosocomial outbreak of infection with pan–drug-resistant (including ... |
Article
Genetic Variability among ampC Genes from Acinetobacter Genomic Species 3
(American Society for Microbiology, 2009-03-01)
As a part of a nationwide study in Spain, 15 clinical isolates of Acinetobacter genomic species 3 (AG3) were analyzed. The ... |
PhD Thesis
Tratamientos de la neumonía experimental por Staphylococcus aureus : estudios de eficacia terapéutica de cotrimoxazol, cloxacilina, linezolid y vancomicina frente a cepas S. aureus sensible y resistente a meticilina
(2009-01-01)
El objetivo general de este proyecto es comparar la actividad de cotrimoxazol, vancomicina, linezolid y cloxacilina ... |
Article
Efficacy of cefepime and imipenem in experimental murine pneumonia caused by porin-deficient Klebsiella pneumoniae producing CMY-2 β-lactamase
(American Society for Microbiology, 2005-08-01)
Previous studies have shown decreased in vitro activity of zwitterionic cephalosporins and carbapenems against porin-deficient ... |
PhD Thesis
Tratamiento de la neumonía experimental por acinetobacter baumannii multirresistente y panresistente. Estudios de sinergía con carbapenemes, sulbactam, rifampicina y colistina in vitro e in vivo
(2005-06-06)
Acinetobacter baumannii es un bacilo gramnegativo aerobio causante de infecciones nosocomiales. El tratamiento de estas ... |
Article
Clinical features and epidemiology of acinetobacter baumanni colonization and infection in spanish hospitals
(SLACK, 2004-10-01)
OBJECTIVE: To investigate the clinical features and the epidemiology of Acinetobacter baumannii in Spanish hospitals. DESIGN: ... |
Article
Antimicrobial Susceptibility and Mechanisms of Resistance to Quinolones and b-Lactams in Acinetobacter Genospecies 3
(American Society for Microbiology, 2004-04-01)
Antimicrobial susceptibility was determined in 15 epidemiologically unrelated clinical isolates of Acinetobacter genospecies ... |
Article
Type 1 Integrons in Epidemiologically Unrelated Acinetobacter baumannii Isolates Collected at Spanish Hospitals
(American Society for Microbiology, 2004-01-01)
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PhD Thesis
Neumonías en pacientes con cáncer: análisis epidemiológico, utilidad de los métodos diagnósticos y pronóstico
(2003-06-18)
En los últimos años se ha producido un cambio en la población de pacientes que presentan neumonía, incluyendo el número ... |
PhD Thesis
Endocarditis neumocócica experimental causada por cepas con diferentes sensibilidades a la penicilina. Comparación de estudios in vitro e in vivo
(2000-07-19)
La frecuente aparición de cepas de neumococos con sensibilidad disminuida a la penicilina hace necesaria la realización ... |
| PhD Thesis |
PhD Thesis
Neumonías bacterianas graves de adquisición comunitaria en pacientes con infección por el virus de la inmunodeficiencia humana. Factores asociados a la mortalidad y desarrollo de un sistema pronóstico
(1999-12-20)
Las neumonías bacterianas constituyen una causa importante de morbilidad y mortalidad en los pacientes con infección por ... |
PhD Thesis
Neumonía experimental por acinetobacter baumannii. Caracterización del modelo y efectividad del tratamiento con diferentes antimicrobianos
(1999-12-20)
JUSTIFICACION Como ya se ha comentado en la introducción existen dos motivos fundamentales, las epidemias hospitalarias y ... |
PhD Thesis
Características de la epidemia por el virus de la inmunodeficiencia humana en Andalucía. Análisis desde la atención hospitalaria mediante encuestas transversales secuenciales, 1992-1995
(1998-12-04)
De todo lo anteriormente expuesto, se deduce que la epidemia VIH/sida: 1. Constituye un importante problema de Salud ... |
PhD Thesis
Infección de la herida quirúrgica en cirugía cardíaca
(1998-06-18)
Estudio de los factores de riesgo para la aparición de infeccións superficial o profundo de la herida de esternotomía, La ... |
PhD Thesis
Endocarditis infecciosa: Análisis de etiología, factores pronósticos y tratamiento, 1984-1992
(1996-05-24)
Resulta evidente que la endocarditis infecciosa es una entidad con una alta tasa de mortalidad, y que en ocasiones puede ... |
| PhD Thesis |
| PhD Thesis |
PhD Thesis
Alteraciones metabólicas en las esclerosis vasculares: estudio de los hidratos de carbono unidos a proteínas en las esclerosis vasculares de la involución y en las hiperlipoproteinemias primarias
(1973-09-01)
Ya hemos visto con anterioridad que en las Esclerosis Vasculares, una de las bases histológicas, de la lesión vascular, ... |