Article
Aging and Oxidative Stress Decrease Pineal Elongation Factor 2: In Vivo Protective Effect of Melatonin in Young Rats Treated With Cumene Hydroperoxide
Author/s | Muñoz Pinto, Mario Faustino
Argüelles Castilla, Sandro Cano Rodríguez, María Mercedes Marotta, Francesco Ayala Gómez, Antonio |
Department | Universidad de Sevilla. Departamento de Bioquímica y Biología Molecular Universidad de Sevilla. Departamento de Fisiología |
Publication Date | 2017 |
Deposit Date | 2024-01-25 |
Published in |
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Abstract | We studied the alterations of Elongation Factor 2 (eEF2) in the pineal gland of aged rats as well as the possible protective role of exogenous melatonin on these changes in young rats treated with cumene hydroperoxide (CH), ... We studied the alterations of Elongation Factor 2 (eEF2) in the pineal gland of aged rats as well as the possible protective role of exogenous melatonin on these changes in young rats treated with cumene hydroperoxide (CH), a compound that promotes lipid peroxidation and inhibits protein synthesis. The study was performed using male Wistar rats of 3 (control), 12, and 24 months and 3-month-old rats treated with CH, melatonin, and CH plus melatonin. We found that pineal eEF-2 is affected by aging and CH, these changes being prevented by exogenous melatonin in the case of CH-treated rats. The proteomic studies show that many other proteins are affected by aging and oxidative stress in the pineal gland. The results suggest that one of the possible mechanisms underlying pineal gland dysfunction during aging is the effect of lipid peroxidation on eEF-2, which is a key component of protein synthesis machinery. |
Funding agencies | Junta de Andalucía |
Project ID. | P10-CTS-6494 |
Citation | Muñoz Pinto, M.F., Argüelles Castilla, S., Cano Rodríguez, M.M., Marotta, F. y Ayala Gómez, A. (2017). Aging and Oxidative Stress Decrease Pineal Elongation Factor 2: In Vivo Protective Effect of Melatonin in Young Rats Treated With Cumene Hydroperoxide. Journal of Cellular Biochemistry, 118 (1), 182-190. https://doi.org/10.1002/jcb.25624. |
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